Characteristics of the inner retinal layer in the fellow eyes of patients with unilateral exudative age-related macular degeneration

Abstract

Objective To investigate the thicknesses of the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) of the fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD). Methods A total of 107 patients with unilateral exudative AMD [34 of typical choroidal neovascularization (tCNV), Group A; 73 of polypoidal choroidal vasculopathy (PCV), Group B] and 73 normal control eyes (Group C) were included. Drusen and subretinal drusenoid deposits were assessed in all participants using fundus photography, autofluorescence, and optical coherence tomography (OCT). The GC-IPL and RNFL thicknesses were measured using Cirrus HD-OCT and compared among groups. Linear regression analyses were used to evaluate the factors associated with GC-IPL thicknesses. Results The average GC-IPL thicknesses of Groups A, B, and C were 77.09 ± 3.87, 80.10 ± 6.61, and 80.88 ± 6.50 μm, respectively (p = 0.022). Sectoral GC-IPLs and central macular thicknesses (CMTs) were significantly different among groups (all, p <0.05), whereas none of the RNFL parameters differed significantly (all, p >0.05). Multivariate linear regression analyses revealed that age (p <0.001), CMT (p <0.001), and tCNV (p = 0.013) were significantly associated with average GC-IPL thickness, and the rate of reduction of GC-IPL thickness with increasing age in the fellow eyes of tCNV patients was higher than those in the PCV and control groups.

Chronic Central Serous Chorioretinopathy in Elderly Subjects: Structure and Blood Flow Characteristics of Retina and Choroid

“…The incidence of SDD in our cohort is very low and only found in the elderly group. It is reported that the incidence of SDD in PCV is 4.1%, which is considered as an independent risk factor for neovascularization [ 40 ], while the incidence of pachydrusen in PCV is 70% [ 41 ]. We believe that elderly cCSC patients with hyaline warts are more likely to develop PCV.…”

Inner Retinal Layer Thickness Alterations in Early Age Related Macular Degeneration in Eyes with Subretinal Drusenoid Deposits or Conventional Drusen

“…Thinning of the inner retinal structures has been reported for the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), and ganglion cell complex (GCC) [ 9 , 10 , 11 , 12 ]. Suggested pathogenetic theories for inner retinal involvement are microvascular alterations with inner retinal ischemia and post-receptor trans-synaptic degeneration [ 1 , 6 , 7 , 11 , 13 , 14 ]. SDD are associated with both forms of late AMD, geographic atrophy and neovascularization [ 15 ].…”