“…According to previous reports, the incorporation of peptide nisin onto the matrix of the biomolecule is solely determined from amide I (stretching vibration, C O bond) and amide II (bending vibration of the N–H bonds) vibrations of the peptide. 20 In the case of a nanoconjugate, the peak observed at 1635 cm −1 in the IR spectrum corresponds to the amide I band vibrations due to the unordered beta-turn of pure nisin ( Fig. 1g ).…”
A facile approach towards the formulation of antimicrobial peptide adsorbed magnetic nano-conjugates with oxidative stress mediated bacterial cell death.
“…According to previous reports, the incorporation of peptide nisin onto the matrix of the biomolecule is solely determined from amide I (stretching vibration, C O bond) and amide II (bending vibration of the N–H bonds) vibrations of the peptide. 20 In the case of a nanoconjugate, the peak observed at 1635 cm −1 in the IR spectrum corresponds to the amide I band vibrations due to the unordered beta-turn of pure nisin ( Fig. 1g ).…”
A facile approach towards the formulation of antimicrobial peptide adsorbed magnetic nano-conjugates with oxidative stress mediated bacterial cell death.
“…Owing to antibiotic overuse in the medical, fishery, and livestock and poultry breeding industry, several antibioticresistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Streptococcus pneumoniae (MDRSP), and vancomycin-resistant Enterococcus (VRE) have emerged, posing new challenges to food hygiene and safety and efficacy of medicines (Gomes et al, 2022;Kim & Ahn, 2022;Le et al, 2022). To overcome the challenges posed by the increasing emergence of drug-resistant bacteria and their strong environmental adaptability, researchers are using a combination of antibiotics to treat bacterial infections (Beardmore et al, 2017;Li et al, 2022b;Pabon et al, 2022). In recent years, many researchers have focused on identifying natural antibacterial substances.…”
Section: The Challenge Of Antibiotic-resistant Microorganismsmentioning
Oridonin is an enantiomer-kaurene tetracyclic diterpenoid compound, which is the main active component of Rabdosia rubescens, a herb used in traditional Chinese medicine. It has been reported to exert anti-tumor, anti-inflammatory, proapoptotic, anti-angiogenic, neuroprotective, and other pharmacological effects. Owing to the overuse of antibiotics, currently, the medical and food industries are facing drug resistance challenges, which have severely impacted food and medical safety. Thus, new antibacterial agents must be identified. As an important active component of Rabdosia rubescens, oridonin has been extensively and deeply studied in antimicrobial aspects. This paper reviews the antimicrobial activity of oridonin and its underlying mechanism. In addition, its safety and application as an antibacterial agent were briefly introduced. Finally, the current problems and challenges of the application of oridonin and the prospects were also elucidated.
“…Researchers have exhibited the synergistic effect of nisin and plant compounds against food pathogens (Abdollahzadeh et al., 2014 ; Liu et al., 2020 ; Pabon et al., 2021 ; Panahi & Mohsenzadeh, 2022 ; Solomakos et al., 2008 ; Zhang et al., 2014 ). However, to the best of the authors' knowledge, no previous studies were found on the co‐encapsulation of any essential oil and nisin into nano/microgel chitosan as an antimicrobial and antioxidant agent to enhance the shelf‐life of cheese.…”
The current study aims to co‐encapsulate Shirazi thyme (Zataria multiflora) essential oil (ZEO) and nisin into chitosan nanogel as an antimicrobial and antioxidant agent to enhance the shelf‐life of cheese. Chitosan‐caffeic acid (CS‐CA) nanogel was produced to co‐encapsulate Zataria multiflora essential oil and nisin. This nanogel was characterized by dynamic light scattering (DLS), Fourier Transform Infrared (FTIR) spectroscopic analysis, X‐ray diffraction (XRD) analysis, and scanning electron microscopy (SEM) images. The effect of free (TFZN) and encapsulated ZEO‐nisin in chitosan nanogel (TCZN) on the chemical and microbiological properties of Iranian white cheese was assessed. The particle size, polydispersity index value (PDI), zeta potential, antioxidant activity, and encapsulation efficiency of the optimal chitosan‐ZEO‐nisin nanogel were 421.6 nm, 0.343, 34.0 mV, 71.06%–82.69%, and 41.3 ± 0.5%, 0.79 ± 0.06 mg/mL. respectively. FTIR and XRD approved ZEO and nisin entrapment within chitosan nanogel. The chitosan nanogel showed a highly porous surface with an irregular shape. The bioactive compounds of ZEO and nisin decreased the pH changes in cheese. On the 60th day of storage, the acidity of treated samples was significantly lower than that of control. Although the lowest anisidine index value was observed in samples treated with sodium nitrate (NaNO3) (TS), there was no significant difference between this sample and TCZN. The lowest microbial population was observed in TCZN and TS. After 60 days of ripening, Coliforms were not detected in the culture medium of TCZN and TS. The results can contribute to the development of a natural preservative with the potential for application in the dairy industry.
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