Characteristics of Persistent Hyperparathyroidism After Renal Transplantation

Yamamoto, Takayuki; Tominaga, Yoshihiro; Okada, Manabu; Hiramitsu, Takahisa; Tsujita, Makoto; Goto, Norihiko; Narumi, Shunji; Watarai, Yoshihiko

doi:10.1007/s00268-015-3314-z

Cited by 33 publications

(32 citation statements)

References 25 publications

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“…The indication for surgery to treat THPT was based on the occurrence of severe hypercalcemia (ionized calcium > 1.80 mmol/dL) any time after RTx, persistent hypercalcemia for more than 12 months after RTx, kidney stone and/or nephrocalcinosis in a kidney graft or deterioration of the graft function associated with hyperparathyroidism at any time after RTx. 8 …”

Section: Methodsmentioning

confidence: 99%

Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder

et al. 2018

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Section: Methodsmentioning

confidence: 99%

Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder

et al. 2018

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“…Foi testada a correlação linear do PTH aos 12 meses com os níveis de cálcio, fósforo, Hb, creatinina, TFG, PAS e PAD aos 12 meses, e observou-se uma correlação inversa significativa com os níveis de fósforo (r = -0,407; p = 0,001) e uma tendência a correlação positiva com os níveis de cálcio (r = 0,216; p = 0,097 outros estudos previamente publicados 16,[18][19][20]24,25 (Tabela 3), observamos uma prevalência mais elevada em nossa população.…”

Section: Resultsunclassified

Hiperparatireoidismo pós-transplante em uma unidade de transplante renal do nordeste do Brasil: prevalência e aspectos clínicos

et al. 2019

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Introdução: o hiperparatireoidismo (HPT) após o transplante renal (Tx) tem prevalência variável e impacto negativo na sobrevida do enxerto/paciente. Objetivo: avaliar a prevalência de HPT persistente em uma unidade de Tx renal e a correlação entre o paratormônio (PTH) e variáveis clínicas/laboratoriais. Métodos: foi considerado HPT persistente níveis de PTH ≥ 100pg/ml após 12 meses (m) de Tx, sendo testada a correlação do PTH com tempo em diálise, creatinina, taxa de filtração glomerular, cálcio, fósforo, Hb, pressão arterial sistólica (PAS) e pressão arterial diastólica (PAD). Resultados: analisados 68 pacientes, idade média de 43 anos, 70,6% do masculino. HPT foi observado em 88% aos 12 m e 33% aos 24 m. Houve correlação linear negativa significativa do PTH com o fósforo aos 12 m e positiva com a PAD aos 24 m e entre o tempo em diálise e o PTH pré-Tx aos 12 e 24 meses. Entre os grupos com PTH < 100 pg/ml e PTH ≥ 100 pg/ml, foi observado diferença significativa em relação ao fósforo aos 12 m (p=0,040); creatinina (p=0,018) e taxa de filtração glomerular (TFG) (p= 0,020) aos 24 m. Conclusão: a prevalência de HPT persistente no primeiro ano após o Tx renal foi elevada, com melhora nesta taxa após 24 meses. Foi detectada correlação significativa do PTH com o tempo em diálise, fósforo e a PAD, assim como houve uma diferença significativa entre os grupos de PTH para o fósforo aos 12 m, e creatinina e TFG aos 24 m. Estudos adicionais e com delineamento prospectivo permitirão melhor investigação do HPT pós-Tx, incluindo aspectos de prevenção, tratamento e morbimortalidade.

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“…PHPT is a common problem after successful KT, and the incidence has been reported to range from 10% to 75% . PHPT is characterized by an autonomous pattern of PTH secretion .…”

Section: Introductionmentioning

confidence: 99%

Risk factors for persistent hyperparathyroidism in children with stable renal function after kidney transplantation

Kim

Lee

Han

2018

Pediatric Transplantation

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This study aimed to investigate the risk factors for PHPT in children with stable renal function who received KT. We retrospectively analyzed the clinical findings and laboratory results of patients who underwent KT below 19 years of age, between 1996 and 2016 at our hospital. Patients were followed up for more than 1 year after KT. We calculated the mean ± standard deviation or median [minimum - maximum] for each parameter. We included a total of 46 patients (male:female = 26:20). Twelve patients (26.1%) were included in the PHPT group, and 34 (73.9%) were in the nPTH group. The dialysis duration was 57.1 ± 49.9, 44 [0-145] months in the PHPT group and 23.5 ± 25.8, 15 [1-121] months in the nPTH group (P = .040). The post-KT total CO level was significantly higher in the PHPT group (P = .022). The pre- (P = .021) and post-KT (P = .005) and 3-month average (P = .018) iPTH levels were also significantly higher in PHPT group. The height z-score showed a negative correlation, and the pre-KT, 3-month average phosphorus and alkaline phosphate levels showed positive correlations with iPTH levels, at 1 year after KT. Patients who undergo prolonged durations of dialysis, have increased iPTH levels before and after KT, and have low bicarbonate levels after KT are at risk of PHPT and should be monitored carefully.

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Characteristics of Persistent Hyperparathyroidism After Renal Transplantation

Cited by 33 publications

References 25 publications

Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder

Initial surgical results of 500 Parathyroidectomies for Hyperparathyroidism related to chronic kidney disease - mineral and bone disorder

Hiperparatireoidismo pós-transplante em uma unidade de transplante renal do nordeste do Brasil: prevalência e aspectos clínicos

Risk factors for persistent hyperparathyroidism in children with stable renal function after kidney transplantation

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