Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study

Harada, Hiroyuki; Kikuchi, Masahiro; Asato, Ryo; Hamaguchi, Kozo; Tamaki, Hisanobu; Mizuta, Masanobu; Hori, Ryusuke; Kojima, Tsuyoshi; Honda, Kazuhisa; Terauchi, Takashi; Kumabe, Yohei; Ichimaru, Kazuyuki; Kitani, Yoshiharu; Ushiro, Koji; Kitamura, Morimasa; Shinohara, Shogo; Omori, Koichi

doi:10.1002/hed.27398

Cited by 8 publications

(7 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical features such as the location and size of the tumor are crucial factors in determining the progression and prognosis of the disease. Our observations revealed that the buccal mucosa was the most frequent site of tumor development, followed by the tongue, contrary to the literature, which states that the tongue is the most common site [ 14 ].…”

Section: Discussioncontrasting

confidence: 99%

A Study of Histological and Clinical Parameters and Their Correlation With Lymph Node Metastasis and Two-Year Survival in 50 Cases of Oral Squamous Cell Carcinoma

Singh,

Somani,

Poduwal

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction: Oral squamous cell carcinoma (OSCC) is one of the most prevalent malignant neoplasms in South Asia and a major public health problem in India. The purpose of the study was to identify correlations among various clinicopathological parameters of OSCC in a tertiary care center in the Eastern Uttar Pradesh population of North India. The study is imperative due to the scarcity of available data from this region. Methodology: A retrospective observational study was conducted on the cases received in the Department of Pathology over the period of January 2021 to December 2021. The study analyzed cases of OSCC, focusing on various factors such as age, gender, habits, tumor site, tumor size, differentiation, tumor-stroma ratio, tumor-infiltrating lymphocytes, tumor budding, worst pattern of invasion, depth of invasion, perineural invasion, lymphovascular invasion, underlying bone and overlying skin involvement, regional lymph node metastasis, and overall two-year survival. Results: The mean age of the patients was 47.80 ± 12.48 years, and the male-to-female ratio was 15.6:1. Buccal mucosa was the most frequently affected site followed by the tongue. Fifty-six percent of cases reported with a history of tobacco abuse. Thirty-six percent of the patients had regional lymph node metastasis and exhibited a strong association with younger age, substance abuse, higher tumor size, tongue as a site, moderate-to-poor tumor differentiation, low tumor-infiltrating lymphocytes, and higher perineural and lymphovascular invasion. Moreover, at the end of the two-year survival analysis, 34% of patients succumbed to the disease. Overall survival was observed to be significantly better with <2 cm maximum tumor size, well-differentiated tumor morphology, higher tumor-infiltrating lymphocytes, and no nodal metastasis. Conclusions: The study highlights the intricate correlations of various histopathological factors in OSCC, shedding light on their potential implications for prognosis.

show abstract

Section: Discussioncontrasting

confidence: 99%

A Study of Histological and Clinical Parameters and Their Correlation With Lymph Node Metastasis and Two-Year Survival in 50 Cases of Oral Squamous Cell Carcinoma

Singh,

Somani,

Poduwal

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…According to data from 970 patients, the floor of the mouth, soft palate, gingiva, buccal mucosa, and hard palate were the sites with the highest prevalence of OSCC, accounting for around 50% of all the cases [17].…”

Section: Discussionmentioning

confidence: 99%

A Concordance Between Clinical and Pathological Tumor Staging of Oral Squamous Cell Carcinoma: An Institutional Study

Ramalingam,

Ramani

et al. 2024

Cureus

View full text Add to dashboard Cite

Background: Among oral diseases, oral cancer is the primary cause of death and poses a serious health risk. Primary tumor (T) -regional lymph node (N) -distant metastasis (M) comprising (TNM) staging is crucial for planning treatment strategies for patients with oral squamous cell carcinoma (OSCC).Aim: This study evaluated the predictive accuracy of clinical TNM staging of OSCC to histopathological staging (pTNM) in an institutional setting.Materials and methods: Fifty-four consecutive histologically confirmed, surgically treated OSCC cases were evaluated for TNM staging. The study compared the clinical staging at the time of surgery with the pathological staging obtained from excisional biopsy reports. Microsoft Excel (Microsoft® Corp., Redmond, WA, USA) was used for the data compilation and descriptive analysis. The chi-square test, analysis of variance (ANOVA), and Tukey's Honest Significant Difference (HSD) posthoc test were used to compare the data for statistical significance with p value <0.05 using Statistical Package for the Social Sciences (IBM SPSS Statistics for Windows, IBM Corp., Version 23.0, Armonk, NY).Results: The alveolar mucosa (n=22, 40.74%) was the most frequently occurring site, followed by the tongue (n=17, 31.48%). Out of the 54 included cases, based on clinical tumor size, there were T1 (n=6), T2 (n=13), T3 (n=13), T4a (n=16) and T4b (n=6). T2 tumors were usually upstaged (n=7) while T4a (n=8) tumors were most often downstaged. T4a (n=8) had the best concordance between clinical and histopathological staging, followed by T2, T3, and T1. In nodal status, N1 showed the most variation. The chi-squared test showed statistical significance for tumor size comparison (p <0.001) and nodal status comparison (p=0.002). ANOVA test did not show any statistical significance. Tukey's HSD posthoc test showed statistical significance (p=0.034) for N0 and N1 status. The highest concordance was shown by N0 and N1 followed by N2b.Conclusion: Preoperative radiological and clinical assessments are essential for deciding on a patient's course of treatment. However, not all patients may require radiographs to determine tumor size or nodal status assessment. Accurate diagnosis is vital for the treatment planning of OSCC.

show abstract

“…11 Large-sample studies have consistently shown that regular consumption of vegetables, citrus fruits, sh, and vegetable oils is the main feature of a low-risk diet for oral cancer, after adjusting for smoking and alcohol intake. 12 Patients and medical staff having greater awareness of the risk factors for oral cancer can lead to early diagnosis, which in turn will help improve the survival of oral cancer patients to the greatest extent. Moreover, there is a lack of research on the risk factors for oral cancer in young people.…”

Section: Discussionmentioning

confidence: 99%

Association of exposure factors and their causal relationship with oral cancer: A Mendelian randomization study

Li,

Wang,

et al. 2023

Preprint

View full text Add to dashboard Cite

Objectives There is a strong association among risk factors for oral cancer (ORCA), such as smoking, alcohol consumption, fiber intake, and red meat intake. The apparent synergistic effects reported in previous observational studies may also underestimate the independent effects.Our study aims to further explore the potential etiology and causality of oral cancer. Materials and Methods This study used the genome-wide association studies database (GWAS) for Mendelian randomization (MR) analysis to explore exposure factors associated with ORCA and detect the genetic causality between these exposures and ORCA risk. Results Our results demonstrated that in univariate MR analysis, the five exposure factors (celery intake, average weekly beer and cider intake, spirits intake, and pork intake) were risk factors, and oily fish intake was a safety factor, but in multivariate MR analysis, pork intake had the greatest impact on oral cancer when the five food/drink intakes were simultaneously consumed. Conclusions The causal relationship between the five exposure factors (oily fish intake, celery intake, pork intake, average weekly beer and cider intake, and spirits intake) and oral cancer was analyzed. The causal effects of pork on oral cancer may be underestimated. Clinical Relevance Prevention of oral cancer requires better education about lifestyle-related risk factors, and improved awareness and tools for early diagnosis. Our study provides some risk factors that cannot be ignored for the cause prevention of oral cancer, such as pork intake, and its role in oral cancer prevention and control.

show abstract

Characteristics of oral squamous cell carcinoma focusing on cases unaffected by smoking and drinking: A multicenter retrospective study

Cited by 8 publications

References 45 publications

A Study of Histological and Clinical Parameters and Their Correlation With Lymph Node Metastasis and Two-Year Survival in 50 Cases of Oral Squamous Cell Carcinoma

A Study of Histological and Clinical Parameters and Their Correlation With Lymph Node Metastasis and Two-Year Survival in 50 Cases of Oral Squamous Cell Carcinoma

A Concordance Between Clinical and Pathological Tumor Staging of Oral Squamous Cell Carcinoma: An Institutional Study

Association of exposure factors and their causal relationship with oral cancer: A Mendelian randomization study

Contact Info

Product

Resources

About