Characterization and developmental expression of Tlx-1, the murine homolog of HOX11

A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia

“…16,[22][23][24][25] All three Hox11 family members exhibit a restricted pattern of expression, since they are expressed essentially in neural tissues during development and also in liver and pancreas of adult mice. [26][27][28][29][30] The corresponding knock-out models indicated a very specific role of these proteins during normal embryogenesis. Hox11 is a central player in controlling spleen formation, perhaps through regulating cell survival, 31,32 and the two other genes appear important for specific neuronal functions.…”

Mechanisms of transcription factor deregulation in lymphoid cell transformation

“…Similar to other HOX genes, HOX11 plays an important role in embryonic development, and functions as a master transcriptional regulator necessary for the genesis of the spleen (Roberts et al, 1994;Dear et al, 1995). In the mouse embryo, Hox11 expression can be detected in the branchial arches, restricted areas of the hindbrain and the splenic primordium (Raju et al, 1993;Roberts et al, 1995), where it is required for the survival of early splenic progenitors (Dear et al, 1995). The proposed function of HOX11 as a transcriptional regulator is supported by the presence of both a 61-amino acid, helix-turn-helix DNA-binding domain (or homeodomain) and by the localization of the HOX11 protein in the cell nucleus (Neale et al, 1995).…”

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax

“…SPE, serine, proline and glutamine acid-rich nine amino acid repeats; PHD, PHD ®ngers; ARD, acidic-rich domain; PolyQ, polyglutamine-rich region; ZNF, potential Zn ®ngers; ATA1 and ATA2, regions of homology unique to the three proteins; SET, SET domain. The two ALR proteins are encoded by alternatively spliced transcripts expression pattern in the branchial arches and trigerminal ganglia (Raju et al, 1993;Bulfone et al, 1993).…”