Characterization and biological relevance of A 29-kDa, oestrogen receptor-related protein

King, R. J. B.; Finley, Joanne R.; Coffer, Arnold I.; Millis, Rosemary R.; Rubens, Robert

doi:10.1016/0022-4731(87)90342-6

Cited by 30 publications

(29 citation statements)

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“…The positive association between high HSP27 staining and long SR agrees well with the published literature on its association with ER (Dunn et al, 1993) and their ability to predict for hormone responsiveness of advanced breast cancer (King et al, 1987). Women with breast cancers that respond to hormone treatment have a longer survival from first relapse than those with unresponsive tumours.…”

Section: Discussionsupporting

confidence: 87%

“…Dunn & R.J.B. King, in preparation), while high levels of HSP27 in normal endometrial epithelium (King et al, 1987) and normal mammary epithelium ) correlate with proliferative activity at different stages of the menstrual cycle. Those data on normal epithelia would also suggest that HSP27 is linked to proliferation rather than to a specific hormonal environment as endometrial proliferation is stimulated by oestrogen whereas breast correlates with a progestational state (King, 1992).…”

Section: Discussionmentioning

confidence: 95%

“…We have been interested in a different type of protein, a low molecular weight (27 kDa) heat shock protein (HSP27). This is an abundant protein that has previously been discussed under three different names, p29 King et al, 1987), p24 (Ciocca et al, 1983;Adams & McGuire, 1985) and srp27 (Thor et al, 1991), but it is now known that they are one and the same protein (Mendelsohn et al, 1991;Ciocca & Luque, 1991) and will henceforth be called HSP27. HSP27 is a widely distributed protein, although levels attained in breast cancers exceed those found in other cells (Dunn et al, 1993).…”

mentioning

confidence: 99%

“…Its association to oestrogen action has been most extensively studied as HSP27 is qualitatively and quantitatively related to ER in a range of oestrogen-sensitive cells including primary breast cancers (Dunn et al, 1993). Like ER, HSP27 predicts for hormone sensitivity of advanced breast cancers (King et al, 1987) and will react with specific forms of ER (Coffer et al, 1985a;. Furthermore, HSP27 is expressed in increased amounts in invasive breast cancers as compared with carcinoma in situ, which in turn has more than normal mammary epithelium (King et al, 1987;Girling et al, 1988).…”

mentioning

confidence: 99%

“…Like ER, HSP27 predicts for hormone sensitivity of advanced breast cancers (King et al, 1987) and will react with specific forms of ER (Coffer et al, 1985a;. Furthermore, HSP27 is expressed in increased amounts in invasive breast cancers as compared with carcinoma in situ, which in turn has more than normal mammary epithelium (King et al, 1987;Girling et al, 1988).…”

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confidence: 99%

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A 27 kDa heat shock protein that has anomalous prognostic powers in early and advanced breast cancer

Love

King²

1994

Br J Cancer

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Summary This paper describes a prospective immunohistochemical analysis of 27 kDa heat shock protein (HSP27) in 361 patients with primary breast cancer in relation to disease-free survival (DFS) and survival from first relapse (SR). Oestradiol (ER) and progesterone (PR) receptors were also quantitated and related to the HSP27 data. While ER positively predicted a good outcome for both DFS and SR, HSP27 positivity predicted a prolonged SR but short DFS. The association between HSP27 and DFS only attained statistical significance in node-negative patients. Subgroup analysis reinforced the complementary relationship of HSP27 and ER for SR and opposing influences for DFS. In both node-negative and node-positive women, ER' HSP27-patients had a longer DFS than ER-HSP27+ counterparts. There was no relationship between HSP27 and overall survival. HSP27 staining was highly correlated with ER but not PR, patient age, tumour size or menstrual status. There was a marginal correlation (P = 0.04) with histological grade with welldifferentiated tumours having the highest HSP27. Cox multivariate regression analysis of the contribution of HSP27 in the presence of data on ER, PR, stage, nodal status and histological grade indicated that HSP27 was not of independent prognostic importance for DFS or overall survival and was only of borderline significance for OS (P< 0.07). However, in the absence of ER and PR data, HSP27 staining is an effective way of getting the same prognostic infonnation. HSP27 staining appears to correlate with different biological features in early and advanced breast, high HSP27 being linked with short DFS in node-negative patients but with prolonged survival from first recurrence.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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