Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment

Li, Ping; Ghadersohi, Saied; Jafari, Behrouz; Teter, Barbara; Sazgar, Mona

doi:10.1016/j.seizure.2012.07.016

Cited by 33 publications

(24 citation statements)

References 42 publications

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“…Previous studies have also demonstrated that an improvement in seizure frequency in refractory epileptic patients is achieved with the treatment of OSAS [26,27]. The screening for SBD to recognize an altered nocturnal respiratory function in the medically refractory epilepsy population is particularly outstanding to set up early intervention strategies [28,29].…”

Section: Discussionmentioning

confidence: 99%

Sleep Abnormalities and Sleep Breathing Disorders in Children with Drug- Resistant Catastrophic Epileptic Encephalopathy

Gaeta¹

2015

J Sleep Disord Ther

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Undiagnosed obstructive sleep apnoea is common in patients with medically refractory epilepsy. The aim of this study is to evaluate sleep alterations and the prevalence of Sleep Breathing Disorders (SBD) in a paediatric population with catastrophic epileptic encephalopathy. To diagnose SBD, polysomnography (PSG) was performed in eleven patients (nine males, two females), with ages ranging between 3 and 11 years old, with epileptic encephalopathy characterized by drug-resistant seizures, occurring both in sleeping and waking, mental retardation and cerebral palsy. All the patients presented alterations of the sleep architecture and were positive for SBD. In particular, seven patients presented a severe form of Obstructive Sleep Apnoea Syndrome (OSAS) with apnoea/ hypopnea index (AHI) greater than10/hr, two patients presented a moderate form with AHI between 5/hr and 10/hr, two patients presented a mild form with AHI lower than 4/hr. In conclusion, SBD and sleep disruption appeared to be in comorbidity with catastrophic epileptic encephalopathy. Their treatment might also have a positive impact in seizures control and quality of life.

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Section: Discussionmentioning

confidence: 99%

Sleep Abnormalities and Sleep Breathing Disorders in Children with Drug- Resistant Catastrophic Epileptic Encephalopathy

Gaeta¹

2015

J Sleep Disord Ther

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“…Among the common population, the incidence rate of sleep apnea is at least 3%, while polysomnography analysis of investigated epileptic patients revealed that the incidence rate of sleep apnea may be up to 70%. For epileptic patients, seizures may improve following the diagnosis and treatment of sleep apnea (9). Although Li et al (9) did not evaluate the correlation of apnea with epileptic seizures, decreased oxygen saturation may cause brain stimulation or chronic sleep deprivation, aggravating the epileptic seizures.…”

Section: Discussionmentioning

confidence: 99%

“…For epileptic patients, seizures may improve following the diagnosis and treatment of sleep apnea (9). Although Li et al (9) did not evaluate the correlation of apnea with epileptic seizures, decreased oxygen saturation may cause brain stimulation or chronic sleep deprivation, aggravating the epileptic seizures. VPA is known to cause weight gain, which in turn is capable of aggravating sleep apnea.…”

Section: Discussionmentioning

confidence: 99%

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Effect of sodium valproate on the sleep structures of epileptic patients

Zhang

et al. 2014

Experimental and Therapeutic Medicine

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The aims of the present study were to investigate the effect of sodium valproate (VPA) on the sleep structures of epileptic patients and the correlation of these effects with patient weight gain. A total of 60 epileptic patients were divided into three groups: E-AED I (VPA administration for a duration of <3 months), E-AED II (VPA administration for a duration of >3 months) and ECO (without VPA) groups, for polysomnography monitoring. When the E-AED II group was compared with the E-AED I and ECO groups, non-rapid eye movement sleep phase 1 was significantly prolonged (92.10±48.24, 29.50±10.61 and 23.94±13.27 min, respectively; P<0.01), rapid eye movement sleep was significantly shortened (70.82±17.69, 116.99±12.90 and 126.19±35.01 min, respectively; P<0.01), sleep efficiency was significantly reduced (89.39±2.55, 91.98±2.53 and 91.96±3.14%, respectively; P<0.01), the number of times of that the patients awoke was significantly increased (7.25±2.86, 2.55±1.42 and 2.40±1.39, respectively; P<0.01) and the number of REM phases throughout the night was significantly reduced (P<0.01). There were no significant differences for the various sleep parameters between the E-AED I and ECO groups. Therefore, VPA is capable of inducing sleep structure disorders in epileptic patients. In addition, these disorders begin 3 months following the administration of VPA, which indicates that these disorders may be associated with VPA-induced weight gain.

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“…149 A double-blind, placebo-controlled crossover study showed pregabalin increased NREM 3, decreased NREM 1 sleep, and improved attention in 9 adults with well-controlled epilepsy and sleep-maintenance insomnia. 150 …”

Section: Pregabalin and Gabapentin May Improve Disturbed Sleep In Peomentioning

confidence: 99%

Primary Sleep Disorders in People with Epilepsy

Grigg-Damberger

Foldvary‐Schaefer

2015

Child and Adolescent Psychiatric Clinics of North America

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Characteristics of refractory vs. medically controlled epilepsy patients with obstructive sleep apnea and their response to CPAP treatment

Abstract: This study confirms that OSA is common in epilepsy patients and treatment of OSA can improve seizure control in medically refractory cases. Patients with refractory epilepsy who have diabetes are more likely to have OSA.

Cited by 33 publications

References 42 publications

Sleep Abnormalities and Sleep Breathing Disorders in Children with Drug- Resistant Catastrophic Epileptic Encephalopathy

Sleep Abnormalities and Sleep Breathing Disorders in Children with Drug- Resistant Catastrophic Epileptic Encephalopathy

Effect of sodium valproate on the sleep structures of epileptic patients

Primary Sleep Disorders in People with Epilepsy

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