Characteristics of qacA/B-positive Staphylococcus aureus isolated from patients and a hospital environment in China

Lu, Zhongyi; Chen, Yong; Chen, Wei; Liu, Hui; Song, Qing; Hu, Xin; Zou, Ziying; Liu, Zhengxiang; Duo, Libo; Yang, Jiyong; Gong, Yanwen; Wang, Zhanke; Xu-qin, WU; Zhao, Jingya; Zhang, Changjian; Zhang, Mengqiang; Han, Li

doi:10.1093/jac/dku456

Cited by 26 publications

(24 citation statements)

References 19 publications

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“…[21][22][23] For patients where Pseudomonas aeruginosa (2 patients), Streptococcus parasanguinis (2 patients) and Aeromonas hydrophila/caviae (1 patient), 100% resistance to chlorhexidine was oberved (Figure 1) and is in line with other studies. 18,24 This is also supported by a study that proved the low susceptibility of Pseudomonas stutzeri.…”

Section: Pathogen (N) Antibiotic Resistant Cases (N)supporting

confidence: 88%

“…Chlorhexidine seems to be the most widely used oral disinfectant 8 and, as a result, more and more evidence of resistance to chlorhexidine is emerging. [17][18][19][20][21][22][23] In 2002, one research study indicated that strains of microorganisms resistant to antibiotics were also less susceptible to chlorhexidine. 24 The number of antimicrobial Table 3.…”

Section: Discussionmentioning

confidence: 99%

“…21 One study found that the efficacy of chlorhexidine was weak in comparison to other disinfectants against five pathogens.…”

Section: Pathogen (N) Antibiotic Resistant Cases (N)mentioning

confidence: 99%

“…16 However, other research projects have found that the effectiveness of chlorhexidine against K. pneumonia is greatly reduced. [17][18][19][20] A study in a hospital environment in China observed that isolates of S. aureus showed reduced susceptibility to chlorhexidine 21 and was confirmed in Taiwan. 22 It was also stated that the "reduced microbial susceptibility to biocides represents a serious cause for concern in the clinical environment".…”

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confidence: 99%

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A Descriptive Study of Chlorhexidine as a Disinfectant in Cleft Palate Surgery

Roode¹,

Bütow²

2018

Clin Med Res

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Objectives:Chlorhexidine is seen as the golden standard of disinfectants. It is widely used to clean surgical sites; however, many studies indicate resistance of pathogens to chlorhexidine. One study indicated that pathogenic microorganisms were isolated from the soft palate cleft region in 57% of patients with facial clefts. The objectives of our study were to determine (1) if chlorhexidine application is effective in removing pathogens from the surgical site in these patients, and (2) if any pathogens are isolated, determine if they are resistant to other antimicrobials. Design:A descriptive observational study. Settings:A private practice that specializes in facial cleft surgery, with a country-wide patient base. All procedures were executed by one oral and maxillofacial surgeon.Participants: All patients (N=50) who presented for primary repair of the soft palate cleft were included in the study. Inclusion criteria: written consent from parent(s), and patient cleared as systemically healthy by a pediatric physician. Exclusion criteria: patient(s) with systemic infections (eg, flu) and/or any local infections (eg, tonsillitis). There were 25 males and 25 females with an average age of 7 months and 16 days included in the study.Methods: Swabs were taken from the surgical site of all 50 patients with cleft soft palate and were sent for culture, identification and antimicrobial sensitivity. The swabs were taken before disinfecting the site as well as after 2 minutes of disinfecting the surgical site with chlorhexidine. Results were compared against each other.Results: Positive cultures with 28 different pathogenic microorganisms that were identified in 47 patients before cleaning the surgical site with the chlorhexidine. The most dominant pathogens were K. pneumonia (n=22), H. influenza (n=18) and S. aureus (n=10). Of the pathogens found, 13 (46%) were still present on the swabs taken after disinfecting with chlorhexidine. K. pneumonia (n= 13), H. influenza (n=11) and S. aureus (n=9) were still the most prevalent pathogens. Conclusions:This study demonstrated that 61 of the total of 113 pathogens isolated (54%), survived after 2 minutes of disinfecting the surgical and surrounding area with chlorhexidine, thus intensifying the chances of post-operative infection.

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Section: Pathogen (N) Antibiotic Resistant Cases (N)supporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

“…21 One study found that the efficacy of chlorhexidine was weak in comparison to other disinfectants against five pathogens.…”

Section: Pathogen (N) Antibiotic Resistant Cases (N)mentioning

confidence: 99%

mentioning

confidence: 99%

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A Descriptive Study of Chlorhexidine as a Disinfectant in Cleft Palate Surgery

Roode¹,

Bütow²

2018

Clin Med Res

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“…Both mupA and mupB are ileS genes imported from other species. A possible association between the presence of qac genes and resistance to MUP has been suggested [6,11].…”

Section: Introductionmentioning

confidence: 99%