Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats

Zhao, Kaijing; Yang, Chen; Hong, Shijin; Yang, Yiting; Xu, Jing; Yang, Hanyu; Zhu, Liang; Liu, Ming; Xie, Qian; Tang, Xin; Yang, Tingting; Zhou, Yaqian; Liu, Li; Liu, Xiaodong

doi:10.1038/s41401-019-0218-8

Cited by 5 publications

(2 citation statements)

References 44 publications

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“…However, no significant decrease in uranium content was observed in the liver, possibly due to the kinetics of CD drug metabolism in the organism. 55,56 In contrast, DTPA exhibited limited efficacy in removing uranium, resulting in an 18.3% decrease in the kidneys, 11.5% in the femurs, 19.0% in the spleens, 5.9% in the livers, and 12.5% in the muscles (Figure 4c,d).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation

Liu,

Zhao,

et al. 2024

Inorg. Chem.

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Uranium accumulation in the kidneys and bones following internal contamination results in severe damage, emphasizing the pressing need for the discovery of actinide decorporation agents with efficient removal of uranium and low toxicity. In this work, cinnamic acid (3-phenyl-2-propenoic acid, CD), a natural aromatic carboxylic acid, is investigated as a potential uranium decorporation ligand. CD demonstrates markedly lower cytotoxicity than that of diethylenetriaminepentaacetic acid (DTPA), an actinide decorporation agent approved by the FDA, and effectively removes approximately 44.5% of uranyl from NRK-52E cells. More importantly, the results of the prompt administration of the CD solution remove 48.2 and 27.3% of uranyl from the kidneys and femurs of mice, respectively. Assessments of serum renal function reveal the potential of CD to ameliorate uranyl-induced renal injury. Furthermore, the single crystal of CD and uranyl compound (C9H7O2)2·UO2 (denoted as UO2–CD) reveals the formation of uranyl dimers as secondary building units. Thermodynamic analysis of the solution shows that CD coordinates with uranyl to form a 2:1 molar ratio complex at a physiological pH of 7.4. Density functional theory (DFT) calculations further show that CD exhibits a significant 7-fold heightened affinity for uranyl binding in comparison to DTPA.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation

Liu,

Zhao,

et al. 2024

Inorg. Chem.

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“…The administration of sodium benzoate causes a strong but transient increase in anthranilic acid (involved in tryptophan metabolism) and acetylglycine. The benzoate is one of the cinnamon metabolites [ 9 , 10 ]. Cinnamon contains cinnamaldehyde, which is converts to cinnamic acid in the liver and is then β-oxidized to benzoate (sodium salt or benzoyl-CoA).…”

Section: Introductionmentioning

confidence: 99%

Sodium Benzoate—Harmfulness and Potential Use in Therapies for Disorders Related to the Nervous System: A Review

Walczak-Nowicka

Herbet

2022

Nutrients

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Currently, due to the large number of reports regarding the harmfulness of food additives, more and more consumers follow the so-called “clean label” trend, i.e., prefer and choose the least-processed food products. One of the compounds known as a preservative with a high safety profile is sodium benzoate. While some studies show that it can be used to treat conditions such as depression, pain, schizophrenia, autism spectrum disorders, and neurodegenerative diseases, others report its harmfulness. For example, it was found to cause mutagenic effects, generate oxidative stress, disrupt hormones, and reduce fertility. Due to such disparate results, the purpose of this study is to comprehensively discuss the safety profile of sodium benzoate and its potential use in neurodegenerative diseases, especially in autism spectrum disorder (ASD), schizophrenia, major depressive disorder (MDD), and pain relief.

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Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury

Jiang,

Sun,

Wang

et al. 2024

Acta Pharmacol Sin

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Characteristics of β-oxidative and reductive metabolism on the acyl side chain of cinnamic acid and its analogues in rats

Cited by 5 publications

References 44 publications

Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation

Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation

Sodium Benzoate—Harmfulness and Potential Use in Therapies for Disorders Related to the Nervous System: A Review

Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury

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