Characterization and identification of PARM-1 as a new potential oncogene

Charfi, Cyndia; Levros, Louis‐Charles; Edouard, Elsy; Rassart, Éric

doi:10.1186/1476-4598-12-84

Cited by 19 publications

(20 citation statements)

References 43 publications

(66 reference statements)

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“…3d, e). 95% expressed the transcription factor Krueppel-like factor 2 (Klf2), 93% the cytoskeletal protein Vimentin (Vim) 11 and 62% the golgi/ endosomal-associated gene Prostate androgen-regulated mucinlike protein 1 (Parm1) 12 . In summary, Bsm of cluster I resemble transitional memory B cells 13,14 .…”

Section: Bsm Of Bone Marrow and Spleen Have Distinct Ig Repertoiresmentioning

confidence: 99%

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

et al. 2020

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At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1 + stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.

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Section: Bsm Of Bone Marrow and Spleen Have Distinct Ig Repertoiresmentioning

confidence: 99%

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

et al. 2020

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“…In this study, downregulation of PARM1 showed a poor prognostic outcome in PCa patients and its expression was significantly lower in PCa issue compared with benign issue in TCGA and HPA datasets. However, it is also reported that PRAM1 enhanced cell growth in leukemia 53 . The specific function of PARM1 in PCa need to be expounded further.…”

Section: Discussionmentioning

confidence: 95%

A four‐gene signature associated with clinical features can better predict prognosis in prostate cancer

et al. 2020

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Prostate cancer (PCa) is one of the most deadly urinary tumors in men globally, and the 5‐year over survival is poor due to metastasis of tumor. It is significant to explore potential biomarkers for early diagnosis and personalized therapy of PCa. In the present study, we performed an integrated analysis based on multiple microarrays in the Gene Expression Omnibus (GEO) dataset and obtained differentially expressed genes (DEGs) between 510 PCa and 259 benign issues. The weighted correlation network analysis indicated that prognostic profile was the most relevant to DEGs. Then, univariate and multivariate COX regression analyses were conducted and four prognostic genes were obtained to establish a four‐gene prognostic model. And the predictive effect and expression profiles of the four genes were well validated in another GEO dataset, The Cancer Genome Atlas and the Human Protein Atlas datasets. Furthermore, combination of four‐gene model and clinical features was analyzed systematically to guide the prognosis of patients with PCa to a largest extent. In summary, our findings indicate that four genes had important prognostic significance in PCa and combination of four‐gene model and clinical features could achieve a better prediction to guide the prognosis of patients with PCa.

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“…It has been reported that PARM1 was able to promote cardiomyogenic differentiation through regulating the BMP / Smad signaling pathway, and the activation of BMP/Smad pathway could inhibit the proliferation and growth of human CRC cells while induce cell apoptosis in CRC and prostate cancer cells . These data collectively suggest that PARM1 may function as a tumor suppressor through regulating the BMP / Smad signaling pathway in CRC although it has reported that PARM1 may function as an oncogene to enhance cell proliferation in leukemia and NIH/3T3 cells . The concept that PARM1 functions as a tumor suppressor are further supported by our current observations that PARM1 expression was significantly lower in tumor tissues compared with the noncancerous tissues and low expression of PARM1 was associated with a poorer outcome in the patients with CRC.…”

Section: Discussionmentioning

confidence: 96%

Neurexophilin and PC‐esterase domain family member 4 (NXPE4) and prostate androgen‐regulated mucin‐like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer

Liu

Zeng

et al. 2019

J of Cellular Biochemistry

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Owing to the high morbidity and mortality, novel biomarkers in the occurrence and development of colorectal cancer (CRC) are needed nowadays. In this study, the CRC‐related datasets were downloaded from the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database. After screening the differentially expressed genes (DEGs) in R software, a total of 238 upregulated and 199 downregulated DEGs were revealed simultaneously. Then the Kaplan‐Meier survival analysis and Cox regression analysis were used to reveal the prognostic function of these DEGs. Neurexophilin and PC‐esterase domain family member 4 (NXPE4) and prostate androgen‐regulated mucin‐like protein 1 (PARM1) were two outstanding independent overall survival (OS) and relapse‐free survival (RFS) prognostic genes of CRC in TCGA database. We next verified the expression of NXPE4 and PARM1 messenger RNA (mRNA) levels were significantly lower in CRC tumor tissue than in the adjacent noncancerous tissue in our clinical samples, and NXPE4 mRNA expression level was related to the tumor location and tumor size, while PARM1 was related to tumor location, lymph nodes metastasis, and tumor size. This study demonstrated that NXPE4 and PARM1 might be two potential novel prognostic biomarkers for CRC.

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Characterization and identification of PARM-1 as a new potential oncogene

Cited by 19 publications

References 43 publications

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

A four‐gene signature associated with clinical features can better predict prognosis in prostate cancer

Neurexophilin and PC‐esterase domain family member 4 (NXPE4) and prostate androgen‐regulated mucin‐like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer

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