Characterization and Cytotoxicity Comparison of Silver- and Silica-Based Nanostructures

Adamska, Elżbieta; Niska, Karolina; Wcisło, Anna; Grobelna, Beata

doi:10.3390/ma14174987

Cited by 9 publications

(7 citation statements)

References 62 publications

(83 reference statements)

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“…The results show that the detection performance is improved by the PEF effect of Ag@SiO 2 . In addition, as presented in ref , the cytotoxicity of Ag@SiO 2 is obviously limited due to their incorporation into a silica shell, which further demonstrates the advantages of Ag@SiO 2 in detection.…”

Section: Resultsmentioning

confidence: 63%

Dual-Mode Detection of Cysteamine Using Ag Nanoparticle-Riboflavin Composites

Song,

Liu,

Fan

et al. 2024

ACS Appl. Nano Mater.

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Riboflavin (RF) and cysteamine (Cys) are vital in clinical and other fields, but their detection is often intricate and reliant on costly equipment and materials. Plasmon-enhanced fluorescence (PEF) using plasmonic nanoparticles offers a solution to enhance the optical properties of fluorophores. Additionally, fluorescence quenching becomes apparent when the distance between the fluorophores and nanostructures shrinks to a few nanometers. Harnessing these effects holds tremendous promise for improved detection performance. In this study, the PEF of RF by Ag@SiO 2 nanoparticles was presented and used to improve RF detection. The fluorescence enhancement of RF was "turned off" in the presence of Cys because of the aggregation of Ag@SiO 2 nanoparticles caused by Cys, which can be used for the detection of Cys. On the other hand, the quenched fluorescence of RF caused by small Ag nanoparticles was "turned on" in the presence of Cys, which can further realize the detection of Cys with lower concentrations. Additionally, the color of the Ag NPs-RF composites changed in the presence of Cys, which can also be used for the colorimetric detection of Cys. A minimum detected concentration as low as 16.6 nM was realized by fluorescence and colorimetric dual-mode detection. Depending on the interactions between the plasmonic nanoparticles and Cys, the plasmonic nanoparticles show great potential for the dual-mode detection strategy in the sensitive evaluation of analytes. The dual-mode detection based on the Ag nanoparticles provides the feasibility of the nanoprobe in potential applications, which opens a promising avenue for simple, sensitive, and selective detection.

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Section: Resultsmentioning

confidence: 63%

Dual-Mode Detection of Cysteamine Using Ag Nanoparticle-Riboflavin Composites

Song,

Liu,

Fan

et al. 2024

ACS Appl. Nano Mater.

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“…In the case of gold nanoparticles, the absorption maximum is observed at a wavelength of 530 nm [26]. The same figure also shows the spectrum of silica nanoparticles, for which the maximum absorption in this range was not observed [27]. For the materials, in which the surface of gold nanoparticles is coated with a silica shell, the absorption spectra (Figure 4b) show an absorption maximum in the range of 540-550 nm, which confirms the presence of gold nanoparticles in the samples.…”

Section: Characterization Of Obtained Samplesmentioning

confidence: 69%

The Optimization of the One-Pot Synthesis of Au@SiO2 Core–Shell Nanostructures: Modification with Dansyl Group and Their Fluorescent Properties

Kowalska,

Adamska,

Synak

et al. 2024

Materials

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This work describes the optimization of the one-pot synthesis of fine core–shell nanostructures based on nanogold (Au NPs) and silica (SiO2). The obtained core–shell nanomaterials were characterized by Transmission Electron Microscopy (TEM and by the method of spectroscopes such as UV–Vis Spectroscopy and Fourier Transform Infrared Spectroscopy (FT-IR). In addition, the measurement of the zeta potential and size of the obtained particles helped present a full characterization of Au@SiO2 nanostructures. The results show that the influence of reagents acting as reducers, stabilizers, or precursors of the silica shell affects the morphology of the obtained material. By controlling the effect of the added silica precursor, the thickness of the shell can be manipulated, the reducer has an effect on the shape and variety, and then the stabilizer affects their agglomeration. This work provides also a new approach for Au@SiO2 core–shell nanostructure preparation by further modification with dansyl chloride (DNS–Cl). The results show that, by tuning the silica shell thickness, the intensity of the fluorescence spectrum of Au@SiO2–(CH2)3–NH–DNS nanocomposite is about 12 times higher than that of DNS–Cl.

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“…Certain core-shell hybrids may exhibit cytotoxic effects or trigger immune responses, limiting their therapeutic potential. For instance, gold-silica (Au-SiO 2 ) core-shell nanoparticles have been shown to induce apoptosis and cell death in certain cell lines 50 , while silver-silica (Ag-SiO 2 ) core-shell nanoparticles can elicit inflammatory responses 51 .…”

Section: Limitations Of Plasmonic Nanohybridsmentioning

confidence: 99%

Surface engineered nanohybrids in plasmonic photothermal therapy for cancer: Regulatory and translational challenges

Debnath,

Talpade

et al. 2024

Nanotheranostics

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Plasmonic materials as non-invasive and selective treatment strategies are gaining increasing attention in the healthcare sector due to their remarkable optical and electronic properties, where the interface between matter and light becomes enhanced and highly localized. Some attractive applications of plasmonic materials in healthcare include drug delivery to target specific tissues or cells, hence reducing the side effects of the drug and improving their efficacy; enhancing the contrast and resolution in bioimaging; and selectively heating and destroying the cancerous cells while parting the healthy cells. Despite such advancements in photothermal therapy for cancer treatment, some limitations are still challenging. These include poor photothermal conversion efficiency, heat resistance, less accumulation in the tumor microenvironment, poor biosafety of photothermal agents, damage to the surrounding healthy tissues, post-treatment inflammatory responses, etc. Even though the clinical application of photothermal therapy is primarily restricted due to poor tissue penetration of excitation light, enzyme therapy is hindered due to less therapeutic efficacy. Several multimodal strategies, including chemotherapy, radiotherapy, photodynamic therapy, and immunotherapy were developed to circumvent these side effects associated with plasmonic photothermal agents for effective mild-temperature photothermal therapy. It can be prophesied that the nanohybrid platform could pave the way for developing cutting-edge multifunctional precise nanomedicine via an ecologically sustainable approach towards cancer therapy. In the present review, we have highlighted the significant challenges of photothermal therapy from the laboratory to the clinical setting and their struggle to get approval from the Food and Drug Administration (FDA).

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Characterization and Cytotoxicity Comparison of Silver- and Silica-Based Nanostructures

Cited by 9 publications

References 62 publications

Dual-Mode Detection of Cysteamine Using Ag Nanoparticle-Riboflavin Composites

Dual-Mode Detection of Cysteamine Using Ag Nanoparticle-Riboflavin Composites

The Optimization of the One-Pot Synthesis of Au@SiO2 Core–Shell Nanostructures: Modification with Dansyl Group and Their Fluorescent Properties

Surface engineered nanohybrids in plasmonic photothermal therapy for cancer: Regulatory and translational challenges

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