Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China

Li, Hezi; Luo, Zhilin; Zhang, Hong; Huang, Nali; Li, Dong; Luo, Chengjuan; Wang, Tianhu

doi:10.1155/2021/2259093

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…This systematic review obtained 19 studies examining the oral microbiota in oral cancer. The studies were conducted in 10 Asian countries, 8,[18][19][20][21][22][23][24][25] two studies in Australia, 14,26 and six studies in United States of America (USA), 9,[27][28][29] and two studies in Europe. 30,31 The types of studies used were cohort (n=6) and cross-sectional (n=14).…”

Section: Resultsmentioning

confidence: 99%

Oral microbiota in oral cancer patients and healthy individuals: A scoping review

Sufiawati

Piliang²,

Ramamoorthy³

2022

Dent. J. (Majalah Kedokt. Gigi)

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Background: Oral microbiota has been suggested to have a role in the etiopathogenesis of oral cancer; however, the oral microbiota diversity in patients with oral cancer compared to healthy individuals remains unclear. Purpose: This scoping review aimed to provide an overview of the current evidence regarding the oral microbiota composition colonized in oral cancer patients and its comparison with healthy individuals. Reviews: This study was conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Eligible studies were searched in PubMed, Scopus, Web of Science, and ScienceDirect databases from January 2015 to March 2022. A total of 20 relevant studies were included according to the inclusion and exclusion criteria, including 14 cross-sectional studies and 6 cohort studies. All studies have identified various oral bacteria, but only one study has detected viruses and parasites diversity. A variety of oral microbiota found were 6 phyla of bacteria, 6 phyla of viruses, 7 phyla of fungi, and 7 phyla of parasitic. Seventeen studies proved that oral microbiota compositions were statistically significant differences compared to healthy controls, but not in 3 studies. Conclusion: The majority of studies showed various oral bacteria in oral cancer patients which were statistically significant difference compared to healthy controls. This study indicates the need for more research to evaluate viruses and parasites composition and diversity in oral cancer patients. Moreover, future research should focus to clarify whether the changes of oral microbial composition as a community may play a critical role in the etiopathogenesis of oral cancer.

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Section: Resultsmentioning

confidence: 99%

Oral microbiota in oral cancer patients and healthy individuals: A scoping review

Sufiawati

Piliang²,

Ramamoorthy³

2022

Dent. J. (Majalah Kedokt. Gigi)

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“…In the current study, we found that Firmicutes and Streptococcus were significantly increased while Lactobacillales and Pasteurellaceae were significantly decreased in oral cavity of HIV patients with KSHV oral shedding. Additional studies demonstrated higher abundances of Streptococcus in the salivary microbiome of several oral cancers or head and neck cancers, including salivary adenoid cystic carcinoma (SACC), oral squamous cell carcinoma (OSCC), and esophageal squamous cell carcinoma (ESCC; Jiang et al, 2021 ; Li et al, 2021 ; Stasiewicz and Karpinski, 2021 ). Thus, these data indicate potential contribution of Streptococcus to different oral cancers development.…”

Section: Discussionmentioning

confidence: 99%

Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients

Dai

Chen

et al. 2022

Front. Microbiol.

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Kaposi’s Sarcoma (KS) caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) continues to be the most common AIDS-associated tumor. Involvement of the oral cavity represents one of the most common clinical manifestations of this tumor. Numerous types of cancer are associated with the alterations of in components of the microbiome. However, little is known about how KSHV coinfection affects the oral microbiome in HIV+ patients, especially in a “pre-cancer” niche. Using 16S rRNA pyrosequencing, we found that oral shedding of KSHV correlated with altered oral microbiome signatures in HIV+ patients, including a reduction in the microbiota diversity, changing the relative composition of specific phyla and species, and regulating microbial functions. Furthermore, we found that Streptococcus sp., one of the most increased species in the oral cavity of HIV+/KSHV+ patients, induced KSHV lytic reactivation in primary oral cells. Together, these data indicate that oral shedding of KSHV may manipulate the oral microbiome to promote viral pathogenesis and tumorigenesis especially in immunocompromised patients.

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“…Apart from the effects of the above mentioned pathogens, other experiments showed different possibilities of the influence of the oral microbiota. A study on about oral microbiota in patients with esophageal cancer was conducted by Hezi Li et al (Li H et al, 2021). In this study, microbiota analysis was performed by sequencing the 16S rRNA of V3-V4 gene regions.…”

Section: Alterations In the Oral Microbiotamentioning

confidence: 99%

“…A study on about oral microbiota in patients with esophageal cancer was conducted by Hezi Li et al. ( Li H et al., 2021 ). In this study, microbiota analysis was performed by sequencing the 16S rRNA of V3-V4 gene regions.…”

Section: Alterations In the Oral Microbiotamentioning

confidence: 99%

“…At the phylum level, patients with OSCC had a reduced amount of Proteobacteria (17.0% vs 20.1% in healthy controls), however slightly higher levels of Bacteroidetes (25.3% vs 24.9%) and Firmicutes (34% vs 31.1%). At the genus level, the difference between OSCC patients and healthy control subjects is seen in Streptococcus (17.3% vs 14.5%), Prevotella (8.6% vs 8.5%) and Neisseria (8.1% vs 10.7%) ( Li H et al., 2021 ).…”

Section: Alterations In the Oral Microbiotamentioning

confidence: 99%

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Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view

Muszyński

Kudra

Sobocki

et al. 2022

Front. Cell. Infect. Microbiol.

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There is an urgent need to search for new screening methods that allow early detection of esophageal cancer and thus achieve better clinical outcomes. Nowadays, it is known that the esophagus is not a sterile part of the gastrointestinal tract. It is colonized with various microorganisms therefore a “healthy” esophageal microbiome exists. The dysbiotic changes of esophageal microbiome can lead to the development of esophageal diseases including esophageal cancer. There is a strong consensus in the literature that the intestinal microbiome may be involved in esophageal carcinogenesis. Recently, emphasis has also been placed on the relationship between the oral microbiome and the occurrence of esophageal cancer. According to recent studies, some of the bacteria present in the oral cavity, such as Tannerella forsythia, Streptococcus anginosus, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum may contribute to the development of this cancer. Moreover, the oral microbiome of patients with esophageal cancer differs significantly from that of healthy individuals. This opens new insights into the search for a microbiome-associated marker for early identification of patients at high risk for developing this cancer.

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Characteristics of Oral Microbiota in Patients with Esophageal Cancer in China

Cited by 9 publications

References 37 publications

Oral microbiota in oral cancer patients and healthy individuals: A scoping review

Oral microbiota in oral cancer patients and healthy individuals: A scoping review

Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients

Esophageal cancer and bacterial part of gut microbiota – A multidisciplinary point of view

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