Characteristics of P-Type and N-Type Photoelectrochemical Biosensors: A Case Study for Esophageal Cancer Detection

Abstract

P-type and N-type photoelectrochemical (PEC) biosensors were established in the laboratory to discuss the correlation between characteristic substances and photoactive material properties through the photogenerated charge carrier transport mechanism. Four types of human esophageal cancer cells (ECCs) were analyzed without requiring additional bias voltage. Photoelectrical characteristics were examined by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV–vis reflectance spectroscopy, and photocurrent response analyses. Results showed that smaller photocurrent was measured in cases with advanced cancer stages. Glutathione (L-glutathione reduced, GSH) and Glutathione disulfide (GSSG) in cancer cells carry out redox reactions during carrier separation, which changes the photocurrent. The sensor can identify ECC stages with a certain level of photoelectrochemical response. The detection error can be optimized by adjusting the number of cells, and the detection time of about 5 min allowed repeated measurement.

Advancement in Biosensor Technologies of 2D MaterialIntegrated with Cellulose—Physical Properties

“…These materials can interact with light and electrical fields, making them particularly suitable for biosensor applications that require precise electrical characteristics [ 3 ]. Also, studies enhance the role of 2D materials in cancer biosensors: a MoS 2 /Cu 2 O sensor for lung cancer detection [ 4 ], PEC biosensors for esophageal cancer [ 5 ], and a lab-on-chip design for broad cancer cell detection [ 6 ]. These highlight advancements in material use and detection techniques, aiding early cancer diagnosis.…”

Evaluating Hyperspectral Techniques Using Objective Metrics Research on Analog Narrowband Image

“…In one such study by Wang et al, a photoelectrochemical (PEC) biosensor based on p-Cu2O and n-ZnO heterostructure was developed to detect EC [23]. Leung et al conducted a case study of the characteristics of P-Type and N-Type PEC biosensors for EC detection [24]. Clinical and other practical uses of the optical biosensor are limited by high background noise, multiplexing, environmental interference, poor sensitivity and output signal intensity, high detection limit, and speci city [25].…”