Characteristics of Threonine, Valine and Methionine Absorption in the Jejunum and Ileum of Sheep

Wa, Phillips; Ke, Webb; Jp, Fontenot

doi:10.2527/jas1979.484926x

Cited by 12 publications

(9 citation statements)

References 90 publications

(234 reference statements)

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“…These amino acids were not absorbed from the duodenum. They later confirmed, using perfused intestinal segments of sheep, that the ileum is the dominant site of amino acid absorption (Phillips et al, 1979). Wilson and Webb (1990) reported that total methionine and lysine uptake was higher by ileal brush border membrane vesicles than by jejunal brush border membrane vesicles.…”

Section: Amino Acid Absorptionmentioning

confidence: 85%

“…In situ procedures have been utilized in which absorption has been studied using ligated intestinal segments of the rat (Gibson and Wiseman, 1951) and sheep (Williams, 1969). Perfusion of the intestine of rats (Jacobs and Lang, 1965) or intestinal segments of sheep (Phillips et al, 1979) also has provided useful information. Tubes with double or triple lumens that are passed through the nasal cavity, down the esophagus, through the stomach and into the small intestine have been especially useful in measuring amino acid absorption in the intact intestine of the human (Cummins, 1952;FleshIer et al, 1966;.…”

Section: Amino Acid Absorptionmentioning

confidence: 99%

“…More methionine was absorbed than either threonine or valine from everted sacs of ovine intestine (%Kips et al, 1976) and, when different mixtures of methionine. valine and threonine were perfused through isolated segments (Phillips et al, 1979), methionine was absorbed in the greatest amounts and was a strong inhibitor of the absorption of both valine and threonine. AU the interactions that are observed among amino acids in the absorptive process are not negative.…”

Section: The Relative Importance Of Na+dependentmentioning

confidence: 99%

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Intestinal absorption of protein hydrolysis products: a review.

Webb

1990

Journal of Animal Science

161

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Many experimental techniques have allowed researchers to probe the fate of hydrolysis products from proteins in the small intestine. An overview of amino acid and peptide absorption from the small intestine is presented with attention given to historical perspectives that have led to current concepts. Speculation about nutritional significance of these processes is offered. Species differences exist in site of amino acid absorption. Numerous mechanisms are available for the transport of amino acids, including Na(+)-dependent carriers (energy-requiring), Na(+)-independent carriers and diffusion. The relative contribution each transport system makes to absorption is dependent on substrate concentration. Individual amino acids are not absorbed with equal efficiency; methionine usually is absorbed in the greatest proportion. There are interactions among amino acids for transports by specific transport systems. Small peptides (mostly di- and tripeptides) are absorbed from the small intestine more rapidly than are free amino acids; peptides are transported by systems independent of those responsible for transporting free amino acids. Evidence exists that the active transport of these peptides is via a proton gradient. Although the concept that peptides are absorbed intact into the circulation is not universally accepted, evidence supporting the possibility of tissue utilization of these small peptides is accumulating.

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Section: Amino Acid Absorptionmentioning

confidence: 85%

Section: Amino Acid Absorptionmentioning

confidence: 99%

Section: The Relative Importance Of Na+dependentmentioning

confidence: 99%

See 1 more Smart Citation

Intestinal absorption of protein hydrolysis products: a review.

Webb

1990

Journal of Animal Science

161

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“…The differences among species may reflect the site of protein digestion and the availability of peptide substrates. The major site of amino acid absorption is recognized to be the jejunum in laboratory species such as the rat (Baker and George, 1971) and the ileum in sheep (Phillips et al, 1976(Phillips et al, , 1979 and cattle (Wilson and Webb, 1990). …”

Section: Discussionmentioning

confidence: 99%

Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens.

Chen

Wong

Webb

1999

Journal of Animal Science

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“…The depression in gain of steers fed the two highest levels of RPMet and RPLys may have been due to inhibitory effects of methionine and(or) lysine on absorption of other amino acids. Reiser and Christiansen (1969) observed competition for carrier mediated enzyme binding sites between neutral and basic amino acids, and Phillips et al (1979) reported that methionine consistently inhibited valine and threonine absorption in sheep.…”

Section: Steer Plasma Amino Acid Response Trialmentioning

confidence: 99%

Effects of Rumen-Protected Amino Acids on Ruminant Nitrogen Balance, Plasma Amino Acid Concentrations and Performance

Wright

Loerch

1988

Journal of Animal Science

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A series of trials was conducted to determine the effects of supplemental rumen-protected methionine (RPMet) and lysine (RPLys) on nutrient metabolism and performance. In situ RPMet N disappearance was less than 4% following 48 h of incubation and was not affected (P greater than .05) by diet or resultant ruminal pH differences, indicating that RPMet was well protected from ruminal microbial degradation. Thirty-five Dorset-sired crossbred wether lambs (avg wt 28 kg) fed ground corn-soybean hull diets supplemented with urea were randomly assigned to one of the following treatments: 1) 0% RPMet, 2) .03% RPMet, 3) .06% RPMet, 4) .09% RPMet or 5) .12% RPMet. Dry matter, fiber and N digestibilities and N retention were not affected (P greater than .05) by treatment. Plasma methionine concentration tended to increase linearly (P less than .07) with dietary RPMet level. Six Simmental X Angus steers (avg wt 427 kg) were fed a corn grain-corn silage diet supplemented with urea and five levels of RPMet: 1) 0%, 2) .04%, 3) .08%, 4) .12% and 5) .16%. The plasma methionine concentration increased linearly (P less than .01) with dietary RPMet level. In a steer performance trial, no improvements in feedlot performance resulted due to these RPMet levels (P greater than .05), suggesting that the control diet (0% RPMet) was meeting the methionine requirement of these steers. The effects of RPMet and RPLys on growing and finishing steer feedlot performance also were evaluated. Treatments were 1) urea control, 2) soybean meal positive control, 3) .09% RPMet + .06% RPLys, 4) .12% RPMet + .08% RPLys and 5) .15% RPMet + .10% RPLys. In the growing trial, added RPMet and RPLys did not improve steer feedlot performance. In the finishing trial, only steers fed .09% RPMet + .06% RPLys had higher (P less than .05) gains than those fed the urea control diet. These trials indicate that postruminal methionine and lysine supplies were not limiting feedlot steer performance.

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Characteristics of Threonine, Valine and Methionine Absorption in the Jejunum and Ileum of Sheep

Cited by 12 publications

References 90 publications

Intestinal absorption of protein hydrolysis products: a review.

Intestinal absorption of protein hydrolysis products: a review.

Tissue distribution of a peptide transporter mRNA in sheep, dairy cows, pigs, and chickens.

Effects of Rumen-Protected Amino Acids on Ruminant Nitrogen Balance, Plasma Amino Acid Concentrations and Performance

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