Characterization, and comparison, of human clinical and black-headed gull (Larus ridibundus) extended-spectrum  -lactamase-producing bacterial isolates from Kalmar, on the southeast coast of Sweden

Bonnedahl, Jonas; Drobni, Peter; Johansson, Anders; Hernández, Jorge; Melhus, Åsa; Stedt, Johan; Olsén, Björn; Drobni, Mirva

doi:10.1093/jac/dkq222

Cited by 77 publications

(86 citation statements)

References 18 publications

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“…In recent years, different reports have alerted us to the spread of VRE and/or ESBL-containing E. coli isolates from clinical, farm and wild animals in different European countries (Mallon et al, 2002;Torres et al, 2003;Bonnedahl et al, 2010;Literak et al, 2010;Pinto et al, 2010). Although the percentage of vanA isolates from wild birds in the Azores was lower when compared with other studies performed in mainland Portugal in farm and wild animals (Poeta et al, 2005a;Gonçalves et al, 2010;Radhouani et al, 2010b, Radhouani et al, 2010c, our isolates showed a phenotype of multi-resistance.…”

Section: Discussionmentioning

confidence: 45%

“…In this study, the ESBLcontaining E. coli isolate, classified in the A phylogroup, was more sensitive to the antimicrobial compounds tested than ESBL-positive E. coli isolates recovered from other wild animals in mainland Portugal Poeta et al, 2009;Pinto et al, 2010;Radhouani et al, 2010a). Moreover, the b-lactamase genes detected in our isolate (bla CTX-M-14 and bla SHV-12 ) were also found in wild birds in Sweden (Bonnedahl et al, 2010) and Poland (Literak et al, 2010). How these wild birds acquired VRE and ESBL-containing E. coli is unclear.…”

Section: Discussionmentioning

confidence: 49%

“…In the past few years there has been an increase in the detection of ESBLs, mainly of the CTX-M group, in wild animals (Poeta et al, 2009;Bonnedahl et al, 2010;Pinto et al, 2010;Radhouani et al, 2010a). In this study, the ESBLcontaining E. coli isolate, classified in the A phylogroup, was more sensitive to the antimicrobial compounds tested than ESBL-positive E. coli isolates recovered from other wild animals in mainland Portugal Poeta et al, 2009;Pinto et al, 2010;Radhouani et al, 2010a).…”

Section: Discussionmentioning

confidence: 60%

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Molecular characterization of vancomycin-resistant enterococci and extended-spectrum β-lactamase-containingEscherichia coliisolates in wild birds from the Azores Archipelago

et al. 2011

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To study the prevalence of vancomycin-resistant enterococci (VRE) and extended-spectrum b-lactamase (ESBL)-containing Escherichia coli isolates, and the mechanisms of resistance implicated, 220 faecal samples from wild birds were collected between 2006 and 2010 in the Azores Archipelago. Samples were spread on SlanetzÁBartley agar plates supplemented with 4 mg/l vancomycin and on Levine agar plates supplemented with 2 mg/l cefotaxime for VRE and ESBL-containing E. coli isolation, respectively. vanA-containing enterococcal isolates (four Enterococcus faecium and two Enterococcus durans) and vanC-1 Enterococcus gallinarum isolates were detected in six and seven faecal samples, respectively. VRE isolates showed ampicillin (n 011), ciprofloxacin (n 09), tetracycline (n06), erythromycin (n 05), quinupristin/dalfopristin (n 03) and high-level kanamycin resistance (n 01). The tet(L) and/or tet(M) gene was found in all tetracycline-resistant isolates and the erm(B) gene in all erythromycin-resistant isolates. Three vanAcontaining E. faecium and two E. gallinarum presented specific sequences of the Tn5397 transposon. Four VRE isolates harboured the ace virulence gene. One faecal sample revealed one ESBL-containing E. coli isolate that belongs to the A phylogenetic group, showed a phenotype of resistance to b-lactams and tetracycline, and harboured the bla CTX-M-14 , bla SHV-12 and the tet(A) genes. To our knowledge, this is the first study to focus on defining the prevalence of VRE and/or ESBL-containing E. coli strains in wild birds from the Azores. The data recovered are essential to improve knowledge about the dissemination of resistant strains through wild ecosystems and their possible implications by transferring these resistances to other animals or to humans.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 60%

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Molecular characterization of vancomycin-resistant enterococci and extended-spectrum β-lactamase-containingEscherichia coliisolates in wild birds from the Azores Archipelago

et al. 2011

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“…Recently, E. coli ST57, ST156, and ST371, all producing ESBLs, have been recovered from chickens and turkeys in different countries in Europe and North America (Bonnedahl et al, 2010;Randall et al, 2011;Simoes et al, 2010) and ESBL-producing, verocytotoxin-producing E. coli (VTEC) isolates have also been described 10 .…”

Section: Escherichia Colimentioning

confidence: 99%

“…CTX-M-15-producing E. coli ST156 in gulls sampled in southern France, chickens and turkeys in Portugal and the UK has recently been reported (Bonnedahl et al, 2010;Randall et al, 2011;Simoes et al, 2010). CMY producers of major clonal complexes have been reported among poultry, although transmission to humans has not been demonstrated (Cortes et al, 2010).…”

Section: Escherichia Colimentioning

confidence: 99%

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

2011

EFSA Journal

240

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The potential contribution of food-producing animals or foods to public health risks by ESBL and/or AmpCproducing bacteria is related to specific plasmid-mediated ESBL and/or AmpC genes encoded by a number of organisms. The predominant ESBL families encountered are CTX-M, TEM, and SHV; the predominant AmpCfamily is CMY. The most common genes associated with this resistance in animals are bla CTX-M-1 (the most commonly identified ESBL), and bla CTX-M-14 , followed by bla and bla Among the genes encoding AmpC-type β-lactamases, bla CMY-2 is the most common.The bacterial species most commonly identified with these genes are Escherichia coli and non-typhoidal Salmonella. ESBL/AmpC transmission is mainly driven by integrons, insertion sequences, transposons and plasmids, some of which are homologous in isolates from both food-production animals and humans. Cefotaxime is used as the drug of choice for optimum detection of bla ESBL and/or bla AmpC genes. The preferred method for isolation of ESBL-and/or AmpC-producers is screening on selective agar preceded by selective enrichment in a broth.The establishment of risk factors for occurrence of ESBL/AmpC-producing bacteria is particularly complicated by the data unavailability or lack of its accuracy. The use of antimicrobials is a risk factor for the selection and spread of resistant clones, resistance genes and plasmids. Since most ESBL-and AmpC-producing strains carry additional resistances to other commonly-used veterinary drugs, generic antimicrobial use is a risk factor for ESBL/AmpC and it is not restricted specifically to the use of cephalosporins. An additional risk factor is extensive trade of animals in EU MS. There are no data on the comparative efficiency of individual control options in reducing public health risks caused by ESBL and/or AmpC-producing bacteria related to food-producing animals. Prioritisation is complex, but it is considered that a highly effective control option would be to stop all uses of cephalosporins/systemically active 3 rd /4 th generation cephalosporins, or to restrict their use (use only allowed under specific circumstances). As co-resistance is an important issue, it is also of high priority to decrease the total antimicrobial use in animal production in the EU. KEY WORDSResistance, ESBLs, AmpC, occurrence, transmission, control options, public health microbiology. SUMMARYFollowing a request from the European Commission, the Panel on Biological Hazards (BIOHAZ) was asked to deliver a Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum beta (β)-lactamases (ESBL) and/or AmpC β-lactamases (AmpC) in food and foodproducing animals. In particular, the Panel was asked: (i) to propose a definition of the ESBL-and/or AmpC-producing bacterial strains and genes relevant for public health and linked to food-producing animals or food borne transmission; (ii) to review the information on the epidemiology of acquired resistance to broad spectrum cephalosporins including the genes coding for ...

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Antimicrobial resistant and extended‐spectrum β‐lactamase producing Escherichia coli in common wild bird species in Switzerland

et al. 2019

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A total of 294 fecal swabs from 294 wild birds in Switzerland were cultivated for antimicrobial resistant (AMR) Escherichia coli. Samples were also subcultivated to detect E. coli with extended‐spectrum β‐lactamases (ESBL), carbapenemases, and plasmid‐mediated aminoglycoside or colistin resistance, respectively. Samples from 17 (5.8%) of the birds contained 19 AMR E. coli, whereof 26.3% were multidrug resistant. Five (1.7%) ESBL‐producing E. coli were detected. The isolates harbored bla CTX‐M‐1 (two isolated from carrion crows and from one great spotted woodpecker, respectively), bla CTX‐M‐15 (originating from a grey heron), bla CTX‐M‐55 (from a carrion crow), and bla CTX‐M‐65 (from a common blackbird). Phylogenetic analysis assigned three isolates to commensal phylogroups A and B1, one to extraintestinal pathogenic group B2, and one to phylogroup F. Multilocus sequence typing identified sequence types (STs) that have been found previously in ESBL E. coli in wild birds (ST58, ST205, ST540). One isolate harboring bla CTX‐M‐55 was assigned to the recently emerged fluoroquinolone‐resistant, extraintestinal pathogenic E. coli clone ST1193. Wild birds have the potential to disperse AMR, including clinically important resistance genes, from anthropogenic‐influenced habitats to diverse areas, including vulnerable natural environments such as surface waters or mountain regions.

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Characterization, and comparison, of human clinical and black-headed gull (Larus ridibundus) extended-spectrum -lactamase-producing bacterial isolates from Kalmar, on the southeast coast of Sweden

Cited by 77 publications

References 18 publications

Molecular characterization of vancomycin-resistant enterococci and extended-spectrum β-lactamase-containingEscherichia coliisolates in wild birds from the Azores Archipelago

Molecular characterization of vancomycin-resistant enterococci and extended-spectrum β-lactamase-containingEscherichia coliisolates in wild birds from the Azores Archipelago

Scientific Opinion on the public health risks of bacterial strains producing extended-spectrum β-lactamases and/or AmpC β-lactamases in food and food-producing animals

Antimicrobial resistant and extended‐spectrum β‐lactamase producing Escherichia coli in common wild bird species in Switzerland

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