Characteristics of patients admitted to internal medicine departments with high serum cobalamin levels: Results from a prospective cohort study

Brah, Souleymane; Chiche, Laurent; Mancini, Julien; Meunier, B.; Arlet, Jean‐Benoît

doi:10.1016/j.ejim.2014.01.014

Cited by 19 publications

(7 citation statements)

References 10 publications

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“…Until recently, hypercobalaminemia was considered as a benign finding and was basically ignored in companion animals. However, recent data in people suggest that hypercobalaminemia is an underestimated finding that can reflect a number of serious underlying diseases such as solid neoplasms, hematological and other malignancies, and hepatic or renal diseases . Abnormally high serum cobalamin concentrations occur in cats with hepatic and neoplastic diseases .…”

Section: Laboratory Testing To Evaluate Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

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Disorders of cobalamin (vitamin B 12 ) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with serum folate concentration, is routinely performed as a diagnostic test in clinical practice. While the detection of hypocobalaminemia has therapeutic implications, interpretation of cobalamin status in dogs can be challenging. The aim of this review is to define hypocobalaminemia and cobalamin deficiency, normocobalaminemia, and hypercobalaminemia in dogs, describe known cobalamin deficiency states, breed predispositions in dogs, discuss the different biomarkers of importance for evaluating cobalamin status in dogs, and discuss the management of dogs with hypocobalaminemia. K E Y W O R D S cobalamin deficiency, cubam receptor, folate, homocysteine, hypercobalaminemia, hypocobalaminemia, methylmalonic acid, vitamin B 12

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Section: Laboratory Testing To Evaluate Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

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“…These persons have gained attention in recent years, because an association between elevated B12 levels and cancer has been reported in several studies. Four cross-sectional studies reported a higher prevalence of cancer among hospital patients with high B12 levels compared with patients with normal B12 levels (2,(4)(5)(6). In addition, two cohort studies showed that patients with elevated plasma B12 levels had 6 to 15 times higher short-term risk of cancer compared with the general population in Denmark (3,7).…”

Section: Introductionmentioning

confidence: 99%

Elevated Vitamin B12 Levels and Cancer Risk in UK Primary Care: A THIN Database Cohort Study

Arendt

Sørensen

Horsfall

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. However, the implications for early cancer detection in primary care have not been assessed. Methods: Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. Persons with low B12 levels were excluded together with persons with cancer or B12 treatment before date of B12 measurement. Incident cancer was the outcome of interest and was identified through Read codes. Individuals were disaggregated according to plasma B12 levels (unit: pmol/L): 150-600 (reference range values), 601-800, 801-1,000, and >1,000. Results: Among the 757,185 persons who met the inclusion criteria, we identified 33,367 incident cancers during 2,874,059 years of follow-up. We found a higher 1-year cancer risk among the 25,783 (3.4%) persons with elevated B12 levels compared with those with normal B12 levels. After multivariable adjustment for lifestyle factors and social deprivation, persons with B12 >1,000 pmol/L had a 1-year incidence rate ratio of 4.72 (95% confidence interval: 3.99-5.58). The association showed a nonlinear dose-response pattern, and it remained robust in stratified analyses, including when reducing the risk of confounding by indication in subanalyses. The risks were particularly elevated for liver cancer, pancreas cancer, and myeloid malignancies among persons with elevated B12 levels. Conclusions: Elevated plasma B12 levels were associated with a higher 1-year cancer risk than normal B12 levels among persons seen in UK primary care, suggesting that some cancers may affect B12 metabolism. Impact: Elevated B12 may mark occult cancer.

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“…But, see both high and low Cbl test results. [4][5][6][7] Our cases are also determined by test request for deficiency suspicion.…”

Section: Discussionmentioning

confidence: 99%

“…They reported that 1% of samples are from patients with myeloproliferative disease. [4][5][6][7] However, there is no report on clinical follow up of adult or child patients with high vitamin B12 values.…”

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confidence: 99%

Clinical follow-up of children with high vitamin B12 values: should we worry?

Albayrak¹,

Albayrak²

2021

Turk J Pediatr

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Vitamin B12 (cobalamin, Cbl) is one of the most important vitamins that can be dissolved in water. It is absorbed in terminal ileum, transported by haptocorrins and stored in the liver. It is involved in methyl transfer and nucleotide synthesis. In children, deficiency leads to megaloblastic anemia and affects neurologic development. The importance of deficiency in children is well understood. There are many studies about vitamin B12 deficiency. [1][2][3] The widespread use of autoanalysers in hospital laboratories has made vitamin B12 testing, like many tests, widespread, inexpensive, fast and accessible everywhere. Thus, all doctors, especially pediatricians, internist and neurologists, have started to request vitamin B12 tests from every patient in which the deficiency might have an impact or relation. Important data have accumulated in laboratory recording systems due to the increased requests. Analysis of these data showed that a significant proportion of the vitamin B12 tests were higher than normal. 1-3 Thus, a new research area related to vitamin B12 levels was opened. The new questions are what is the meaning of this high vitamin B12 (hCbl) level found incidentally high in a patient and how to manage such a patient. These questions are very important, because the high levels of Cbl are seen in malign or proliferative diseases of myeloid and lymphoid

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Characteristics of patients admitted to internal medicine departments with high serum cobalamin levels: Results from a prospective cohort study

Cited by 19 publications

References 10 publications

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Elevated Vitamin B12 Levels and Cancer Risk in UK Primary Care: A THIN Database Cohort Study

Clinical follow-up of children with high vitamin B12 values: should we worry?

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