Characteristics of primate spinothalamic tract neurons receiving viscerosomatic convergent inputs in T3-T5 segments

Blair, Robert W.; Weber, R. Neal; Foreman, Robert D.

doi:10.1152/jn.1981.46.4.797

Cited by 102 publications

(23 citation statements)

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“…In previous work (Blair et al, 1981b), we noted that every thoracic spinothalamic neuron studied responded to electrical stimulation of visceral afferent fibers. The present study confirms this observation.…”

Section: Discussion Bradykinin Responsesmentioning

confidence: 83%

“…A detailed description of our experimental setup has been published (Blair et al, 1981b). Briefly, catheters for recording aortic blood pressure and for administering drugs were implanted in the femoral artery and vein, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Once a spinothalamic cell was identified, the type of visceral afferent input it received was determined using the technique of minimum afferent conduction velocity (MACV) Blair et al, 1981b). Poststimulus histograms of a cell's reponse to sympathetic afferent nerve stimulation were constructed; generally, either one or two peaks appeared.…”

Section: Methodsmentioning

confidence: 99%

“…Although the emphasis of this study concerned visceral inputs of spinothalamic cells, each cell also was tested for somatic input as described previously (Blair et al, 1981b). All cells tested had somatic fields.…”

Section: Methodsmentioning

confidence: 99%

“…A pathway that might be expected to receive both visceral and somatic inputs is the spinothalamic tract. Recent studies have confirmed that spinothalamic neurons in the lumbosacral, lower thoracic, and upper thoracic spinal segments receive viscerosomatic convergent inputs (Hancock et al, 1975;Blair et al, 1981b;Foreman et al, 1981b;Milne et al, 1981). Clinically, two of the most significant kinds of referred pain are anginal pain and the pain associated with myocardial infarction.…”

Section: Responses Of Thoracic Spinothalamic Neurons To Intracardiac mentioning

confidence: 96%

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Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.

Blair¹,

Weber²,

Foreman³

1982

Circulation Research

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SUMMARY. Bradykinin stimulates afferent fibers arising in the heart and may be involved in the mediation of anginal pain and the pain associated with myocardial infarction. The sensation of pain requires that noxious information reach the brain. The purpose of the present study was to determine whether the spinothalamic tract is involved in transmitting noxious information from the heart to the brain. Bradykinin was injected (0.3-3.5 jug/kg) into the heart via a catheter in the left atrium while we recorded from single spinothalamic cells in the Cg to T 5 spinal segments. Thirty-one of 41 cells responded to bradykinin. The responses of 12 cells were characterized by both an increase in discharge rate and entrairrment of cell activity with the cardiac cycle. Eighteen cells responded with only an increased rate, and one cell exhibited only entrainment of cell activity with the cardiac cycle. The mean onset of increased cell activity occurred 15 seconds following drug injection, and the average duration of the response was 54 seconds. Thirty cells increased their mean discharge rate from 11 ± 2.5 to 29 ± 4.4 spikes/second. Thus, some spinothalamic cells probably received input from both mechanosensitive and chemosensitive afferents. Tachyphylaxis to repeated doses of bradykinin was observed in 41% of cells. Cells responding to bradykinin had a spontaneous discharge rate that was significantly greater than that of nonresponding cells. Cells did not require input from C-fiber afferents to respond to bradykinin. No statistically significant relationships were found among anatomical locations (laminae and segments) and responses to bradykinin, although cells in lamina I seemed to be less responsive than more ventrally located cells. We conclude that the spinothalamic tract may be involved in the sensation of cardiac pain. (Circ Res 51: 83-94, 1982)

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Section: Discussion Bradykinin Responsesmentioning

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Responses Of Thoracic Spinothalamic Neurons To Intracardiac mentioning

confidence: 96%

See 3 more Smart Citations

Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.

Blair¹,

Weber²,

Foreman³

1982

Circulation Research

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show abstract

Physiology of the Meningeal Sensory Pathway

Strassman

Melo‐Carrillo

2017

Neurobiological Basis of Migraine

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Convergence of sensory processes from the heart and left ulnar nerve onto a single afferent perikaryon: A neuroanatomical study in the rat employing fluorescent tracers

McNeill

Burden

1986

Anat. Rec.

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After injection of true blue (TB) into the pericardial sac and nuclear yellow (NY) into the left ulnar nerve of rats, most perikarya in the left eighth cervical and first thoracic dorsal root ganglia are single-labeled with either TB or NY. However, 7.1-14.7% of the sensory perikarya from the cardiac area labeled with TB are simultaneously labeled with NY. This finding indicates that some primary sensory perikarya receive processes from both the left arm and the heart. In addition to other mechanisms that may be operative in the referral of pain of cardiac origin to the medial left arm, these results suggest that sensory neurons with dichotomizing somatic and visceral peripheral processes may also contribute to this phenomenon.

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Characteristics of primate spinothalamic tract neurons receiving viscerosomatic convergent inputs in T3-T5 segments

Cited by 102 publications

References 0 publications

Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.

Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey.

Physiology of the Meningeal Sensory Pathway

Convergence of sensory processes from the heart and left ulnar nerve onto a single afferent perikaryon: A neuroanatomical study in the rat employing fluorescent tracers

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