Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers

Liu, Liang; Tang, Yuhan; Gao, Chao; Li, Yanyan; Chen, Shaodan; Xiong, Ting; Li, Juan; Du, Min; Gong, Zhiyong; Chen, Hong; Liu, Liegang; Yao, Ping

doi:10.1016/j.colsurfb.2013.11.029

Cited by 101 publications

(43 citation statements)

References 48 publications

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“…48) HPβCD combined with the lipid nanoparticles can improve the lutein loading efficiency and the partition of lutein into the porcine cornea. 49) These reports suggest CDs modified lipid vehicles as a promising tool for ocular drug delivery. The proposed mechanism of HEβCD modified NE in the lutein accumulation includes the following possibility.…”

Section: Fig 7 Cytotoxic Effects Of Lutein Loaded Vehicles On Rgc Cmentioning

confidence: 99%

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

Liu

Lai

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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Lutein is a macular pigment that contributes to maintaining eye health. The development of luteinladen nanocarriers for ocular delivery would have the advantages of user friendliness and cost-effectiveness. Nano-scaled vehicles such as cyclodextrin (CD) and nanoemulsion could overcome the barriers caused by the scleral structure. This study focused on the development of hybrid nanocarriers containing nanoemulsion and CD for scleral lutein accumulation. In the presence of the nanoemulsion, CD forms such as βCD and hydroxyethyl (HE) βCD increased the partition of lutein into the porcine sclera. A combination of nanoemulsion and 2% HEβCD enhanced lutein accumulation to 119 6 µg g 1 h 1 , which was 9.2-fold higher than that with lutein suspension alone. We explored the dose effect of CD in nanoemulsion on scleral lutein and found that the scleral accumulation of lutein was enhanced by increasing the CD content. The novel nanoemulsion had 95% drug-loading efficiency and low cytotoxicity in retinal cells. The CD-modified nanoemulsion not only improved the stability and entrapment efficacy of lutein in the aqueous system but also enhanced scleral lutein accumulation. An increase in the partition coefficient of lutein in porcine sclera when using the CDmodified nanoemulsion was also confirmed.

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Section: Fig 7 Cytotoxic Effects Of Lutein Loaded Vehicles On Rgc Cmentioning

confidence: 99%

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

Liu

Lai

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…61 Recently, cationic-modified NLC delivery systems were developed with quercetin with a particle size of ~126 nm, showing a higher bioavailability in lung, kidney, and liver tissues. 62 Although various phyto-derived antidiabetic compounds have shown a sustained release in oral studies, their bioavailability in the diabetic animal model is still limited. Thus, NLC systems can be considered as novel oral delivery systems with sustained release of the antidiabetic phyto compounds.…”

Section: Nanostructured Lipid Carriersmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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“…147 Liu et al reported that the QR-loaded cationic NLCs released QR slower than QR in solution released QR in vitro, mainly due to the slow erosion or degradation of the lipid matrix, which could prolong the residence time of the drug at the tumor site, eg, an oral cancer tumor site. 147 Nanoparticles based on noble metals, particularly gold, have an immense potential for cancer diagnosis and therapy based on their surface-plasmon resonance-enhanced light scattering and absorption. 148,149 El-Sayed et al prepared gold nanoparticles (AuNPs) by the citrate reduction of chloroauric acid.…”

mentioning

confidence: 99%

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

Calixto¹,

Fonseca-Santos²,

Chorilli³

et al. 2014

IJN

143

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Oral cancer (oral cavity and oropharynx) is a common and aggressive cancer that invades local tissue, can cause metastasis, and has a high mortality rate. Conventional treatment strategies, such as surgery and chemoradiotherapy, have improved over the past few decades; however, they remain far from optimal. Currently, cancer research is focused on improving cancer diagnosis and treatment methods (oral cavity and oropharynx) nanotechnology, which involves the design, characterization, production, and application of nanoscale drug delivery systems. In medicine, nanotechnologies, such as polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, gold nanoparticles, hydrogels, cyclodextrin complexes, and liquid crystals, are promising tools for diagnostic probes and therapeutic devices. The objective of this study is to present a systematic review of nanotechnology-based drug delivery systems for oral cancers.

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Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers

Cited by 101 publications

References 48 publications

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

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Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers

Cited by 101 publications

References 48 publications

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

<i>In Vitro</i> Scleral Lutein Distribution by Cyclodextrin Containing Nanoemulsions

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

Nanotechnology-based drug delivery systems for treatment of oral cancer: a review

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status