BACKGROUND COVID-19 has caused significant mortality worldwide. 1 Within the USA, marked geographic differences in incidence, hospitalization, and death have been reported. 2 Better characterization of populations at increased risk for death from COVID-19 is needed, including from long-term care facilities (LTCF). We describe the demographic and clinical characteristics of the first 50 fatalities with COVID-19 in San Francisco. METHODS All San Francisco residents who die with laboratoryconfirmed COVID-19 infection are reported to the San Francisco Department of Public Health (SFDPH). We reviewed case report forms, medical records, and death certificate data for demographics, clinical presentation, and hospital course when applicable. Cause of death was not considered to be due to COVID-19 if not listed as the underlying cause of death on both the death certificate and medical record. These activities were public health surveillance, and not research; therefore, institutional review board review was not obtained.