Characterization and functional correlation of multiple imaging modalities with focal choroidal excavation

Chen, Yun-Chen; Chou, Yu-Bai; Lin, Cheng‐Kuan; Tsai, Chia-Chen; Hsu, Tsui‐Kang; Chang, Yuh‐Fang; Chao, Hsiang Tai; Tung, Tao‐Hsin; Chen, Shih‐Jen; Liu, Jorn‐Hon

doi:10.1016/j.jcma.2017.07.017

Cited by 4 publications

(9 citation statements)

References 25 publications

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“…In recent years, it has been suggested that male labor is the major source of family support worldwide. It has been proposed that the male population suffers from greater psychological stress and physiologic fatigue, which are etiologies of CSCR [ 24 ]. In addition, as many articles have revealed, the mean age of CSCR onset is approximately 40 years old, which is typically a peak point in an individuals’ economic responsibilities and work commitments in their daily lives.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, higher recurrence rates were observed even if patients had received treatment. For example, following spironolactone treatment, a higher recurrence rate of approximately 48% has been noted within 3–6 months after recovery [ 24 ]. Moreover, a 24.5% recurrence rate has also been observed after photodynamic therapy in subjects with chronic CSCR [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets

Chen

Shieh

et al. 2020

Pharmaceuticals

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Purpose: To evaluate the pharmacological effects of propranolol treatment of patients with central serous chorioretinopathy (CSCR) over 4 months. Results: Among the 89 male and 31 female patients, the mean BCVA decreased to 0.42 ± 0.08 logMAR during CSCR attacks. Oral propranolol showed good effectiveness in reducing CSCR signs after at least 4 months of treatment. The final BCVA of the patients in groups 1 and 2 was 0.09 ± 0.01 and 0.19 ± 0.03 logMAR, respectively (p < 0.05). Moreover, the mean complete remission time in groups 1 and 2 was 1.9 and 3.5 months, respectively (p < 0.05), while the “success” rate in groups 1 and 2 was 95.0% (57/60) and 78.3% (47/60), respectively (p < 0.05). The recurrence rate in groups 1 and 2 was 5.3% (3/57) and 25.5% (12/47) after a further 5 months of follow-up, respectively (p < 0.05). Materials and Methods: One hundred and twenty patients were enrolled and randomly divided into two groups that both underwent a visual acuity test and optical coherence tomography (OCT) scanning, between April and December 2017. The 60 patients in group 1 were requested to take propranolol for 4 months, while the other 60 subjects (group 2) received placebo therapy during the same period. The best-corrected visual acuity (BCVA) of every volunteer and an OCT image of each patient were checked and recorded at the beginning of the study and each week thereafter. If the signs of CSCR disappeared completely from the OCT scans, the case was considered a “success” and treatment stopped at once. However, the “success” subjects were further evaluated in follow-ups throughout the next 5 months to determine the rate of recurrence in groups 1 and 2. The time of total complete remission of CSCR from the OCT scans was also measured in groups 1 and 2. Conclusion: CSCR patients revealed an excellent prognosis and success rate of 95.0% after taking propranolol. The treatment was able to enhance subretinal fluid (SRF) absorption, shorten the time to total complete remission, and significantly decrease CSCR recurrence. As such, we suggest that taking propranolol may be an alternative and viable choice for CSCR patients, given that the new method was shown to be safe, cheap, effective, well tolerated and convenient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets

Chen

Shieh

et al. 2020

Pharmaceuticals

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“…The finding may be incidental on routine examination. 46 , 53 , 54 Subjective disturbances such as metamorphopsia have been reported even in eyes with normal vision. 43 On examination of the fundus, small FCE lesions may not be apparent.…”

Section: Focal Choroidal Excavationmentioning

confidence: 99%

“…A greater length, area and volume of an FCE lesion impart greater risk of associated macular pathology. 53 , 54 Chen et al found that in multimodal imaging of FCE, the most sensitive modality was near-infrared autofluorescence (NIA), with the ability to better image subretinal and choroidal melanin loss in the form of hypoautofluorescence. A greater area of FCE on autofluorescent imaging was shown to be associated with maculopathy such as CNV and CSC.…”

Section: Focal Choroidal Excavationmentioning

confidence: 99%

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<p>Choroidal Cavitary Disorders</p>

Nassar¹,

Tarbett²,

Browning³

2020

OPTH

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The structure and functions of the choroid have been long acknowledged but the pathophysiology behind various anomalies has been difficult to understand until the advent of optical coherence tomography (OCT). With OCT imaging, choroidal cavitations appear as optically empty spaces between the outer retinal and choroidal layers with attenuation or loss of outer retinal layers. Choroidal cavitations are found in the posterior pole and seen in conditions such as pathologic myopia, north carolina macular dystrophy (NCMD), focal choroidal excavation (FCE), and torpedo maculopathy (TM). To date, these disorders have not been linked. A commonality they all share is malformation of the RPE-photoreceptor-choroid complex. The following report describes the differences and similarities of choroidal cavitation amongst the different retinal disorders and emphasizes the importance of multimodal imaging in the detection and management of potential complications.

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The role of near-infrared reflectance imaging in retinal disease: A systematic review

Sukkarieh

Lejoyeux

LeMer

et al. 2023

Survey of Ophthalmology

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Characterization and functional correlation of multiple imaging modalities with focal choroidal excavation

Cited by 4 publications

References 25 publications

Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets

Oral Treatment of Central Serous Chorioretinopathy Patients Using Propranolol Tablets

<p>Choroidal Cavitary Disorders</p>

The role of near-infrared reflectance imaging in retinal disease: A systematic review

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