Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients

Xu, Jiadai; He, Xiaofei; Xu, Yunqi; Chen, Xi; Li, Mingyue; Zhang, Liying; Fu, Xiaodi; Pan, Mengqiu; Wang, Qun; Hu, Xiquan

doi:10.1002/acn3.51512

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…IL‐1β levels in the CSF were positively correlated with brain iron deposition detected by susceptibility weighted image (SWI) (Liu et al, 2017). In addition, there was an association between serum IL‐1β concentrations and iron deposition measured by quantitative susceptibility mapping (QSM) (Xu et al, 2022). What is more, it has been reported from animal studies that microglial activation is associated with increased ferritin expression and iron deposition in the SN (Hunter et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Clinical findings of hyperechoic substantia nigra in patients with Parkinson's disease

Fan,

Ma,

Yang

et al. 2024

Eur J of Neuroscience

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This study aims to analyse hyperechoic substantia nigra (HSN) characteristics and the correlation of HSN with clinical features and blood biomarkers in patients with Parkinson's disease (PD). Transcranial sonography (TCS) evaluations of the substantia nigra (SN) were performed in 40 healthy controls and 71 patients with PD, including patients with SN hyperechogenicity (SN+) and those with normal SN echogenicity (SN−). Evaluation of motor and non‐motor symptoms was assessed by a series of rating scales. The uricase method was used to determine serum uric acid (UA) levels, and enzyme‐linked immunosorbent assay (ELISA) was used to measure plasma interleukin (IL)‐1β levels. TCS showed 92.50% specificity and 61.97% sensitivity in differentiating PD patients from controls. The area of SN+ contralateral to the side of initial motor symptoms (SNcontra) was larger than that ipsilateral to the side of initial motor symptoms (SNipsi). The PDSN+ group had lower Argentine Hyposmia Rating Scale (AHRS) scores and UA levels than the PDSN− group. Binary logistic regression analysis revealed that AHRS scores and UA levels could be independent predictors for HSN. The larger SN echogenic area (SNL) sizes positively correlated with plasma IL‐1β levels in PD patients with SN+. The present study provides further evidence of the potential of SN echogenicity as an imaging biomarker for PD diagnosis. PD patients with HSN have more severe non‐motor symptoms of hyposmia. HSN in PD patients is related to the mechanism of abnormal iron metabolism and microglial activation.

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Section: Discussionmentioning

confidence: 99%

Clinical findings of hyperechoic substantia nigra in patients with Parkinson's disease

Fan,

Ma,

Yang

et al. 2024

Eur J of Neuroscience

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“…Several studies have found elevated concentrations of IL-33 in serum and midbrain and striatum in PD groups, and IL-33 enhances glial maturation factor (GMF)-mediated neuroinflammation [ 134 , 135 ]. In addition, Xu et al found that serum IL33 concentrations were higher in early PD patients than in late [ 136 ].…”

Section: Discussionmentioning

confidence: 99%

Study of molecular patterns associated with ferroptosis in Parkinson’s disease and its immune signature

Chen,

Xin,

et al. 2023

PLoS ONE

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Parkinson’s disease is the second most common neurodegenerative disease in the world. We downloaded data on Parkinson’s disease and Ferroptosis-related genes from the GEO and FerrDb databases. We used WCGAN and Random Forest algorithm to screen out five Parkinson’s disease ferroptosis-related hub genes. Two genes were identified for the first time as possibly playing a role in Braak staging progression. Unsupervised clustering analysis based on hub genes yielded ferroptosis isoforms, and immune infiltration analysis indicated that these isoforms are associated with immune cells and may represent different immune patterns. FRHGs scores were obtained to quantify the level of ferroptosis modifications in each individual. In addition, differences in interleukin expression were found between the two ferroptosis subtypes. The biological functions involved in the hub gene are analyzed. The ceRNA regulatory network of hub genes was mapped. The disease classification diagnosis model and risk prediction model were also constructed by applying hub genes based on logistic regression. Multiple external datasets validated the hub gene and classification diagnostic model with some accuracy. This study explored hub genes associated with ferroptosis in Parkinson’s disease and their molecular patterns and immune signatures to provide new ideas for finding new targets for intervention and predictive biomarkers.

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“…Iron is one of the common biological essential trace elements, which plays many critical cellular functions in all organisms while catalyzing the formation of potentially toxic free radicals. A large body of evidence substantiates the potential additive effect of oxidative stress as iron stores increase, further exacerbating disease susceptibility and responses to infection and inflammation ( 46 , 47 ). The observed increase in iron concentration with C-DII in our study suggests that an inflammatory diet may lead to inflammatory oxidative stress in the body (especially the liver).…”

Section: Discussionmentioning

confidence: 99%

Association Between the Children's Dietary Inflammatory Index (C-DII) and Markers of Inflammation and Oxidative Stress Among Children and Adolescents: NHANES 2015-2018

Zhang

Ren

et al. 2022

Front. Nutr.

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ObjectivesTo explore the association of Children's Dietary Inflammatory Index (C-DII) scores with inflammation and markers of inflammatory factors in children and adolescents.MethodsData on dietary nutrient intake, markers of inflammation (ferritin, alkaline phosphatase, C-reactive protein (CRP), absolute neutrophil cell count and lymphocyte count) and oxidative stress (serum bilirubin, albumin, and iron) were available for participants aged 6–19 years (n = 1281). Each participant's C-DII score was calculated based on a 24-h diet and recall. Generalized linear models were applied to examine associations between C-DII and markers of inflammation and oxidative stress, while adjusting for covariates. Restricted cubic splines were used to explore the dose-response association of C-DII scores with indicators of inflammatory oxidative stress. Akaike's Information Criterionwas applied to compare the performance of linear and non-linear models.ResultsAfter adjusting for potential confounders, quantile regression results showed that when comparing C-DII quartile 4 (most pro-inflammatory) and quartile 1 (most anti-inflammatory), lymphocytes, ferritin, CRP were statistically significant differences in serum bilirubin, albumin and serum iron (P < 0.05). The C-DII score showed a non-linear relationship with inflammatory oxidative stress indicators. Overweight/obese children and adolescents who ate a high pro-inflammatory diet were more likely to have higher levels of inflammatory cytokines (P = 0.002).ConclusionsThe dietary inflammatory index in children is associated with markers of chronic inflammation and oxidative stress. A pro-inflammatory diet resulted in increased serum concentrations of these markers, implying that early dietary interventions have implications for reducing chronic inflammation and oxidative stress in children and adolescents.

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Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients

Abstract: measurement, the Home for Researchers editorial team for the language polishment (www.home-for-researchers.com).

Cited by 11 publications

References 33 publications

Clinical findings of hyperechoic substantia nigra in patients with Parkinson's disease

Clinical findings of hyperechoic substantia nigra in patients with Parkinson's disease

Study of molecular patterns associated with ferroptosis in Parkinson’s disease and its immune signature

Association Between the Children's Dietary Inflammatory Index (C-DII) and Markers of Inflammation and Oxidative Stress Among Children and Adolescents: NHANES 2015-2018

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