Characterization and functional study of nuclear factor erythroid 2-related factor 2 (Nrf2) in black tiger shrimp (Penaeus monodon)

Wang, Yun; Duan, Yafei; Huang, Jianhua; Wang, Jun; Zhou, Chuanpeng; Jiang, Shigui; Lin, Heizhao; Zhang, Zhe

doi:10.1016/j.fsi.2021.10.016

Cited by 11 publications

(2 citation statements)

References 41 publications

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“…In addition to its antioxidant effects, Nrf2 has pleiotropic effects in controlling proteostasis, autophagy, mitochondrial physiology, inflammation, immune response, and cellular metabolism. [35] Of note, Nrf2 triggers Kelch-like ECH-associated protein 1 (KEAP1), which has anti-inflammatory and antioxidant effects. [36] Keap1 is R.O.S./ electrophiles biosensor.…”

Section: Nuclear Factor Erythroid 2-related Factormentioning

confidence: 99%

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The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

Al‐kuraishy,

Al‐Gareeb,

Eldahshan

et al. 2023

J Biochem & Molecular Tox

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COVID‐19 is caused by a novel SARS‐CoV‐2 leading to pulmonary and extra‐pulmonary manifestations due to oxidative stress (OS) development and hyperinflammation. COVID‐19 is primarily asymptomatic though it may cause acute lung injury (ALI), acute respiratory distress syndrome (ARDS), systemic inflammation, and thrombotic events in severe cases. SARS‐CoV‐2‐induced OS triggers the activation of different signaling pathways, which counterbalances this complication. One of these pathways is nuclear factor erythroid 2‐related factor 2 (Nrf2), which induces a series of cellular interactions to mitigate SARS‐CoV‐2‐mediated viral toxicity and OS‐induced cellular injury. Nrf2 pathway inhibits the expression of pro‐inflammatory cytokines and the development of cytokine storm in COVID‐19. Therefore, Nrf2 activators may play an essential role in reducing SARS‐CoV‐2 infection‐induced inflammation by suppressing NLRP3 inflammasome in COVID‐19. Furthermore, Nrf2 activators can attenuate endothelial dysfunction (ED), renin‐angiotensin system (RAS) dysregulation, immune thrombosis, and coagulopathy. Thus this mini‐review tries to clarify the possible role of the Nrf2 activators in the management of COVID‐19. Nrf2 activators could be an effective therapeutic strategy in the management of Covid‐19. Preclinical and clinical studies are recommended in this regard.

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Section: Nuclear Factor Erythroid 2-related Factormentioning

confidence: 99%

Section: Nuclear Factor Erythroid 2‐related Factormentioning

confidence: 99%

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

Al‐kuraishy,

Al‐Gareeb,

Eldahshan

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

Role of Nrf2-Keap1 signaling in the antioxidant defense response induced by low salinity in the kuruma shrimp (Marsupenaeus japonicus)

Liu

2022

Aquacult Int

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Characterization and functional study of nuclear factor erythroid 2-related factor 2 (Nrf2) in black tiger shrimp (Penaeus monodon)

Cited by 11 publications

References 41 publications

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

The possible role of nuclear factor erythroid‐2‐related factor 2 activators in the management of Covid‐19

Role of Nrf2-Keap1 signaling in the antioxidant defense response induced by low salinity in the kuruma shrimp (Marsupenaeus japonicus)

Effects of acute ammonia exposure on oxidative stress, endoplasmic reticulum stress and apoptosis in the kuruma shrimp (Marsupenaeus japonicus)

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