Characterization and evaluation of silver release from four different dressings used in burns care

In vitro percutaneous penetration and characterization of silver from silver-containing textiles

“…Bianco et al on the surface of the Acticoat was also reported by Rigo et al 26 Moreover, the manufacturer declared the possibility of an inhomogeneous coating of the fibers with nanocrystals. Materials 2 and 3 showed more regular and homogeneous coverage of silver particles (Figure 2).…”

“…The silver released from material 1 was comparable to that found in the study by Rigo et al performed in a saline environment, which amounted to 4.21 µg/g (w/w Ag/saline solution). 26 An interesting review of Brett et al reported that silver concentration of about 1 mg/L shows bactericidal properties. Otherwise Greulich et al reported that the minimum inhibitory concentration (MIC) of silver against Staphylococcus aureus is in the range 2.5-5 mg/L (depending on the inoculated cell number of bacteria).…”

A holistic exploration of paediatric partial thickness burn care in the outpatient setting

“…There are many of these dressings currently available on the market [9]. These dressings are impregnated with different types of silver compounds, which are released in varying amounts from the dressing [10,56]. A survey of paediatric burns centres in Australia and New Zealand conducted as part of this thesis found that the most commonly used silver dressings are Acticoat™ and Mepilex Ag™.…”

“…Hydrofibre and alginate dressings are very rarely used for paediatric patients in Australasia. Multiple research studies [10][11][12][13][14][15] have shown silver to be effective against a variety of gram positive and negative bacteria. While it is well known that silver can be cytotoxic to healthy keratinocytes, prevention of infection, in particular toxic shock syndrome, even in small burns, is prioritized over promoting wound re-epithelialization for paediatric patients in Australia and New Zealand.…”

“…Treatment involves daily reapplications after the removal of old cream and the wound is cleaned [9]. Various SSD cream products are used in many countries worldwide as the front-line treatment for burn injuries, given their low cost, availability and anti-microbial properties [10].…”