Characteristics of Outcome in Schizophrenia at 13 Years

Mason, Peter R.; Harrison, Glynn; Glazebrook, Cris; Medley, Ian; Dalkin, T.; Croudace, Tim

doi:10.1192/bjp.167.5.596

Cited by 128 publications

(80 citation statements)

References 22 publications

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“…Another possibility could be that the processes of aging and the possibility of psychopathological improvement during the later stages of schizophrenia (Bleuler, 1978;Ciompi, 1980;Harding et al, 1987;Mason et al, 1995) "neutralize" each other, producing effectively unchanged performance across this age span. The clinical measures used in this study (e.g.…”

Section: Discussionmentioning

confidence: 99%

Aging and visual motion discrimination in normal adults and schizophrenia patients

Bidwell

Holzman

Chen

2006

Psychiatry Research

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Motion perception is impaired in many neuropathological conditions, including schizophrenia. Motion perception also declines in the course of normal aging. In this study, we ask whether aging is an additive factor in the motion-discrimination deficits of schizophrenia patients. We examined motion perception in schizophrenia patients (n =44) and non-psychiatric controls (n =40) whose ages ranged from 18 to 55. The tasks included velocity discrimination and contrast detection. Thresholds for each of the two tasks were determined for each subject using psychophysical methods. Schizophrenia patients showed significantly increased thresholds (degraded performance) for velocity discrimination compared with the controls. Degraded performance in patients was not related to age. In controls, however, velocity discrimination thresholds were significantly increased beginning by age 45. Performance on a contrast-detection task, which does not require precise discrimination of motion signals, was not significantly affected by age in either group. Aging, even in its early stages, degrades motion discrimination in normal adults. Aging, however, does not adversely affect motion-discrimination deficits in schizophrenia patients through age 55. A similar motion-discrimination deficit in schizophrenia patients and aging normal adults suggests that the mechanisms underlying motion processing in schizophrenia and normal aging may be associated.

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Section: Discussionmentioning

confidence: 99%

Aging and visual motion discrimination in normal adults and schizophrenia patients

Bidwell

Holzman

Chen

2006

Psychiatry Research

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“…It has been observed that on many measures the illness reaches its peak of severity after 2^5 years, after which the level of disability remains the same or may decrease^the`plateau effect' (McGlashen, 1988). Long-term outcome studies (Mason et al, 1996;Warner, 1994) have confirmed the heterogeneity of outcome in schizophrenia.…”

Section: The Early Intervention Movementmentioning

confidence: 93%

Service innovations: early intervention in psychosis as a core task for general psychiatry

Whitwell

2001

Psychiatr. bull.

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Early intervention in psychosis is a strategy for which there is increasing theoretical and pragmatic justification. Many studies have been published describing the benefits of early intervention as carried out by specialised and innovative projects. The present paper describes how a generic community mental health team (CMHT), covering a population of 50 000, introduced strategies for early intervention with no extra funding. The team worked together to change old attitudes and practices. A style of intervention was developed to engage with and keep in contact with people with recent onset psychosis. This appears to be achievable – and this model may be an alternative to the setting up of specialised teams.

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“…[50][51][52] However, within the first year, recurrence is observed in up to 25% of patients, 53 rising to almost 50% within 2 years. 50,54,55 Within 12 months it has also been found that 14% of patients are treatment resistant, 56 and over 2 years' duration 20-45% are only partially responsive to antipsychotic medication, 57,58 with 5-10% of patients deriving no benefit at all. 59 However, the prevalence of treatment resistance is hard to determine given the lack of agreement on defining the term, and, as these figures also reflect treatment outcomes with typical antipsychotics, with atypical antipsychotics now also being widely available, it has been argued there is a need to reconsider what constitutes 'non-response'.…”

Section: Schizophreniamentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation

Fleeman

McLeod²,

Bagust³

et al. 2010

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address. Paying by credit cardYou can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume. How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projec...

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Characteristics of Outcome in Schizophrenia at 13 Years

Abstract: The findings reported are similar to those of other long-term follow-up studies of schizophrenia and also to 5-year follow-up studies. Kraepelin's emphasis on the longitudinal implications of a diagnosis of schizophrenia are supported, but may be over-pessimistic.

Cited by 128 publications

References 22 publications

Aging and visual motion discrimination in normal adults and schizophrenia patients

Aging and visual motion discrimination in normal adults and schizophrenia patients

Service innovations: early intervention in psychosis as a core task for general psychiatry

The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation

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