Characteristics of Orbital Multiple Myeloma: A Case Report and Literature Review

Secondary Plasmacytoma of The Orbit In A Patient With Refractory Ig G Kappa Multiple Myeloma

“…Superotemporal orbit and extraconal location of the orbit is considered as the common location for MM due to the rich blood supply to the lacrimal gland & extraocular muscles, presence of extensive marrow in orbital bones, and also may be lacrimal system is more prone to metastasis than other orbital sites. 7,8 Our patient also had extraconal superotemporal orbital infiltration by the MM like other cases reported in the literature. Treatment of the orbital lesions includes local excision as a salvage surgery, exenteration or radiotherapy and additional chemotherapy.…”

“…However, orbital involvement carries worse prognosis with decrease in the overall survival to approximately 20-30 months. 4,7,8 Our patient survived for approximately 28 months since the diagnosis of MM and for 4 months since the orbital presentation. In summary, we report a case of recurrent refractory Ig G kappa MM with orbital infiltration along with skull base and spine involvement.…”

“…2 The average age of ocular involvement by plasmacytoma is after 50 years and most common presentation is exophthalmos (42/52, 81%) and interval to development of orbital lesions since the primary diagnosis of MM is average of 18 months. [8][9][10] Our patient with an established diagnosis of MM presented with progressive exophthalmos at the age of 52 years and had orbital involvement approximately 24 months after the primary diagnosis of MM. Superotemporal orbit and extraconal location of the orbit is considered as the common location for MM due to the rich blood supply to the lacrimal gland & extraocular muscles, presence of extensive marrow in orbital bones, and also may be lacrimal system is more prone to metastasis than other orbital sites.…”

Good Anatomical Outcome of Orbital Plasmacytoma Following Chemo-Radiotherapy

“…Common ocular findings are crystal or copper deposits on the cornea, ciliary body cyst, retinal haemorrhages and exudative macular detachment which were not present in our patient. The two pathophysiological process of ocular manifestations are infiltration of tissue cells by plasma cells and haematological abnormalities from increased blood viscosity (Burkat et al 2009). …”

Isolated orbital relapse of multiple myeloma in a patient with severe chronic GVHD after allogeneic hematopoietic SCT

“…4 Orbital involvement as an indicator of extramedullary recurrence of multiple myeloma in patients thought to be in remission is an exceptional case. 5 Common symptoms of orbital involvement by multiple myeloma are proptosis, decreased vision, diplopia, swelling and ptosis. Our patient presented with a subconjunctival swelling in the right eye as unspecific early finding followed by the above-mentioned typical symptoms of an orbital lesion later with histopathology confirming diagnosis.…”