Characteristics of patients with abnormal glucose challenge test and normal oral glucose tolerance test results: Comparison with normal and gestational diabetic patients

Dudhbhai, Munira; Lim, Louis; Bombard, Allan T.; Juliard, Kell; Meenakshi, Bhillakar; Trachelenberg, Yelena; Weiner, Zeev

doi:10.1016/j.ajog.2005.11.031

Cited by 25 publications

(25 citation statements)

References 8 publications

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“…The present study used a low 1-hour plasma glucose cutoff value for the GCT coupled with a follow on diagnostic test based on the low threshold WHO (1999) criteria; sensitivity for identifying GDM was thus maximal for a 2-step process and the GDM rate in the study population of 1368 women was 12.3%-the highest rate of GDM compared with previous studies [7][8][9]. Our criteria for screening and GDM would likely result in GCT false-positives that would be at the lowest risk of hyperglycemia compared with other reports that have used higher screening or diagnostic thresholds.…”

Section: Discussionmentioning

confidence: 87%

“…Previous studies on false-positive GCT have yielded conflicting results, in part due to different thresholds used for the GCT screen, different diagnostic criteria for GDM and importantly in populations with different GDM prevalence [7][8][9][10].…”

Section: Discussionmentioning

confidence: 96%

“…Recent reports on women with false-positive GCT screens have yielded conflicting results, with some studies showing increased risk of adverse pregnancy outcome [7,8] while others have reported no difference [9,10]. These studies were in populations at low to moderate risk of GDM, and used different GCT cutoffs and different diagnostic criteria.…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

The 50‐g glucose challenge test and pregnancy outcome in a multiethnic Asian population at high risk for gestational diabetes

Tan

Ling

Omar

2009

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

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The 50‐g glucose challenge test and pregnancy outcome in a multiethnic Asian population at high risk for gestational diabetes

Tan

Ling

Omar

2009

Intl J Gynecology & Obste

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“…A change of 10% or greater was used as an indicator of confounding. Because age is considered an important risk factor in the development of glucose disturbances and because prior studies have adjusted for this, [37, 47, 48] age was retained in the models even though it did not change the estimate by 10%. Based on findings in the published literature, [37] the potential modifying effect of prepregnancy BMI on weight gain was evaluated by testing the interaction between these two variables.…”

Section: Methodsmentioning

confidence: 99%

The Impact of Gestational Weight Gain and Diet on Abnormal Glucose Tolerance During Pregnancy in Hispanic Women

Tovar

Must

Bermúdez

et al. 2008

Matern Child Health J

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Objective To examine the association of gestational weight gain and dietary factors with abnormal glucose tolerance (AGT). Methods We conducted a prospective cohort study among 813 Hispanic prenatal care patients in Massachusetts. Gestational weight gain and oral glucose tolerance test results were abstracted from medical records. Dietary intake was assessed using a semi-quantitative food frequency questionnaire. Target weight gain was based on BMI-specific weekly weight gain rates established by the Institute of Medicine (IOM). Results We observed a statistically significant interaction between prepregnancy BMI and weight gain in relation to AGT (P < 0.01). Class II/III (BMI ≥ 35 kg/m2) obese women who had a high rate of weight gain (>0.30 kg/week) or who exceeded target weight were 3–4 times as likely to develop AGT compared to women who gained within IOM ranges (OR = 4.2, 95% CI 1.1–16.0, OR = 3.2 95% CI 1.0–10.5, respectively). Increasing levels of saturated fat and fiber and decreasing levels of energy-dense snack foods and polyunsaturated fat:saturated fat ratio were significantly associated with increased risk of AGT, independent of gestational weight gain. Conclusions Weight gain among class II/III obese women and certain dietary components may represent modifiable risk factors for AGT.

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“…The relationship between GDM and maternal age has been investigated in various studies. In a study performed by Dudhbhai M et al, the authors showed that the age of patients with impaired 100-g OGTT and GDM were higher compared to those with normal OGTT (15).…”

Section: Discussionmentioning

confidence: 99%

50 G Glukoz Yükleme Testinin Gestasyonel Diyabet Tanısındaki Etkinliği

İnan¹,

Ağır²,

Sağır³

2014

Haseki

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ÖzetAmaç: Bu çalışmada amacımız, 50 g glukoz challenge test (GCT) ile açlık kan glukoz değerlerinin gestasyonel diyabet (GDM) tanısında etkinliğini araştırmak, tarama için bir cut-off değeri belirlemektir. Yöntemler: Dörtyüz kırk dört gebeye 24-28 gestasyonel haftaları arasında 50 gr GCT uygulandı. Gestasyonel diyabet hastalarını atlamamak için eşik değer 130 mg/dl olarak alındı. Plazma glukoz düzeyinin birinci saatte 130 mg/dl ve üzerindeki sonuçlar pozitif olarak kabul edildi ve bu gebelere 100 gr oral glukoz tolerans testi (OGTT) uygulandı. Bulgular: 50 g GCT için cut-off değeri 145 mg/dl olarak bulundu. 145 mg/dl ve üzerindeki değerlerde testin GDM'yi öngörmede duyarlılık %96,30; özgüllük %80,34 olarak belirlendi. Açlık kan glukoz cut-off değeri için belirlenen 88 mg/dl'da duyarlılığın % 48,15 özgüllüğün %70,84 olduğu bulundu. Sonuç: Özellikle 50 g GCT'de birinci saat kan glukoz değeri 145mg/dl ve üzerindeki değerlerde gestasyonel diyabet tanısı koymada etkiniliğin arttığı , açlık kan glukoz düzeyinin GDM için iyi bir tarama testi olamayacağı sonucuna varıldı. Abs tractAim: Our aim in this study was to investigate the efficacy of 50 g glucose challenge test (GCT) in the diagnosis of gestational diabetes mellitus (GDM) and to determine a cut-off value for screening. Methods: 50-g GCT was performed in 444 pregnant women at 24-28 gestational weeks. The threshold was taken as 130 mg/dl in order not to miss GDM cases. A plasma glucose level of ≥130 mg/ dl at the first hour was considered to be a positive result and 100-g oral glucose tolerance test (OGTT) was given to these women. Results: The cut-off value for 50-g GCT was found to be 145 mg/ dl. The sensitivity and specificity of the test for predicting GDM at the levels of ≥145 mg/dl were determined to be 96.30% and 80.34%, respectively. The sensitivity and specificity of the test at the level of 88 mg/dl determined for fasting blood glucose cut-off value were found to be 48.15% and 70.84%, respectively. Conclusion: It was concluded that the efficacy in making diagnosis of GDM was increased at the first hour blood glucose levels of ≥145 mg/dl, especially in 50-g GCT, and fasting blood glucose level could not be a good screening test for GDM. (The Me di cal Bul le tin of Ha se ki 2014; 52: 181-6)

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Characteristics of patients with abnormal glucose challenge test and normal oral glucose tolerance test results: Comparison with normal and gestational diabetic patients

Cited by 25 publications

References 8 publications

The 50‐g glucose challenge test and pregnancy outcome in a multiethnic Asian population at high risk for gestational diabetes

The 50‐g glucose challenge test and pregnancy outcome in a multiethnic Asian population at high risk for gestational diabetes

The Impact of Gestational Weight Gain and Diet on Abnormal Glucose Tolerance During Pregnancy in Hispanic Women

50 G Glukoz Yükleme Testinin Gestasyonel Diyabet Tanısındaki Etkinliği

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