Characteristics of venous‐venous extracorporeal membrane oxygenation related bloodstream infections

Wang, Joseph; Christensen, Cason; Siddique, Aleem; Merritt, H. Houston; Cawcutt, Kelly

doi:10.1111/jocs.16361

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nosocomial infections (NI) are a common complication in patients treated with ECMO [5,6]. Main sources of ECMO-related NI include bloodstream infections (BSIs), urinary tract infections (UTIs), surgical site infections (SSIs), and ventilator-associated pneumonia (VAP) [7,8]. In addition to typical ECMO-related NI, specific ECMO-related infections, such as localized infections at peripheral cannulation insertion sites or mediastinitis in the setting of central cannulation also exists [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis

Ait Hssain,

Vahedian-Azimi,

Ibrahim

et al. 2024

Crit Care

View full text Add to dashboard Cite

Background An increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-analysis aim to assess the incidence and risk factors of NIs in adult. Methods We searched PubMed, Scopus, Web of Science, and ProQuest databases up to 2022. The primary endpoint was incidence of NI. Secondary endpoints included time to infection, source of infection, ECMO duration, Intensive care and hospital length of stay (LOS), ECMO survival and overall survival. Incidence of NI was reported as pooled proportions and 95% confidence intervals (CIs), while dichotomous outcomes were presented as risk ratios (RR) as the effective index and 95% CIs using a random-effects model. Results Among the 4,733 adult patients who received ECMO support in the 30 included studies, 1,249 ECMO-related NIs per 1000 ECMO-days was observed. The pooled incidence of NIs across 18 studies involving 3424 patients was 26% (95% CI 14–38%).Ventilator-associated pneumonia (VAP) and bloodstream infections (BSI) were the most common NI sources. Infected patients had lower ECMO survival and overall survival rates compared to non-infected patients, with risk ratio values of 0.84 (95% CI 0.74–0.96, P = 0.01) and 0.80 (95% CI 0.71–0.90, P < 0.001), respectively. Conclusion Results showed that 16% and 20% lower of ECMO survival and overall survival in patients with NI than patients without NI, respectively. However, NI increased the risk of in-hospital mortality by 37% in infected patients compared with non-infected patients. In addition, this study identified the significant positive correlation between ECMO duration and ECMO-related NI.

show abstract