Characterization and antibacterial activity of the essential oil obtained from the leaves of Baccharis coridifolia DC against multiresistant strains

Freitas, Priscilla Ramos; Araújo, Ana Carolina Justino de; Barbosa, Cristina Rodrigues dos Santos; Muniz, Débora Feitosa; Rocha, Janaína Esmeraldo; Neto, José Bezerra de Araújo; Silva, Maria Milene Costa da; Pereira, Raimundo Luiz Silva; Silva, Luiz Everson da; Amaral, Wanderlei do; Deschamps, Cícero; Tintino, Saulo Relison; Ribeiro-Filho, Jaime; Coutinho, Henrique Douglas Melo

doi:10.1016/j.micpath.2020.104223

Cited by 27 publications

(19 citation statements)

References 28 publications

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“…The main damage is the cell membrane disruption, also linked to the inhibition of efflux pumps responsible for antibiotic resistance in Gram-negative bacteria, but other modes of action have been widely reported, such as the inhibition of the peptidoglycan layer synthesis of bacterial cell walls by binding to PBPs for Gram-positive bacteria [16][17][18][19][20]. Their antibacterial activity has been recently studied against pathogenic bacteria frequently responsible for hospital-acquired infections (HAIs) [21][22][23][24][25]. Recent studies have also highlighted the synergistic action of EOs with other antimicrobial drugs and how these associations could be used to positively modulate the antimicrobial activity of some antibiotics against antibiotic-resistant bacteria, with a consequent decrease in the minimum effective dose of the drugs [26][27][28][29][30][31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections

et al. 2021

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The emergence of antibiotic-resistant bacteria has become a major concern worldwide. This trend indicates the need for alternative agents to antibiotics, such as natural compounds of plant origin. Using agar disc diffusion and minimum inhibitory concentration (MIC) assays, we investigated the antimicrobial activity of Citrus aurantium (AEO), Citrus x limon (LEO), Eucalyptus globulus (EEO), Melaleuca alternifolia (TTO), and Cupressus sempervirens (CEO) essential oils (EOs) against three representatives of antibiotic-resistant pathogens and respective biofilms: vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and extended-spectrum β-lactamase (ESBL)-producing Escherichia coli. Using the checkerboard method, the efficacy of the EOs alone, in an association with each other, or in combination with the reference antibiotics was quantified by calculating fractional inhibitory concentrations (FICs). All the EOs displayed antibacterial activity against all strains to different extents, and TTO was the most effective. The results of the EO–EO associations and EO–antibiotic combinations clearly showed a synergistic outcome in most tests. Lastly, the effectiveness of EOs both alone and in association or combination against biofilm formed by the antibiotic-resistant strains was comparable to, and sometimes better than, that of the reference antibiotics. In conclusion, the combination of EOs and antibiotics represents a promising therapeutic strategy against antibiotic-resistant bacteria, even protected inside biofilms, which can allow decreasing the concentrations of antibiotics used.

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Section: Introductionmentioning

confidence: 99%

Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections

et al. 2021

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“…As plantas possuem mecanismos naturais contra insetos, os chamados metabólitos secundários, e possuem funções de adaptar o organismo vegetal ao habitat em que vivem. Os metabólitos secundários protegem as plantas contra o ataque de pragas e infecções microbianas, além de apresentar características fitoterápicas (Freitas et al, 2020).…”

Section: Introductionunclassified

O uso de óleos essenciais para o controle de pragas do milho

Mattos

Krewer

Eccel

et al. 2021

Estr

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O Brasil é um dos maiores produtores de milho mundial. O clima e o surgimento de pragas são fatores que interferem na quantidade e qualidade desta produção agrícola. No que refere-se às pragas presentes nas lavouras, o seu combate com a utilização de agrotóxicos demonstra-se eficiente, no entanto, se mal-empregados, podem oferecer riscos à saúde humana e ao meio ambiente. Diversos estudos apontam os óleos essenciais como alternativa para substituição ao uso de agrotóxicos. A proposta deste trabalho consistiu em apresentar uma revisão bibliográfica a respeito da eficiência da utilização de óleos essenciais com efeito inseticida e repelente para o combate às diferentes pragas do milho. Os resultados demonstram que o óleo essencial de Baccharis dracunculifolia apresentou efeito inseticida significativo em aplicação contra os insetos; o óleo essencial do alecrim-pimenta pode ser utilizado como controle alternativo contra o fungo Curvularia; o óleo essencial das folhas de mentrasto apresentou um resultado precoce no controle da lagarta-do-cartucho; o óleo essencial das folhas da aroeira-salso apresentou eficiência no controle do gorgulho-do-milho, assim como o óleo essencial de cravo-de-defunto também apresentou resultado positivo no combate a esta praga. O óleo essencial de folhas de pimenta-longa possui atividade inseticida contra a lagarta-do-cartucho com eficiência na mortalidade. Os óleos essenciais do marmeleio, velame, aroeira e manjericão apresentou resultados positivos no combate ao besouro-castanho; os óleos essenciais de citronela, tomilho, capim-limão, eucalipto, canela e cravo controlam com eficiência a germinação de conídios e o crescimento micelial nas sementes do milho. Os óleos essenciais de cravo-da-índia e canela reduziram a incidência de patógenos e os óleos essenciais de cravo-da-índia e tomilho atuaram diretamente no controle do fungo conídio. Ainda, os óleos essenciais de eucaliptos revelaram-se promissores na proteção de plantações quando pulverizados nas mesmas. Ou seja, diversos óleos essenciais apresentaram diferentes aplicabilidades no controle das pragas do milho.

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“…Pseudomonas aeruginosa are Gram-negative bacteria with high virulence. These are only some examples of bacteria that act as opportunistic microorganisms that can cause severe infections and even sepsis [6]. According to data obtained by the World Health Organization (WHO), the ability of bacteria to resist to the available antibiotics causes about 700 thousand death per year and it is estimated that this number will increase considerably, reaching 10 million deaths per year by 2050.…”

Section: Introductionmentioning

confidence: 99%

“…Besides this, antimicrobial resistance will have economic implications: studies show that the world may lose between 60 and 100 trillion dollars in economic production, which represents a decrease of 2.0 to 3.5% of global gross domestic product (GDP) expected for 2050 [3]. This scenario has led to the development of research aimed at identifying new antimicrobial agents through chemical synthesis or isolation from natural products [6].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial Activity of Phenolic Compounds Extracted from <em>Platanus hybrida</em>: Exploring Alternative Therapies for a Post-Antibiotic Era

Ribeiro

Silva

Aires

et al. 2020

Proceedings of 1st International Electronic Conference on Microbiology

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Multidrug-resistant bacteria are a significant threat to public health and new classes of antibiotics and approaches to treatment are needed. Several studies showed that natural plantderived compounds could be a promising mean to fight microbial resistance but only a few were conducted with antibiotic resistant bacteria. Therefore, the aim of this study was to extract phenolic compounds from the leaves, fruits and tree trunk of Platanus hybrida and evaluate their antimicrobial activity against antibiotic resistant bacterial strains. The polyphenolic compounds were extracted using a water/ethanol (20:80) mixture. Two grams of powder of each sample was extracted with 100 mL of solvent by stirring for 2h. The extracts were redissolved in dimethyl sulfoxide (DMSO) to a final concentration of 100 mg/mL. Antimicrobial susceptibility assay was performed using Kirby-Bauer disc diffusion method and was tested against ten different bacteria: Listeria monocytes, Bacillus cereus, Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Salmonella enteritidis, Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli. The fruits had the highest antibacterial activity showing a minimum inhibitory concentration (MIC) of 10mg/mL, contrary to the tree trunk that showed the lowest antibacterial activity. None of the extracts showed antimicrobial properties against S. enteritidis, E. faecium and E. faecalis. These results show that, P. hybrida's phenolic compounds act as antibacterial agents which may become useful therapeutic tools and represent a source for the development of novel antimicrobials. However, they were not effective against all bacteria which shows that polyphenols, alone, might not substitute antibiotics.

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Characterization and antibacterial activity of the essential oil obtained from the leaves of Baccharis coridifolia DC against multiresistant strains

Cited by 27 publications

References 28 publications

Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections

Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections

O uso de óleos essenciais para o controle de pragas do milho

Antimicrobial Activity of Phenolic Compounds Extracted from <em>Platanus hybrida</em>: Exploring Alternative Therapies for a Post-Antibiotic Era

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Characterization and antibacterial activity of the essential oil obtained from the leaves of Baccharis coridifolia DC against multiresistant strains

Cited by 27 publications

References 28 publications

Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections

Essential Oils: A Natural Weapon against Antibiotic-Resistant Bacteria Responsible for Nosocomial Infections

O uso de óleos essenciais para o controle de pragas do milho

Antimicrobial Activity of Phenolic Compounds Extracted from &lt;em&gt;Platanus hybrida&lt;/em&gt;: Exploring Alternative Therapies for a Post-Antibiotic Era

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Antimicrobial Activity of Phenolic Compounds Extracted from <em>Platanus hybrida</em>: Exploring Alternative Therapies for a Post-Antibiotic Era