2011
DOI: 10.1371/journal.ppat.1001251
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Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1

Abstract: Recent cross-sectional analyses of HIV-1+ plasmas have indicated that broadly cross-reactive neutralizing antibody responses are developed by 10%–30% of HIV-1+ subjects. The timing of the initial development of such anti-viral responses is unknown. It is also unknown whether the emergence of these responses coincides with the appearance of antibody specificities to a single or multiple regions of the viral envelope glycoprotein (Env). Here we analyzed the cross-neutralizing antibody responses in longitudinal p… Show more

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Cited by 281 publications
(339 citation statements)
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“…Acutely HIV‐1‐infected individuals do not make bnAbs,41, 43 but during chronic HIV‐1 infection, neutralization breadth develops to a greater or lesser degree in each person 45, 46, 47. Breadth of plasma neutralizing activity develops incrementally,48 and evidence suggests that protracted exposure to HIV‐1 Env is required 22, 23, 24, 47, 48, 49, 50.…”
Section: Development Of Broadly Neutralizing Antibodies In Hiv‐1 Infementioning
confidence: 99%
“…Acutely HIV‐1‐infected individuals do not make bnAbs,41, 43 but during chronic HIV‐1 infection, neutralization breadth develops to a greater or lesser degree in each person 45, 46, 47. Breadth of plasma neutralizing activity develops incrementally,48 and evidence suggests that protracted exposure to HIV‐1 Env is required 22, 23, 24, 47, 48, 49, 50.…”
Section: Development Of Broadly Neutralizing Antibodies In Hiv‐1 Infementioning
confidence: 99%
“…Although strain-specific Abs are more common, a subset of HIV-infected individuals develops broadly neutralizing Abs (bNAbs), i.e., Abs that neutralize many viral strains, and this happens only several years after infection (10,11). Until recently, very few (e.g., 4E10, 2F5, 2G12, and b12) monoclonal human Abs with broadly neutralizing activity had been isolated (12)(13)(14)(15).…”
mentioning
confidence: 99%
“…In addition, high viral loads and coevolution of viral quasispecies have been implicated in the development of serologic breadth, suggesting that constant immune activation and antigen recognition may play a key role in HIV antibody maturation processes. However, while immune activation and lack of controlled HIV viremia appear to be favorable for bNAb elicitation, increased frequencies of peripheral CD4 T cells expressing combinations of functional markers present on germinal center (GC) T follicular helper (Tfh) cells have also been associated with the development of bNAbs and B cell memory phenotypes (6)(7)(8). It is well known that Tfh cells play a crucial role in the development of long-lived, high-affinity antibody responses during the germinal center reaction (9).…”
mentioning
confidence: 99%