Characteristics of the Computed Tomography Imaging Findings in 72 Patients with Airway-Invasive Pulmonary Aspergillosis

Wu, Jing; Zhang, Tao; Pan, Junping; Zhang, Qian; Lin, Xin; Chang, Ligong; Chen, Yu‐Chen; Xue, Xinying

doi:10.12659/msm.931162

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…По мере прогрессирования заболевания множественные центрилобулярные очаги сливаются между собой и формируют участки консоли-дации, чаще в субплевральных отделах. На их фоне в динамике могут сформироваться полости распада [32].…”

Section: кт-симптомы аспергиллеза легких до пандемии Covid-19unclassified

Possibilities of CT in the diagnosis of pulmonary aspergillosis in patients with COVID-19 (literature review)

Nay,

Yudin,

Abovich

2023

Medicinskaâ vizualizaciâ

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Aim: to analyze the latest research in the field of CT diagnostics of pulmonary aspergillosis in patients with COVID-19 according to domestic and foreign literature.Results. Pulmonary aspergillosis is one of the most common life-threatening fungal diseases that is caused by inhalation of Aspergillus mold spores and affects all parts of the respiratory system. In recent years, there has been a sharp increase in cases of invasive mycotic processes. During the COVID-19 pandemic, according to a number of authors, the incidence of pulmonary aspergillosis reached 34.4%, and the mortality rate was 74%. The World Health Organization calls for “minimizing the disproportionate use of corticosteroids and antibiotics for mild and moderate cases”. She explained that corticosteroids in severe cases do save lives, but their massive use can cause fungal infections. This complication is increasingly common in patients after corticosteroid and antibiotic therapy, with immunodeficiency states, as well as those treated in intensive care units. The COVID-19 pandemic has created additional challenges in the diagnosis, treatment and prevention of fungal complications. The clinical and radiographic features of fungal infections are largely similar to typical pulmonary manifestations of COVID-19. A comparative analysis of CT signs of various forms of pulmonary aspergillosis before and during the COVID-19 pandemic was carried out according to the literature. The main CT symptoms of mycotic lung lesions among patients who have undergone COVID-19 have been identified. Currently, computed tomography is crucial, first of all, to detect and monitor complications of COVID-19, including the addition of a secondary fungal infection.Conclusion. To make a conclusion about mycosis in the early stages, special vigilance and high qualification of the radiologist are required, which in turn will contribute to the timely appointment of antifungal therapy, which will reduce morbidity and mortality.

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Section: кт-симптомы аспергиллеза легких до пандемии Covid-19unclassified

Possibilities of CT in the diagnosis of pulmonary aspergillosis in patients with COVID-19 (literature review)

Nay,

Yudin,

Abovich

2023

Medicinskaâ vizualizaciâ

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Use of CT-derived radiomic features to preoperatively identify invasive mucinous adenocarcinoma in solitary pulmonary nodules ≤3 cm

Xiao,

Chen,

Feng

et al. 2024

Heliyon

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Distribution of Aspergillus species and risk factors for aspergillosis in mainland China: a systematic review

Khan,

Bilal,

Shafiq

et al. 2024

Therapeutic Advances in Infection

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Background: Aspergillus, a widespread fungus in the natural environment, poses a significant threat to human health by entering the human body via the airways and causing a disease called aspergillosis. This study comprehensively analyzed data on aspergillosis in published articles from mainland China to investigate the prevalence of Aspergillus, and risk factors, mortality rate, and underlying condition associated with aspergillosis. Methods: Published articles were retrieved from Google Scholar, PubMed, and Science Direct online search engines. In the 101 analyzed studies, 3558 Aspergillus isolates were meticulously collected and classified. GraphPad Prism 8 was used to statistically examine the epidemiology and clinical characteristics of aspergillosis. Results: Aspergillus fumigatus was prominently reported ( n = 2679, 75.14%), followed by A. flavus ( n = 437, 12.25%), A. niger ( n = 219, 6.14%), and A. terreus ( n = 119, 3.33%). Of a total of 9810 patients, 7513 probable cases accounted for the highest number, followed by confirmed cases ( n = 1956) and possible cases ( n = 341). In patients, cough emerged as the most common complaint ( n = 1819, 18.54%), followed by asthma ( n = 1029, 10.48%) and fever (1024, 10.44%). Of total studies, invasive pulmonary aspergillosis (IPA) was reported in 47 (45.53%) studies, exhibiting an increased prevalence in Beijing ( n = 12, 25.53%), Guangdong ( n = 7, 14.89%), and Shanghai ( n = 6, 12.76%). Chronic pulmonary aspergillosis (CPA) was reported in 14 (13.86%) studies. Among the total of 14 studies, the occurrence of CPA was 5 (35.71%) in Beijing and 3 (21.42%) in Shanghai. Allergic bronchopulmonary aspergillosis (ABPA), was reported at a lower frequency ( n = 8, 7.92%), Guangdong recorded a relatively high number ( n = 3, 37.5%), followed by Beijing ( n = 2, 25.0%), and Shanghai ( n = 1, 12.5%). Percentage of death reported: IPA had the highest rate ( n = 447, 68.87%), followed by CPA ( n = 181, 27.88%) and ABPA ( n = 14, 2.15%). Among the aspergillosis patients, 6220 had underlying conditions, including chronic lung disease ( n = 3765, 60.53%), previous tuberculosis ( n = 416, 6.68%), and organ transplant or organ failure ( n = 648, 10.41%). Aspergillosis was also found in patients using corticosteroid therapy ( n = 622, 10.0%). Conclusion: This review sheds light on the prevalence patterns of Aspergillus species, risk factors of aspergillosis, and gaps in surveillance that could be helpful for the control and treatment of aspergillosis and guide the researchers in future studies. Registration: This systematic review was prospectively registered on PROSPERO: Registration ID CRD42023476870.

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Characteristics of the Computed Tomography Imaging Findings in 72 Patients with Airway-Invasive Pulmonary Aspergillosis

Cited by 3 publications

References 32 publications

Possibilities of CT in the diagnosis of pulmonary aspergillosis in patients with COVID-19 (literature review)

Possibilities of CT in the diagnosis of pulmonary aspergillosis in patients with COVID-19 (literature review)

Use of CT-derived radiomic features to preoperatively identify invasive mucinous adenocarcinoma in solitary pulmonary nodules ≤3 cm

Distribution of Aspergillus species and risk factors for aspergillosis in mainland China: a systematic review

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