2021
DOI: 10.3389/fmed.2021.689865
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Characteristics of Peripheral Lymphocyte Subsets in Patients With Acute-On-Chronic Liver Failure Associated With Hepatitis B

Abstract: Background and Aims: Acute-on-chronic liver failure (ACLF) is a rare, but dramatic clinical syndrome. There is substantial evidence suggesting that immunity-mediated inflammation plays an important role in HBV-ACLF. Our aim was to characterize the proportion and cell counts of peripheral blood lymphocyte subsets in acute-on-chronic liver failure patients caused by HBV infection.Methods: One hundred and seventeen patients were enrolled in this study, including those with HBV-related ACLF (HBV-ACLF; n = 70), and… Show more

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Cited by 5 publications
(4 citation statements)
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“…The peripheral blood CD8 + T cell counts are found significantly decreased in ACHBLF patients compared with CHB patients and healthy subjects in other studies, [73,74] CD8 + T cell counts are dramatically reduced in non-survivors of ACHBLF patients. [73] An investigation studied dysregulated adaptive immunity in liver cirrhosis preceding the development of ACLF, and has found simultaneous increase of co-stimulatory (e.g. CD40L, OX40, CD69, GITR, TIM-1) and inhibitory immune checkpoints (e.g.…”
Section: T Cellsmentioning
confidence: 58%
See 1 more Smart Citation
“…The peripheral blood CD8 + T cell counts are found significantly decreased in ACHBLF patients compared with CHB patients and healthy subjects in other studies, [73,74] CD8 + T cell counts are dramatically reduced in non-survivors of ACHBLF patients. [73] An investigation studied dysregulated adaptive immunity in liver cirrhosis preceding the development of ACLF, and has found simultaneous increase of co-stimulatory (e.g. CD40L, OX40, CD69, GITR, TIM-1) and inhibitory immune checkpoints (e.g.…”
Section: T Cellsmentioning
confidence: 58%
“…Although several studies demonstrate no significant difference in the proportion of total CD8 + T cells between ACLF patients and CHB patients, [52] the results are supposed to be questionable. The peripheral blood CD8 + T cell counts are found significantly decreased in ACHBLF patients compared with CHB patients and healthy subjects in other studies, [73,74] CD8 + T cell counts are dramatically reduced in non-survivors of ACHBLF patients [73] . An investigation studied dysregulated adaptive immunity in liver cirrhosis preceding the development of ACLF, and has found simultaneous increase of co-stimulatory (e.g.…”
Section: Innate Immune Cells In Achblfmentioning
confidence: 87%
“…Decreased lymphocyte count, reflecting reduced immune and inflammatory status ( 27 ), which may exacerbate the immunosuppression in ACLF ( 28 ). The lymphocyte count, especially for CD8 + T cell, have been found significantly decreased in non-survivors compared with survivors of HBV-ACLF ( 29 ). Similarly, studies suggest that decreased total cholesterol represents deterioration of nutritional status and exacerbates inflammation, posing a higher risk of death in older patients ( 30 , 31 ).…”
Section: Discussionmentioning
confidence: 99%
“…Better knowledge of the pathophysiology of these diseases can provide insights into novel therapies. It has been reported that the development of both ALF and ACLF is driven by immune dysfunction and inflammatory imbalance, although the conditions are distinct clinical entities (3)(4)(5). The immune and inflammatory status of the diseases is dynamic, progressing from intensive inflammation to the development of immunoparalysis (3,4,6).…”
Section: Introductionmentioning
confidence: 99%