Characterization and biocompatibility study of hydroxyapatite coating on the surface of titanium alloy

Jiang, Jinchun; Han, Gui Young; Zheng, Xuesong; Chen, Gang; Zhu, Peizhi

doi:10.1016/j.surfcoat.2019.07.067

Cited by 40 publications

(17 citation statements)

References 54 publications

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“…It has been reported that HA affects the early bone regeneration process in a positive manner by increasing the new bond formation at implant-tissue interface and accelerating cell proliferation 61. Therefore, nHA deposits formed on the Ti surfaces have the potency to increase the bond strength and promote the new bone generation.…”

Section: Discussionmentioning

confidence: 99%

A functional coating to enhance antibacterial and bioactivity properties of titanium implants and its performance in vitro

et al. 2020

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Bacterial infections and lack of osseointegration may negatively affect the success of titanium (Ti) implants. In the present study, a functional coating composed of chitosan (CS) microspheres and nano hydroxyapatite (nHA) was prepared to obtain antimicrobial Ti implants with enhanced bioactivity. First, the chitosan microspheres were fixed to Ti surfaces activated by alkali and heat treatment, then nHA coatings were precipitated onto these surfaces. Ciprofloxacin was loaded into the microspheres using two different procedures; encapsulation and diffusion. Scanning electron microscopy micrographs of the modified Ti surfaces showed that the coating was successfully deposited onto the Ti surfaces and stable for 30 days in PBS. The drug was completely released from free microspheres loaded by encapsulation in 21 days whereas only 89% release was observed after immobilization. The burst release also decreased from ca. 55% to ca. 35%. The release was further reduced following the nHA precipitation. The modified Ti surfaces showed antimicrobial activity based on the bacterial time-kill assay using S. aureus, but the efficiency was affected by both nHA precipitation and drug loading strategy. Highest antimicrobial activity was seen in the samples without nHA layer, and when the drug was loaded by diffusion. Fourier transform infrared spectroscopy and X-ray diffraction analyses revealed that nHA on the surface enhanced HA growth in simulated body fluid for 3 weeks, showing increased osseointegration potential. Therefore, the proposed coating may be used to prevent Ti implant failure originated from bacterial infection and/or low bioactivity.

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Section: Discussionmentioning

confidence: 99%

A functional coating to enhance antibacterial and bioactivity properties of titanium implants and its performance in vitro

et al. 2020

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“…Saline [28] Sodium hypochlorite [26] Sodium hydroxide [33] Improve osteoconduction and osteointegration [33] Enhance early stage of cell adhesion, proliferation, and differentiation [34] Cause precipitation of many minerals, higher wear resistance of the implant surface [28,[33][34][35] Aluminium Sand-blasting [37] Acid etching [37] Physiological fluids [15] Ti-Al coating [38] Enhance corrosion resistant [15] Improved osteoblast viability [22] Interfere osseointegration process [39] [15,22,[37][38][39]…”

Section: Sodiummentioning

confidence: 99%

“…The nanoporous hydroxyapatite/ sodium titanate bilayer has been reported to improve invivo osteoconduction and osteointegration [33]. Moreover, the treatment of hydrophilicity of Ti discs using NaOH tend to enhance the early stages of cell adhesion, proliferation, and differentiation [34]. In one study, SBF solution has been used during a coating procedure for Ti implants, causing precipitation of many minerals (e.g.…”

Section: Sodium (Na)mentioning

confidence: 99%

Contamination of titanium dental implants: a narrative review

et al. 2020

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Contamination of titanium dental implants may lead to implant failure. There are two major types of contaminants: the inorganic and organic contaminants. The inorganic contaminants mostly consist of elements such as calcium, phosphorus, chlorine, sulphur, sodium, silicon, fluorine and some organic carbons. Whereas organic contaminants consist of hydrocarbon, carboxylates, salts of organic acids, nitrogen from ammonium and bacterial cells/byproducts. Contaminants can alter the surface energy, chemical purity, thickness and composition of the oxide layer, however, we lack clinical evidence that contaminations have any effect at all. However, surface cleanliness seems to be essential for implant osseointegration.These contaminants may cause dental implants to fail in its function to restore missing teeth and also cause a financial burden to the patient and the health care services to invest in decontamination methods. Therefore, it is important to discuss the aetiology of dental implant failures. In this narrative review, we discuss two major types of contaminants: the inorganic and organic contaminants including bacterial contaminants. This review also aims to discuss the potential effect of contamination on Ti dental implants.

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“…This similarity makes it the preferred candidate for orthopedic and dental implants [6]. Hence, HAP coating allows for new surface properties such as osteointegration and biocompatibility [6][7][8], which lead to an improvement in implant functionality. Several techniques have been developed for coating metal implants, including plasma spraying sputtering [2], sol-gel [5], electrophoretic deposition [9], magnetron sputtering [10], LVOF (Low-Velocity Oxyfuel) sprayed [11], and electrodeposition [12,13].…”

Section: Introductionmentioning

confidence: 99%

Nanomechanical Behavior, Adhesion and Corrosion Resistance of Hydroxyapatite Coatings for Orthopedic Implant Applications

et al. 2021

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The aim of this work was to investigate the nanomechanical, adhesion and corrosion resistance of hydroxyapatite (HAP) coatings. The electrodeposition process was used to elaborate the HAP coatings on Ti6Al4V alloy. The effect of hydrogen peroxide concentration H2O2 on the electrolyte and the heat treatment was studied. Surface morphology of HAP coatings was assessed, before and after heat treatment, by scanning electron microscopy associated with X-ray microanalysis (SEM-EDXS). Moreover, X-ray diffraction (XRD) was performed to identify the coatings’ phases and composition. Nanoindentation and scratch tests were performed for nanomechanical and adhesion behavior analysis. The corrosion resistance of the uncoated, the as-deposited, and the heat-treated coatings was investigated by electrochemical test. The obtained results revealed that, with 9% of H2O2 and after heat treatment, the HAP film exhibited a compact and homogeneous microstructure. The film also showed a crystal growth: stoichiometric hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP). After heat treatment, the nanomechanical properties (H, E) were increased from 117 ± 7 MPa and 24 ± 1 GPa to 171 ± 10 MPa and 38 ± 1.5 GPa respectively. Critical loads (LC1, LC2, and LC3) were increased from 0.78 ± 0.04, 1.6 ± 0.01, and 4 ± 0.23 N to 1.45 ± 0.08, 2.46 ± 0.14, and 4.35 ± 0.25 N (respectively). Furthermore, the adhesion strength increased from 8 to 13 MPa after heat treatment. The HAP heat-treated samples showed higher corrosion resistance (Rp = 65.85 kΩ/cm2; Icorr = 0.63 µA/cm2; Ecorr = −167 mV/ECS) compared to as-deposited and uncoated samples.

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Characterization and biocompatibility study of hydroxyapatite coating on the surface of titanium alloy

Cited by 40 publications

References 54 publications

A functional coating to enhance antibacterial and bioactivity properties of titanium implants and its performance in vitro

A functional coating to enhance antibacterial and bioactivity properties of titanium implants and its performance in vitro

Contamination of titanium dental implants: a narrative review

Nanomechanical Behavior, Adhesion and Corrosion Resistance of Hydroxyapatite Coatings for Orthopedic Implant Applications

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