Characterization andIn VivoBiological Performance of Biosilicate

Abstract

After an introduction showing the growing interest in glasses and glass-ceramics as biomaterials used for bone healing, we describe a new biomaterial named Biosilicate. Biosilicate is the designation of a group of fully crystallized glass-ceramics of the Na2O-CaO-SiO2-P2O5 system. Several in vitro tests have shown that Biosilicate is a very active biomaterial and that the HCA layer is formed in less than 24 hours of exposure to “simulated body fluid” (SBF) solution. Also, in vitro studies with osteoblastic cells have shown that Biosilicate disks supported significantly larger areas of calcified matrix compared to 45S5 Bioglass, indicating that this bioactive glass-ceramic may promote enhancement of in vitro bone-like tissue formation in osteogenic cell cultures. Finally, due to its special characteristics, Biosilicate has also been successfully tested in several in vivo studies. These studies revealed that the material is biocompatible, presents excellent bioactive properties, and is effective to stimulate the deposition of newly formed bone in animal models. All these data highlight the huge potential of Biosilicate to be used in bone regeneration applications.

A clinical, randomized, controlled study on the use of desensitizing agents during tooth bleaching

“…[14][15][16][17][18] In particular, the use of a new glass-ceramic powder called Biosilicate has been proposed as a therapeutic agent for enamel and dentin regeneration because of the faster deposition of a hydroxyapatite layer where the product is applied. 6,18,19 Biosilicate particles appear to react rapidly with surrounding tissue inside the dentin microchannels 18 resulting in an effective clinical reduction in sensitivity by promoting the occlusion of dentin tubules. 20 When used immediately after bleaching treatment, Biosilicate can reduce or even prevent the demineralization effect of bleaching products and prevent the exposure of dentin tubules.…”

Comparison between mineralized cancellous bone allograft and an alloplast material for sinus augmentation: A split mouth histomorphometric study

“…Renno and Vivan suggested that for satisfactory biological interaction to occur, bone replacement graft materials must not only be biocompatible but must also present a high bioactive level resulting in over 50% of living tissue (new bone) being attached to a material surface. This attachment is established through the formation of a layer of biologically active hydroxycarbonate apatite at the material/tissue interface, quite similar to bone tissue apatite.…”

Crystallization and sintering of borosilicate bioactive glasses for application in tissue engineering

“…It should be kept in mind that, while, this holds true for crystallization of typical bioactive glasses, glass-ceramic with tailored crystal composition, size and density can be produced with bioactivity similar to Bioglass ®. Biosilicate is one such material showing promising results both in-vitro and in-vivo [13]. As of today, 3D scaffold obtained via thermal bonding [14][15] and polymer foam replication [16][17][18] can be mainly classified as glass-ceramic.…”