Characteristics of stimulation of gonadotropin secretion by kisspeptin-10 in female goats

Interactions between prolactin and kisspeptin to control reproduction

“…Administration of kisspeptin-10 to culture media prepared with anterior pituitary cells extracted from 8-month-old castrated male calves increased prolactin secretion (49). However, several other studies were unable to demonstrate such effect (Table 1) (50)(51)(52)(53). In humans, for example, acute or a week of twice-daily subcutaneous (sc) administrations of kisspeptin-54, at a dose known to stimulate gonadotropin secretion, induced no effect on serum prolactin levels in healthy women (53).…”

International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin Receptor Nomenclature, Distribution, and Function

“…Kisspeptin is able to stimulate gonadotropin release in humans (Dhillo et al, 2005(Dhillo et al, , 2007, mice Messager et al, 2005b), rats (Navarro et al, 2004a(Navarro et al, , 2005aThompson et al, 2004Thompson et al, , 2006, monkeys Seminara, 2006), and sheep (Messager et al, 2005b;Caraty et al, 2007). GnRH is a direct mediator of this effect, as shown in monkeys (Keen et al, 2008), sheep (Messager et al, 2005b), pigs (Lents et al, 2008), and goats (Hashizume et al, 2010). GnRH antagonists are able to block kisspeptin-induced release of gonadotropins Matsui et al, 2004;Navarro et al, 2004a).…”

Characteristics of the Stimulatory Effect of Kisspeptin-10 on the Secretion of Luteinizing Hormone, Follicle-Stimulating Hormone and Growth Hormone in Prepubertal Male and Female Cattle

“…An administration of kisspeptin, either centrally or peripherally, has been shown to elicit the release of gonadotropins in ruminants [10][11][12][13][14][15] as well as in rats [16,17], pigs [18], monkeys [19] and humans [20,21]. However, in cattle, only two in vivo studies have been conducted [13,14], and the precise effects of kisspeptin on the secretion of pituitary hormones under physiological conditions are unknown.…”

“…Kisspeptin neurons are found in the hypothalamus [7][8][9], and kisspeptins strongly stimulate the secretion of gonadotropin through a G protein-coupled receptor known as GPR54 [3][4][5]. The actions of these peptides are thought to involve mainly stimulating GnRH's neuronal activity through GPR54 [3][4][5].An administration of kisspeptin, either centrally or peripherally, has been shown to elicit the release of gonadotropins in ruminants [10][11][12][13][14][15] as well as in rats [16,17], pigs [18], monkeys [19] and humans [20,21]. However, in cattle, only two in vivo studies have been conducted [13,14], and the precise effects of kisspeptin on the secretion of pituitary hormones under physiological conditions are unknown.…”

“…: 3.85 nmol/kg b.w.) or 2 ml of saline as a control.The doses of Kp10 were chosen according to results of preliminary experiments [15]. The animals were used repeatedly for each treatment, and the experiments were carried out at 2-or 3-day intervals.…”