Characterization and Antibiotic Sensitivity Profile of Bacteria Isolated from Patients with Respiratory Tract Infections in Bangladesh

Abstract

ABSTRACT:The study was aimed to characterize bacterial isolates from respiratory tract infections (RTI) and investigate their antibiotic sensitivity profile. Selective media and biochemical tests were used to characterize 40 bacterial isolates. Antibiotic sensitivity testing was conducted using Kirby-Bauer disc diffusion method. About 42.5% (17) RTI patients were infected by Klebsiella pneumoniae, 30% (12) by Escherichia coli and 27.5% (11) by Pseudomonas aeruginosa with no significant gender variation (p-value <0.578). Overall, 47% (out of 20) antibiotics were sensitive, whereas 48% were resistant. Surprisingly, 18% P. aeruginosa and 20% K. pneumoniae were carbapenem-resistant and 4 out of 7 cephalosporin antibiotics were highly resistant irrespective of pathogens. E. coli showed better sensitivity to nitrofurantoin (78%) and levofloxacin (89%), while K. pneumoniae was insensitive to cotrimoxazole (88%), gentamycin (77%) and piperacillin/tazobactam (66%). On the other hand, P. aeruginosa did not respond to P. aeruginosa to nalidixic acid (60%) and ciprofloxacin (60%). This study concludes that nitrofurantoin, levofloxacin, cotrimoxazole, gentamycin and piperacillin/tazobactam antibiotics could be better alternative in treating bacterial RTIs.

Antimicrobial Sensitivity of Bacterial Species Isolated from Blood, Respiratory and Pus Samples

“…Further, the present study observed that Klebsiella spp. was the predominant bacterial isolate from the respiratory samples and similar observations were documented from the different healthcare settings of the world [7][8][9][10][11].…”

Antibiotic sensitivity pattern of bacterial isolates from sputum samples of admitted patients with acute lower respiratory tract infections in a tertiary care teaching hospital of Tripura: a hospital record-based study

“…Klebsiella was also found as predominant organism in studies done by Ahmed et al, Promite et al and Manikandan et al showing 59.7%, 42.5% and 28.4% frequency respectively. [5][6][7] In this study, the other common isolated pathogens were Acinetobacter (13.49%) and Pseudomonas (13.23%). This finding correlates with the findings of Ali et al 8 showing prevalence of Acinetobacter and Pseudomonas to be 13.69% and 35.35% respectively.…”

“…Amikacin and gentamycin were found to be sensitive to Klebsiella in other studies. 6,10 Acinetobacter was sensitive to many antibiotics e.g., imipenem, piperacillin/tazobactam, cefuroxime etc. but the association was not significant.…”

Antibiotic Resistance Pattern in Respiratory Tract Infection during COVID-19 Era

“…Klebsiella was the predominant microorganism isolated from these samples (45.2%). Klebsiella was also found as a predominant organism in studies done by [12][13][14][15] Another previous study which was conducted in the same institution two years before also reported that Klebsiella was the most commonly isolated organism from the sputum samples of hospitalized patients with community-acquired pneumonia. 16 In this study, the other common isolated pathogens were Pseudomonas (17.3%) and Acinetobacter (14.4%).…”