Characterization and Determination of Silver Nanoparticle Using Single Particle-Inductively Coupled Plasma-Mass Spectrometry

Yang, Yuan; Long, Chen-Lu; Yang, Zhaoguang; Li, Haipu; Wang, Qiang

doi:10.1016/s1872-2040(14)60777-5

Cited by 25 publications

(12 citation statements)

References 16 publications

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“…To calculate the nanoparticle concentration and size distribution, a 5σ iterative algorithm criterion, as described in our previous work, ,− was used in this study. Steps of the iterative algorithm were stated in the Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

Extraction Method Development for Quantitative Detection of Silver Nanoparticles in Environmental Soils and Sediments by Single Particle Inductively Coupled Plasma Mass Spectrometry

Wang

Yang

et al. 2019

Anal. Chem.

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For understanding the environmental behavior and toxicity of Ag nanoparticles (Ag-NPs), a quantitative method for characterizing the AgNPs in soils and sediments is urgently needed. In this study, we validated a previously developed extraction method by optimizing the extraction of silver nanoparticles from soil and sediment samples to which engineered AgNPs had been added. The samples were analyzed by single particle inductively coupled plasma mass spectrometry (SP-ICP-MS). Initially, different extraction conditions were evaluated to validate the optimal extraction procedure. Then the optimal extraction procedure was applied to environmental soil and sediment samples spiked with AgNPs. The extraction data for Ag-NPs with sizes below 30 nm was not shown due to the particle size detection limit of the SP-ICP-MS method (∼20 nm). The number concentrations of Ag particles extracted from different environmental soils and sediments matrices were in the range of (12 ± 1–23 ± 1) × 107 particles/g soil. Similarly, 53.4–100.0% of the particulate Ag mass was recovered. For the relatively low Ag mass recovery of Guiyu agricultural soil, the Ag mass recovery shows great improvement (from 53.4 to 105.8%) by the soil dilution using SiO2. The optimal method was validated to be feasible for extracting Ag-NPs from environmental soils and sediments, except for the soil with high soil organic matter (SOM) content. The SiO2 dilution of soil provides a promising way to promote the extraction of Ag-NPs in soil (or sediment) with high SOM content, which could further promote the study on the environmental behavior and toxicity of Ag-NPs in soil and sediment environment.

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Section: Methodsmentioning

confidence: 99%

Extraction Method Development for Quantitative Detection of Silver Nanoparticles in Environmental Soils and Sediments by Single Particle Inductively Coupled Plasma Mass Spectrometry

Wang

Yang

et al. 2019

Anal. Chem.

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“…The recent introduction of the single-particle (sp) acquisition mode in ICP-MS has allowed this technique to detect NPs individually, providing quantitative information on their mass distribution and number concentration in solutions [20]. A number of applications have been proposed for the characterization of AgNPs in waters [21][22][23][24][25], but biological matrices remain virtually unexplored, with the exception of enzymatically digested chicken meat [26]. However, spICP-MS does not provide key data for the dynamics of AgNPs in complex systems, including the real diameter, shape, composition and aggregation/agglomeration of the particles, because only their metallic mass can be revealed.…”

Section: Introductionmentioning

confidence: 99%

“…Offline separation of the dissolved fraction by ultrafiltration has been proposed [24,29], but simultaneous online methods would be preferable. Statistical separation of the signals generated by AgNPs and dissolved Ag is possible in spICP-MS by adopting a simple threshold value fixed on the standard deviation of the background [12,21,25,30] or by applying a more complex algorithm based on polygaussian fitting of the frequency distribution [31]. However, such strategies are not suitable for coupled techniques, in which dissolved Ag itself generates a transient signal.…”

Section: Introductionmentioning

confidence: 99%

Hydrodynamic chromatography coupled to single-particle ICP-MS for the simultaneous characterization of AgNPs and determination of dissolved Ag in plasma and blood of burn patients

et al. 2015

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Silver nanoparticles (AgNPs) are increasingly used in medical devices as innovative antibacterial agents, but no data are currently available on their chemical transformations and fate in vivo in the human body, particularly on their potential to reach the circulatory system. To study the processes involving AgNPs in human plasma and blood, we developed an analytical method based on hydrodynamic chromatography (HDC) coupled to inductively coupled plasma mass spectrometry (ICP-MS) in single-particle detection mode. An innovative algorithm was implemented to deconvolute the signals of dissolved Ag and AgNPs and to extrapolate a multiparametric characterization of the particles in the same chromatogram. From a single injection, the method provides the concentration of dissolved Ag and the distribution of AgNPs in terms of hydrodynamic diameter, mass-derived diameter, number and mass concentration. This analytical approach is robust and suitable to study quantitatively the dynamics and kinetics of AgNPs in complex biological fluids, including processes such as agglomeration, dissolution and formation of protein coronas. The method was applied to study the transformations of AgNP standards and an AgNP-coated dressing in human plasma, supported by micro X-ray fluorescence (μXRF) and micro X-ray absorption near-edge spectroscopy (μXANES) speciation analysis and imaging, and to investigate, for the first time, the possible presence of AgNPs in the blood of three burn patients treated with the same dressing. Together with our previous studies, the results strongly support the hypothesis that the systemic mobilization of the metal after topical administration of AgNPs is driven by their dissolution in situ. Graphical Abstract Simplified scheme of the combined analytical approach adopted for studying the chemical dynamics of AgNPs in human plasma/blood.

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“…This equation illustrates a linear proportional relationship between the intensities obtained from the Ti standard concentrations for particle size calibration and the respective concentrations of Ti ( c Ti ), ultimately resulting in the evaluation of d . Further spICP-MS theory has been explained elsewhere in the literature. − …”

Section: Methodsmentioning

confidence: 99%

Measurement of TiO₂ Nanoscale Ingredients in Sunscreens by Multidetector AF4, TEM, and spICP-MS Supported by Computational Modeling

Naidoo

Kanchi

Drexel

et al. 2021

ACS Appl. Nano Mater.

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There is a growing need to disclose the presence of nanostructures on the labeling of commercial products in South Africa. This work deals with complementary analytical techniques for the separation, quantification, and characterization of titanium dioxide nanoparticles (TiO 2 NPs) capped with poly(ethylene glycol) (PEG) for applications in cosmetic sunscreens. Asymmetrical flow field-flow fractionation (AF4) coupled online to multiangle light-scattering (MALS) and dynamic light-scattering (DLS) detectors has been implemented to optimize a method to evaluate the radius of gyration (r g -MALS), hydrodynamic radius (r h -DLS), and shape factor (r g /r h ) of the PEGylated TiO 2 NPs. The size distribution obtained using single-particle inductively coupled plasma mass spectrometry supported with imagery from transmission electron microscopy provided further information on the PEGcoated TiO 2 NPs in comparison to the uncapped TiO 2 NPs. Furthermore, computational adsorption studies coupled with Monte Carlo simulations provided structural insights into the spatial distribution of the curved TiO 2 NP interactions with PEG/water substrates at an atomistic and molecular level. Finally, the developed multidetector AF4 method was applied to two commercial SPF 50 sunscreens, exhibiting promising separation and detection efficiency. These findings may contribute to regulatory measures in line with the South African National Nanotechnology Strategy for the cosmetics industry.

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Characterization and Determination of Silver Nanoparticle Using Single Particle-Inductively Coupled Plasma-Mass Spectrometry

Cited by 25 publications

References 16 publications

Extraction Method Development for Quantitative Detection of Silver Nanoparticles in Environmental Soils and Sediments by Single Particle Inductively Coupled Plasma Mass Spectrometry

Extraction Method Development for Quantitative Detection of Silver Nanoparticles in Environmental Soils and Sediments by Single Particle Inductively Coupled Plasma Mass Spectrometry

Hydrodynamic chromatography coupled to single-particle ICP-MS for the simultaneous characterization of AgNPs and determination of dissolved Ag in plasma and blood of burn patients

Measurement of TiO₂ Nanoscale Ingredients in Sunscreens by Multidetector AF4, TEM, and spICP-MS Supported by Computational Modeling

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Characterization and Determination of Silver Nanoparticle Using Single Particle-Inductively Coupled Plasma-Mass Spectrometry

Cited by 25 publications

References 16 publications

Extraction Method Development for Quantitative Detection of Silver Nanoparticles in Environmental Soils and Sediments by Single Particle Inductively Coupled Plasma Mass Spectrometry

Extraction Method Development for Quantitative Detection of Silver Nanoparticles in Environmental Soils and Sediments by Single Particle Inductively Coupled Plasma Mass Spectrometry

Hydrodynamic chromatography coupled to single-particle ICP-MS for the simultaneous characterization of AgNPs and determination of dissolved Ag in plasma and blood of burn patients

Measurement of TiO2 Nanoscale Ingredients in Sunscreens by Multidetector AF4, TEM, and spICP-MS Supported by Computational Modeling

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Measurement of TiO₂ Nanoscale Ingredients in Sunscreens by Multidetector AF4, TEM, and spICP-MS Supported by Computational Modeling