“…In our present studies we can find little evidence that infection or vaccination with one serotype of the viruses used in this study induced antibody responses against the others to any important degree although there appears to be a slight cross-reaction between coxsackievirus A21 and echovirus 11. Ketler, Hamparian & Hilleman (1962) measured neutralizing antibody rises in patients infected naturally with antigenically distinct strains of rhinovirus; the responses seemed to be completely specific, but this may have been partly because only low homologous titres were detected.…”
Experiments reported here were performed on the sera of thirty-three volunteers who were infected or inoculated intranasally or intramuscularly in groups of five to nine with one of two enteroviruses, namely, echovirus 11 and coxsackievirus A21 or with one of three rhinoviruses, namely, M viruses P.K. and ECHO 28, and H virus D.C. Antibody responses occurred against the virus administered, and rarely against the other viruses used. It was concluded that although these viruses are related biologically the antibody responses in the volunteers were largely specific.
“…In our present studies we can find little evidence that infection or vaccination with one serotype of the viruses used in this study induced antibody responses against the others to any important degree although there appears to be a slight cross-reaction between coxsackievirus A21 and echovirus 11. Ketler, Hamparian & Hilleman (1962) measured neutralizing antibody rises in patients infected naturally with antigenically distinct strains of rhinovirus; the responses seemed to be completely specific, but this may have been partly because only low homologous titres were detected.…”
Experiments reported here were performed on the sera of thirty-three volunteers who were infected or inoculated intranasally or intramuscularly in groups of five to nine with one of two enteroviruses, namely, echovirus 11 and coxsackievirus A21 or with one of three rhinoviruses, namely, M viruses P.K. and ECHO 28, and H virus D.C. Antibody responses occurred against the virus administered, and rarely against the other viruses used. It was concluded that although these viruses are related biologically the antibody responses in the volunteers were largely specific.
“…The virus could therefore be said to be resistant to ether. Treatment with HCl was used by Ketler, Hamparian & Hilleman (1962) to distinguish the Coryza-Rhinovirus group from the enteroviruses. The former were inactivated by the acid conditions but the latter survived.…”
A virus was isolated from fifteen of nineteen children living in an infants' home during an outbreak of diarrhoea. The virus possesses many of the characteristics of the enterovirus group but is serologically distinct from any of the accepted members of this group. It is non-pathogenic for unweaned mice, non-cytopathic in tissue cultures of monkey kidney, but is rapidly cytopathic for tissue-cultured cells of human origin. It is serologically similar to virus Hu 659 isolated by Abrahams in the United States (personal communication).I should like to thank the Director-General of Public Health and State Psychiatric Services, New South Wales, for permission to publish.
“…The M strains most frequently isolated have proved similar to ECHO virus type 28 of which the JH strain of Price (1956), and strain 2060 of Pelon, Mogabgab, Phillips & Pierce (1956) were prototypes. A few other strains have been isolated which were different from ECHO 28; two such strains were reported by TaylorRobinson & Tyrrell (1962) and one by Ketler et al (1962).…”
mentioning
confidence: 95%
“…A few other strains have been isolated which were different from ECHO 28; two such strains were reported by TaylorRobinson & Tyrrell (1962) and one by Ketler et al (1962).…”
mentioning
confidence: 98%
“…Hamparian, Ketler & Hilleman (1961) described the isolation of eighteen strains from 110 patients; and, more recently, Ketler, Hamparian & Hilleman (1962) reported the isolation of thirty-five strains from 403 adults and children.…”
Twenty-three strains of rhinovirus were isolated from 102 patients who had common colds on arrival at a Royal Air Force recruit centre during a 6-month period from June to November, 1960. Three of these strains were M type rhino-viruses similar to ECHO 28 virus. Twenty strains were H type rhinoviruses which fell into six or more different antigenic types. Two of these types were similar to the prototypes Sal/1/58/H and Sheffield/1/60/H. Three types were antigenically distinct from those previously reported in this country and several strains are still unclassified. Other human respiratory viruses were not isolated from common colds occurring at this time among the population studied.We are indebted to the Senior Medical Officer of R.A.F. Cardington for providing facilities for the investigation, to Squadron Leader M. Shearer for his help in collecting convalescent blood specimens, and to the Director-General of the Royal Air Force Medical Service for permission to publish this paper.We wish to acknowledge the excellent technical assistance of Miss Ann Deacon. We should also like to thank Dr H. E. M. Kay of the Royal Marsden Hospital for supplying human embryo kidney.
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