Characteristics of peripheral blood differential counts in hospitalized patients with COVID‐19

Pakos, Irene S.; Lo, Kevin Bryan; Salacup, Grace; Pelayo, Jerald; Bhargav, Ruchika; Peterson, Eric; Gul, Fahad; DeJoy, Robert; Albano, Jeri; Patarroyo‐Aponte, Gabriel; Rangaswami, Janani; Azmaiparashvili, Zurab

doi:10.1111/ejh.13509

Cited by 30 publications

(33 citation statements)

References 23 publications

(38 reference statements)

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“…A single-center retrospective study of 242 COVID-19 cases with 52 patient death, found that the median absolute monocyte count was signi cantly reduced in the death group, while the NLR was signi cantly increased in the survival group [20]. In our research, there was no patient death in the COVID-19 group, with the median monocyte count within the normal range.…”

Section: Discussionsupporting

confidence: 45%

Comparative study of hematological and radiological feature of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia

Kong

Wan²,

Shi

et al. 2020

Preprint

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Objectives This study aimed to explore useful clinical indexes for management of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia by comparing hematological and radiological characteristics between them. Methods Severe/critically ill patients with confirmed diagnosis of COVID-19, Influenza A H7N9 and H1N1 pneumonia were retrospectively enrolled. The demographic data, clinical manifestations, hematological parameters, and radiological characteristics of three groups were compared. The influenza A was divided into two groups with/without patient death. Results In this study, 16 cases of COVID-19, 10 cases of influenza A (H7N9), and 13 cases of influenza A (H1N1) who met severe/critically ill criteria were included. Compared with COVID-19, the Influenza A (H7N9 and H1N1) groups had relatively more chronic diseases (80% and 92.3% vs 25%, P༜0.05), higher APACHE Ⅱ scores (16.00 ± 8.63 and 15.08 ± 6.24, vs 5.50 ± 2.58, P༜0.05) and higher mortality rates (40% and 46.2% vs 0%, P༜0.05). The hematological finding indicated that Influenza A H7N9 and H1N1 patients had more significant lymphocytopenia (0.59 ± 0.31 × 109/L and 0.56 ± 0.35 × 109/L vs 0.97 ± 0.33 × 109/L, P < 0.05), elevated neutrophil to lymphocyte ratio (NLR; 14.67 ± 6.10 and 14.64 ± 10.36 vs 6.29 ± 3.72, P < 0.05) compared to COVID-19. Especially in influenza A patients, NLR was significant different between the patients with or without death. Compared with the H7N9 group, ground glass opacity (GGO) on chest CT was more common in the COVID-19 group (P = 0.028), while pleural effusion was relatively rare (P = 0.001). Conclusion Compared to COVID-19, patients with Influenza A (H7N9 and H1N1) had more underlying chronic diseases and higher mortality rates. The NLR can be used as a clinical parameter for the predication of risk stratification and outcome in COVID-19 and Influenza A pneumonia. Manifestations of pleural effusion or GGO in chest CT may be helpful for the identification of different viral pneumonia.

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Section: Discussionsupporting

confidence: 45%

Comparative study of hematological and radiological feature of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia

Kong

Wan²,

Shi

et al. 2020

Preprint

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“…This hyperresponsiveness was also found in other studies [ 224 ]. Some clinical studies report that thrombocytopenia is associated with increased mortality [ 4 , 5 ], whereas other do not [ 215 , 225 ]. This discrepancy might depend on disease severity, comorbidities or the type of care provided.…”

Section: Resultsmentioning

confidence: 99%

“…The incidence of thromboembolic complications is elevated in individuals during and after influenza virus infection, for example, a relation which may not be apparent to physicians diagnosing and treating influenza-like illness [ 1 ]. Platelet counts during peak symptomatic disease have also been found to be a marker of disease severity in certain viral infections, [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ] or can serve as a first clue towards diagnosing chronic viral infections [ 20 , 21 , 22 , 23 ]. These phenomena are typically not explained by changes in platelet quantity, but rather by the effects of viral infections on platelet function.…”

Section: Introductionmentioning

confidence: 99%

Thrombocytopenia in Virus Infections

Raadsen

Toit

Langerak

et al. 2021

JCM

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Thrombocytopenia, which signifies a low platelet count usually below 150 × 109/L, is a common finding following or during many viral infections. In clinical medicine, mild thrombocytopenia, combined with lymphopenia in a patient with signs and symptoms of an infectious disease, raises the suspicion of a viral infection. This phenomenon is classically attributed to platelet consumption due to inflammation-induced coagulation, sequestration from the circulation by phagocytosis and hypersplenism, and impaired platelet production due to defective megakaryopoiesis or cytokine-induced myelosuppression. All these mechanisms, while plausible and supported by substantial evidence, regard platelets as passive bystanders during viral infection. However, platelets are increasingly recognized as active players in the (antiviral) immune response and have been shown to interact with cells of the innate and adaptive immune system as well as directly with viruses. These findings can be of interest both for understanding the pathogenesis of viral infectious diseases and predicting outcome. In this review, we will summarize and discuss the literature currently available on various mechanisms within the relationship between thrombocytopenia and virus infections.

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“…In our patients, the WBC were elevated in 33.7% of the patients, while 64% of patients had WBC count within the normal range. The correlation was significant between the infection and WBC count (P = 0.000); the majority of the published studies found a similar correlation with the WBC count (11,12).…”

Section: Discussionmentioning

confidence: 63%

Hematological Parameters in Adult Patients with COVID-19; A Case-Control Study

Ahmed

Mohammed

2021

Int J Infect

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Background: The coronavirus disease 2019 (COVID-19) pandemic is a serious public health concern worldwide. The virus mainly causes respiratory symptoms, but its manifestations might be different. Assessments showed that COVID-19 can cause various alterations in the blood parameters. Objectives: This study aimed to detect the most common changes in the blood parameters in COVID-19 patients and compare them with healthy individuals. Methods: In this study, 350 individuals were grouped into two equal groups of COVID‐19 patients and healthy controls. Results: The mean age of patients was 53.73 years, and males constituted 52.57% of them. Middle aged patients constituted about 55.43% of participants, elderly patients 26.29%, and young patients 18.29%. There was a significant correlation between COVID-19 and all the blood parameters, including Hb, MCV, WBC, neutrophils, lymphocytes, monocytes, eosinophils, and platelets (P = 0.000). Conclusions: Infection with COVID-19 is associated with multisystem symptoms and signs, as well as numerous laboratory abnormalities. An increased focus should be on changes in the blood parameters as valuable markers in suggesting the infection when the reverse transcription polymerase chain reaction (RT-PCR) is negative. These parameters can give clues about the severity of the infection and predict the admission to the intensive care unit (ICU).

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Characteristics of peripheral blood differential counts in hospitalized patients with COVID‐19

Cited by 30 publications

References 23 publications

Comparative study of hematological and radiological feature of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia

Comparative study of hematological and radiological feature of severe/critically ill patients with COVID-19, Influenza A H7N9 and H1N1 pneumonia

Thrombocytopenia in Virus Infections

Hematological Parameters in Adult Patients with COVID-19; A Case-Control Study

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