Characteristics of Veterans diagnosed with seizures within Veterans Health Administration

Rehman, Rizwana; Kelly, Pat; Husain, Aatif M.; Tran, Tung Thanh

doi:10.1682/jrrd.2014.10.0241

Cited by 11 publications

(10 citation statements)

References 24 publications

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“…Sensitivity analysis did not reveal any significant single-study effect on the magnitude or direction of association. Although there were no previous similar reviews to compare our study findings, these findings were in line with the findings of a majority of the studies included in the review 7,8,15,16,21–26…”

Section: Discussionsupporting

confidence: 91%

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Risk of Epilepsy Following Traumatic Brain Injury: A Systematic Review and Meta-analysis

Sui

Sun

Chen

et al. 2022

Journal of Head Trauma Rehabilitation

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Background: Limited evidence has explored the impact of traumatic brain injury (TBI) on posttraumatic epilepsy with control cohort for comparison. In addition, we could not find any review to identify the effect of TBI on the outcomes. Thus, we conducted this study to compare the risk of epilepsy between individuals with TBI and without TBI. Methods: Systematic and comprehensive search was carried out in the following databases and search engines: EMBASE, Cochrane, MEDLINE, ScienceDirect, and Google Scholar from 1954 until January 2022. The Newcastle Ottawa (NO) Scale was utilized to assess the risk of bias. Meta-analysis was carried out using the random-effects model, and pooled odds ratio (OR) along with 95% CI was reported. Results: In total, we included 10 studies satisfying inclusion criteria. Most studies had good to satisfactory quality. The pooled OR was 4.25 (95% CI, 1.77-10.25; I 2 = 100%), indicating that the individuals with TBI had 4.25 times higher risk of having epilepsy than individuals without TBI, and this association was statistically significant (P = .001). Subgroup analysis based on the years of follow-up revealed that the patients within 5 years post-TBI had the highest risk of epilepsy (pooled OR = 7.27; 95% CI, 3.61-14.64). Conclusion: Individuals with TBI had a significantly higher risk of epilepsy than the individuals without TBI, irrespective of the duration of the injury. Hence, long-term follow-up of the individuals with TBI is necessary to prevent any adverse consequences.

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Section: Discussionsupporting

confidence: 91%

“…After final screening against eligibility criteria, the final consensus was reached for including 10 studies containing 9.8 million participants (see Figure 1). 7,8,15,16,[21][22][23][24][25][26]…”

Section: Study Selectionmentioning

confidence: 99%

Risk of Epilepsy Following Traumatic Brain Injury: A Systematic Review and Meta-analysis

Sui

Sun

Chen

et al. 2022

Journal of Head Trauma Rehabilitation

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“…Within this older onset age subgroup, a different gender ratio has been reported [2,23]; similar variations have been observed in certain occupations (e.g. military veterans) [24]. As for psychological trauma, approximately 30% of patients deny this type of experience and a small percentage fulfill criteria for PTSD [25], and other psychiatric comorbidities are not always present either.…”

Section: Introductionmentioning

confidence: 58%

A descriptive study of patients diagnosed with psychogenic nonepileptic seizures at a tertiary epilepsy center in the Czech Republic: One-year follow-up

Krámská

Myers

Hrešková

et al. 2021

Epilepsy & Behavior

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To delineate sociodemographic data of a large sample of Czech Republic patients diagnosed with psychogenic non-epileptic seizures (PNES) at the time of diagnosis and at a follow-up visit one year after discharge.This study collected reports of past stressors, quality of relationships in childhood, family background, traumatic events, and recent adversities in patients diagnosed with PNES. Method: Patients (219w/79m, 37.56 (13.15) years, 12.13 (2.05) years of education) were assessed through a semi-structured interview on clinical and historical data while they were inpatients at the Epilepsy Center, Na Homolce Hospital, Prague. Subsequently, they were re-evaluated one year after discharge from the hospital with the same method. A comparison of this sample to normal controls was subsequently conducted. Results: We found a higher female (73.5%) predominance; mean duration of seizures was 69.14 months. The majority of patients were single (46.13%) or divorced (16.84%), and 48% received disability benefits. A diversity of developmental risk factors as well as immediate precursors of PNES onset were identified. One year after hospitalization, significant changes were found in all seizure and healthcare characteristics of our sample. When compared to healthy volunteers, the patients also presented with a higher prevalence of stressors and traumatic events in childhood. Conclusions: Cross-cultural research contributes important information on the universal components of PNES as well as the unique features observed in distinct localities of differing cultures and ethnicities. This study allows for comparison of sociodemographic features in a Central European sample to the more frequently studied English-speaking samples.

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“…Among these individuals, TBI is also a leading cause of acquired epilepsy (Campbell et al, 2014; Wilson et al, 2017; Xu et al, 2017; Zimmermann et al, 2017). Compared to general population, individuals sustaining TBI have on average a 3-fold higher risk of developing epilepsy (Martin et al, 2014; Rehman et al, 2015; Chen et al, 2017). Epilepsy has a substantial impact on the quality of life of affected individuals, and in the United States alone, it has an estimated cost of approximately $13 billion each year (Begley and Durgin, 2015).…”

Section: Introductionmentioning

confidence: 99%

CRF Mediates Stress-Induced Pathophysiological High-Frequency Oscillations in Traumatic Brain Injury

Narla

Jung

Cruz

et al. 2019

eNeuro

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It is not known why there is increased risk to have seizures with increased anxiety and stress after traumatic brain injury (TBI). Stressors cause the release of corticotropin-releasing factor (CRF) both from the hypothalamic pituitary adrenal (HPA) axis and from CNS neurons located in the central amygdala and GABAergic interneurons. We have previously shown that CRF signaling is plastic, becoming excitatory instead of inhibitory after the kindling model of epilepsy. Here, using Sprague Dawley rats we have found that CRF signaling increased excitability after TBI. Following TBI, CRF type 1 receptor (CRFR 1 )-mediated activity caused abnormally large electrical responses in the amygdala, including fast ripples, which are considered to be epileptogenic. After TBI, we also found the ripple (120–250 Hz) and fast ripple activity (>250 Hz) was cross-frequency coupled with θ (3–8 Hz) oscillations. CRFR 1 antagonists reduced the incidence of phase coupling between ripples and fast ripples. Our observations indicate that pathophysiological signaling of the CRFR 1 increases the incidence of epileptiform activity after TBI. The use for CRFR 1 antagonist may be useful to reduce the severity and frequency of TBI associated epileptic seizures.

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Characteristics of Veterans diagnosed with seizures within Veterans Health Administration

Cited by 11 publications

References 24 publications

Risk of Epilepsy Following Traumatic Brain Injury: A Systematic Review and Meta-analysis

Risk of Epilepsy Following Traumatic Brain Injury: A Systematic Review and Meta-analysis

A descriptive study of patients diagnosed with psychogenic nonepileptic seizures at a tertiary epilepsy center in the Czech Republic: One-year follow-up

CRF Mediates Stress-Induced Pathophysiological High-Frequency Oscillations in Traumatic Brain Injury

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