Characterization and expression of melanin-concentrating hormone (MCH) in common carp (Cyprinus carpio) during fasting and reproductive cycle

Xu, Jing; Hou, Fuyuan; Wang, Debin; Li, Jun; Yang, Guangzhong

doi:10.1007/s10695-018-0586-x

Cited by 5 publications

(1 citation statement)

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“…It should be mentioned that attempts to clone the transcripts of pmch genes in some Otocephala species have not always resulted in the identification of two paralogs. In the goldfish Carassius auratus , two paralogs encoding highly similar pmch were found (Cerdá-Reverter et al, 2006), and a single paralog was found in Schizothorax prenati (Wang et al, 2016) and C. carpio (Xu et al, 2019). This apparent contradiction between the genomic databases and the attempts to clone pmch transcripts can be explained by a very low expression of pmcha , coupled to a high dissimilarity between pmcha and pmchb .…”

Section: The Mch System In the Ray-finned Fish Lineagementioning

confidence: 99%

The Melanin-Concentrating Hormone (MCH) System: A Tale of Two Peptides

Diniz

Bittencourt

2019

Front. Neurosci.

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The melanin-concentrating hormone (MCH) system is a robust integrator of exogenous and endogenous information, modulating arousal and energy balance in mammals. Its predominant function in teleosts, however, is to concentrate melanin in the scales, contributing to the adaptive color change observed in several teleost species. These contrasting functions resulted from a gene duplication that occurred after the teleost divergence, which resulted in the generation of two MCH-coding genes in this clade, which acquired distinctive sequences, distribution, and functions, examined in detail here. We also describe the distribution of MCH immunoreactivity and gene expression in a large number of species, in an attempt to identify its core elements. While initially originated as a periventricular peptide, with an intimate relationship with the third ventricle, multiple events of lateral migration occurred during evolution, making the ventrolateral and dorsolateral hypothalamus the predominant sites of MCH in teleosts and mammals, respectively. Substantial differences between species can be identified, likely reflecting differences in habitat and behavior. This observation aligns well with the idea that MCH is a major integrator of internal and external information, ensuring an appropriate response to ensure the organism's homeostasis. New studies on the MCH system in species that have not yet been investigated will help us understand more precisely how these habitat changes are connected to the hypothalamic neurochemical circuits, paving the way to new intervention strategies that may be used with pharmacological purposes.

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Section: The Mch System In the Ray-finned Fish Lineagementioning

confidence: 99%