Characterization and in vitro anticancer properties of chitosan-microencapsulated flavan-3-ols-rich grape seed extracts

Iannone, Michelangelo; Mare, Rosario; Paolino, Donatella; Gagliardi, Agnese; Froiio, Francesca; Cosco, Donato; Fresta, Massimo

doi:10.1016/j.ijbiomac.2017.07.022

Cited by 35 publications

(22 citation statements)

References 25 publications

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“…Seeds of the exotic fruit 'red pitaya' (Hylocereus polyrhizus (F.A.C.Weber) Britton & Rose) is reported to have high amounts of phenolic compound with catechin being the major flavonoid and ascorbic acid content exhibiting good antioxidant activities [143]. Further, grape seed which is one of the much studied raw material is reported to contain bioactive components such as phenols, tannin, resveratrol, quercetin, flavonoids and anthocyanins, exhibiting antimicrobial, antioxidant and anticancer properties along with providing cardiovascular protective effects [144][145][146][147]. Date (Phoenix dactylifera L.) seeds wastes are also valued for their bioactive contents such as that polyphenolic compounds, flavonoids, flavonols, anthocyanins, proanthocyanidins and ascorbic acid [148].…”

Section: Bioactive Compounds From Seedsmentioning

confidence: 99%

Bioactives from Agri-Food Wastes: Present Insights and Future Challenges

2020

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Sustainable utilization of agri-food wastes and by-products for producing value-added products (for cosmetic, pharmaceutical or food industrial applications) provides an opportunity for earning additional income for the dependent industrial sector. Besides, effective valorisation of wastes/by-products can efficiently help in reducing environmental stress by decreasing unwarranted pollution. The major focus of this review is to provide comprehensive information on valorisation of agri-food wastes and by-products with focus laid on bioactive compounds and bioactivity. The review covers the bioactives identified from wastes and by-products of plants (fruits, exotic fruits, vegetables and seeds), animals (dairy and meat) and marine (fish, shellfish seaweeds) resources. Further, insights on the present status and future challenges of sustainably utilizing agri-food wastes/by-products for value addition will be highlighted.

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Section: Bioactive Compounds From Seedsmentioning

confidence: 99%

Bioactives from Agri-Food Wastes: Present Insights and Future Challenges

2020

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“…Several studies have focused their attention on the modulation of the bioadhesive properties of poloxamer 407-gels by means of chitosan, a natural polysaccharide derived from the chitin of the exoskeletons of shrimp and crabs, which is widely used in pharmaceutical application [ 59 , 115 , 116 ]. The addition of chitosan improved the mucoadhesive characteristics and the gel strength of poloxamer-gels, due to the positively-charged amine residues of the compound, which promote a great deal of interaction with the negatively-charged mucous [ 101 ].…”

Section: Poloxamer 407-based Mucoadhesive Formulationsmentioning

confidence: 99%

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

et al. 2018

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Poloxamer 407, also known by the trademark Pluronic® F127, is a water-soluble, non-ionic triblock copolymer that is made up of a hydrophobic residue of polyoxypropylene (POP) between the two hydrophilic units of polyoxyethylene (POE). Poloxamer 407-based hydrogels exhibit an interesting reversible thermal characteristic. That is, they are liquid at room temperature, but they assume a gel form when administered at body temperature, which makes them attractive candidates as pharmaceutical drug carriers. These systems have been widely investigated in the development of mucoadhesive formulations because they do not irritate the mucosal membranes. Based on these mucoadhesive properties, a simple administration into a specific compartment should maintain the required drug concentration in situ for a prolonged period of time, decreasing the necessary dosages and side effects. Their main limitations are their modest mechanical strength and, notwithstanding their bioadhesive properties, their tendency to succumb to rapid elimination in physiological media. Various technological approaches have been investigated in the attempt to modulate these properties. This review focuses on the application of poloxamer 407-based hydrogels for mucosal drug delivery with particular attention being paid to the latest published works.

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“…It is reported that these wastes contain a variety of phytochemicals, especially phenols and flavonoids like anthocyanins, resveratrol, tannin and quercetin [ 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. These bioactive components possess various outstanding bioactivities, such as antibacterial, anticancer, antioxidant, anti-inflammation and hepatic and cardiovascular protection effects [ 9 , 10 , 11 , 12 , 13 ], and have great safety and effectiveness advantages in preventing chronic diseases [ 14 , 15 , 16 , 17 ]. They can be used as raw materials to produce functional foods, food additives and pharmaceuticals [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of Grape Wastes as a Natural Source of Bioactive Compounds

et al. 2018

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Grapes are widely used in the wine and juice industries, which can lead to massive amounts of waste, mostly grape peels and seeds. The antioxidant capacities, total phenolic and flavonoid contents and phenolic profiles of peels and seeds from 30 grape varieties were systemically assessed. The antioxidant activities of fat-soluble, water-soluble and insoluble-bound fractions of grape peels and seeds were evaluated using ferric-reducing antioxidant power and Trolox equivalent antioxidant capacity assays, and their total phenolic contents and total flavonoid contents were determined by the Folin-Ciocalteu method and AlCl3 colorimetry, respectively. It was found that the antioxidant capacities were diverse among different grape peels and seeds. Moreover, several phenolic compounds were identified and quantified, including gallic acid, cyanidin-3-glucoside, epicatechin, catechin gallate, ferulaic acid, rutin and resveratrol, which could contribute to the antioxidant capacities of these grape peels and seeds. Several grape wastes with strong antioxidant activity could be abundant sources of natural bioactive compounds, and have the potential for development into functional foods, food additives and pharmaceuticals.

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Characterization and in vitro anticancer properties of chitosan-microencapsulated flavan-3-ols-rich grape seed extracts

Cited by 35 publications

References 25 publications

Bioactives from Agri-Food Wastes: Present Insights and Future Challenges

Bioactives from Agri-Food Wastes: Present Insights and Future Challenges

Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview

Potential of Grape Wastes as a Natural Source of Bioactive Compounds

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