Characterization and immunomodulatory activity of polysaccharides derived from Dendrobium tosaense

Yang, Li-Chan; Lu, Ting‐Jang; Hsieh, Chang-Chi; Lin, Wen‐Chuan

doi:10.1016/j.carbpol.2014.05.007

Cited by 53 publications

(28 citation statements)

References 27 publications

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“…In addition, the water-soluble polysaccharides (DTP) derived from D. tosaense were isolated by using HPAEC-PAD, HP-SEC, GC–MS, and NMR spectroscopy. They significantly increased the number of natural killer (NK) cells, NK cytotoxicity, macrophage phagocytosis, and cytokine induction in splenocytes, when administered orally to BALB/c mice for 3 weeks [ 59 ].…”

Section: The Pharmacological Effects Of Dendrobium mentioning

confidence: 99%

Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology inDendrobiumPlants

Lam

Yao

et al. 2015

Evidence-Based Complementary and Alternative Medicine

119

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Dendrobium species, commonly known as “Shihu” or “Huangcao,” represents the second largest genus of Orchidaceae, which are used commonly as tonic herbs and healthy food in many Asian countries. The aim of this paper is to review the history, chemistry, and pharmacology of different Dendrobium species on the basis of the latest academic literatures found in Google Scholar, PubMed, Sciencedirect, Scopus, and SID.

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Section: The Pharmacological Effects Of Dendrobium mentioning

confidence: 99%

Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology inDendrobiumPlants

Lam

Yao

et al. 2015

Evidence-Based Complementary and Alternative Medicine

119

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“…In recent years, soluble polysaccharides were isolated and extracted from the stems of various Dendrobium species 5, 6 . In D. officinale , most water-soluble polysaccharides, comprising glucose, mannose, arabinose and xylose, are contained in the stems 7 .…”

Section: Introductionmentioning

confidence: 99%

Identification and analysis of genes associated with the synthesis of bioactive constituents in Dendrobium officinale using RNA-Seq

Shen

Guo

Chen

et al. 2017

Sci Rep

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Dendrobium officinale L. is an important traditional herb with high commercial value in China. Several bioactive constituents, including polysaccharides and alkaloids, reportedly make major contributions toward the excellent medicinal effect of D. officinale. In this study, the contents of polysaccharides and alkaloids in various organs of D. officinale were measured and compared. We took advantage of transcriptomes from four organs to explore biological mechanisms in the organ-specific distribution of active ingredients in D. officinale. Based on Kyoto Encyclopedia of Genes and Genomes pathways, unigenes related to the enzymes involved in fructose and mannose metabolism and unigenes associated with putative upstream elements of the alkaloid biosynthetic pathway were identified. A large number of candidates, including 35 full-length glycosyltransferase genes and 49 full-length P450 genes, were also identified based on the transcriptome data, and the organ-specific expression pattern of these genes was determined. Furthermore, differential expression of all candidate genes was analyzed in two Dendrobium species, D. nobile L. and D. officinale. The data will supply important clues to exploit useful genes involved in polysaccharide and alkaloid synthesis.

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“…Polysaccharides, the major active components of Dendrobium species, exhibited the potential as an inhibitor, including immunomodulators, antioxidants, anti‐tumor and anti‐hyperglycemic agents (Sun, Wang, & Ye, ; Sun et al, ; Wu, Xu, Chen, & Sun, ; Xiang et al, ; Yang, Lu, Hsieh, & Lin, ; Zhao, Son, Kim, Jang, & Lee, ). However, the extraction yield of polysaccharides from Dendrobium species ( D. devonianum ) on the market is still relatively low despite their average polysaccharide content up to 42.7%, which is greater than the Chinese Pharmacopoeia standard (Gan et al, ).…”

Section: Introductionmentioning

confidence: 99%

Microwave puffing assisted extraction of polysaccharides from Dendrobium devonianum

Peng

et al. 2017

J Food Process Preserv

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In this study, microwave assisted puffing technology was developed to increase the extraction efficiency of polysaccharides from D. devonianum. Fresh stems of Dendrobium devonianum were processed using microwave puffing technology and the processing conditions were explored and optimized to increase the extraction yield of polysaccharides. The effects of sample length (SL), initial moisture content (IMC), microwave power (MP), and processing time (PT) on quality attributes of the products, in terms of expansion ratio and sensory evaluation, were analyzed using response surface methodology. The optimal SL, IMC, MP, and PT were 3.5 cm, 22%, 702 W, and 31 s, respectively, which resulted in optimal expansion ratio and sensory score of 326.1% and 8.63, respectively. Furthermore, the extraction yield of polysaccharides from the microwave‐puffed products was increased by 18.9% compared with that from nonpuffed samples. Antioxidant and anti‐hyperglycemic activities of polysaccharides from puffed and nonpuffed D. devonianum were also evaluated and compared. Practical applications We developed a novel microwave assisted puffing technology to increase the extraction efficiency of polysaccharides from D. devonianum. Polysaccharides, the major active components of Dendrobium species, exhibit the potential as an inhibitor, including immunomodulator, antioxidant, anti‐tumor and anti‐hyperglycemic agent.

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Characterization and immunomodulatory activity of polysaccharides derived from Dendrobium tosaense

Cited by 53 publications

References 27 publications

Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology inDendrobiumPlants

Evaluation of Chemical Constituents and Important Mechanism of Pharmacological Biology inDendrobiumPlants

Identification and analysis of genes associated with the synthesis of bioactive constituents in Dendrobium officinale using RNA-Seq

Microwave puffing assisted extraction of polysaccharides from Dendrobium devonianum

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