Characteristics of response of oral and pharyngeal mucosa in patients receiving chemo-IMRT for head and neck cancer using hypofractionated accelerated radiotherapy

Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose–volume analysis

“…The definition of total oral mucosa, including the upper digestive tract, derives from a previous analysis in which a dose of 9.5 to 10 Gy/week in more than 50 to 60 cm was considered as a predictor of percutaneous endoscopic gastrostomy insertion during intensity-modulated radiation therapy treatment. 28 In a study by Bhide et al, 19 it was shown that there was a significant correlation between the length of the pharyngeal mucosa treated to 50 Gy and 60 Gy and the incidence of grade 3 dysphagia. For the authors, observer-assessed acute swallowing symptoms (such as burning, dysphagia, and pain) were a surrogate of pharyngeal mucositis extension.…”

“…In a study by Bhide et al, it was shown that there was a significant correlation between the length of the pharyngeal mucosa treated to 50 Gy and 60 Gy and the incidence of grade 3 dysphagia. For the authors, observer‐assessed acute swallowing symptoms (such as burning, dysphagia, and pain) were a surrogate of pharyngeal mucositis extension.…”

Helical tomotherapy: an innovative radiotherapy technique for the treatment of locally advanced oropharynx and inoperable oral cavity carcinoma

“…Bhide et al [18] compared the response of oral and pharyngeal mucosa in patients receiving concomitant chemoradiotherapy with IMRT technique for head and neck cancer, using hypofractionated accelerated schemes of 2.17 Gy, 2.25 Gy and 2.4 Gy per fraction. Grade 3 dysphagia was correlated with the length of pharyngeal mucosa receiving doses close to the prescription dose; its incidence was lower and patients recovered earlier in case of greater overall treatment time.…”

Evaluation of radiotherapy techniques for radical treatment of lateralised oropharyngeal cancers

“…The probability of neurocognitive function (NCF) impairment was evaluated using the NTCP model described by Gondi et al [15], where the probability of a decline in short-term memory function, as measured by the Wechsler Memory Scale-III Word Lists as delayed recall at 18 months post-RT, is related to the bilateral hip-K pocampal EQD2 D40. The NTCPs of grade 3 dysphagia and grade 3 oral mucositis were predicted according to the models derived by Bhide et al [17].…”