Background and Objectives: We evaluated the effectiveness and safety of EZ-Close TM compared to those of hand suture for trocar-site closure according to obesity. Methods: Fifty-four cases of laparoscopic colorectal surgery were enrolled. For the same patient, the right port site was closed using EZ-Close TM and left port site was closed by hand suture among cases with port-site diameter Ն10 mm. Cases switched to use of a conventional fascial closure device or with closure time 120 s were considered failures. Closure time was analyzed according to body mass index (BMI) and abdominal wall thickness (AWT). Results: The mean closure time was significantly shorter with EZ-Close TM than with hand suture (87.9 Ϯ 21.0 vs. 128.0 Ϯ 59.0 s, p Ͻ 0.001). The number of failure cases was significantly lower with EZ-Close TM than with hand suture (7 vs. 27, p Ͻ 0.001). The closure time of EZ-Close TM was significantly shorter than that of hand suture in patients with BMI Ն 25 and Ͻ 27 kg/m 2 (n ϭ 15, 85.9 Ϯ 19.8 vs. 135.6 Ϯ 67.9 s, p Ͻ 0.014) and Ն 27 kg/m 2 (n ϭ 13, 85.1 Ϯ 18.4 vs. 150.2 Ϯ 70.6 s, p Ͻ 0.010). With respect to AWT, the closure time of EZ-Close TM was significantly shorter than that of hand suture in patients with AWT Ն 20 and Ͻ 26 mm (n ϭ 12, 81.1 Ϯ 11.5 vs. 142.3 Ϯ 83.7 s, p ϭ 0.023) and Ն 26 mm (n ϭ 17, 85.6 Ϯ 22.6 vs. 160.2 Ϯ 55.5, p Ͻ 0.001). No infection and herniation were detected in both trocar sites during the follow-up period (median 20.4 months). Conclusion: EZ-Close TM could provide time efficiency in trocar-site closure, especially in obese patients.