Characteristics of object location memory in mice: Behavioral and pharmacological studies

Murai, Takeshi; Okuda, Suguru; Tanaka, Takeshi; Ohta, Hisashi

doi:10.1016/j.physbeh.2006.09.013

Cited by 178 publications

(137 citation statements)

References 42 publications

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“…The T-maze spontaneous alternation task (T-SAT), novel object recognition task (NORT) (13), object location task (OLT) (94), and passive avoidance paradigm (38) were used to analyze hippocampal-dependent memory. Plus maze and light-dark tests (38) were used to analyze anxiety-like behaviors, while accelerating rotarod (95) was used to analyze motor learning.…”

Section: Discussionmentioning

confidence: 99%

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

Brito¹,

Giralt²,

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

Brito¹,

Giralt²,

et al. 2014

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“…Lines of evidence indicate that normal rodents spend more time exploring an object placed in a novel location than in a familiar location in an object location test. Moreover, their performance in the test trial is relevant to spatial cognitive memory attributable to the hippocampus system involved in detecting spatial novelty (20,23,24). In the test phase trial, shamoperated control animals showed a higher preference for an object placed in a novel location than for an object placed in a familiar location, whereas the vehicle-treated P2VO mice were unable to discriminate the object placed in a novel location.…”

Section: Discussionmentioning

confidence: 99%

“…These findings raise the possibility that facilitation of central cholinergic systems induced by CTS involves different mechanism(s) from those induced by THA and lead us to infer that cholinesterase inhibition is not always the mechanism responsible for the beneficial effect of CTS on P2VO-induced cognitive deficits in mice. However, further investigations using hippocampal tissues as an enzyme source may be required to more thoroughly answer questions concerning involvement of cholinesterase inhibition in the effects of CTS since cholinergic hypofunction impairs spatial cognitive behavior in which the hippocampus plays an important role (24,25,32).…”

Section: Discussionmentioning

confidence: 99%

Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice

et al. 2007

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Abstract. We previously demonstrated that the Kampo formula chotosan (CTS) ameliorated spatial cognitive impairment via central cholinergic systems in a chronic cerebral hypoperfusion (P2VO) mouse model. In this study, the object discrimination tasks were used to determine if the ameliorative effects of CTS on P2VO-induced cognitive deficits are a characteristic pharmacological profile of this formula, with the aim of clarifying the mechanisms by which CTS enhances central cholinergic function in P2VO mice. The cholinesterase inhibitor tacrine (THA) and Kampo formula saikokeishito (SKT) were used as controls. P2VO impaired object discrimination performance in the object recognition, location, and context tests. Daily administration of CTS (750 mg / kg, p.o.) and THA (2.5 mg / kg, i.p.) improved the object discrimination deficits, whereas SKT (750 mg / kg, p.o.) did not. In ex vivo assays, tacrine but not CTS or SKT inhibited cortical cholinesterase activity. P2VO reduced the mRNA expression of m 3 and m 5 muscarinic receptors and choline acetyltransferase but not that of other muscarinic receptor subtypes in the cerebral cortex. Daily administration of CTS and THA but not SKT reversed these expression changes. These results suggest that CTS and THA improve P2VO-induced cognitive impairment by normalizing the deficit of central cholinergic systems and that the beneficial effect on P2VO-induced cognitive deficits is a distinctive pharmacological characteristic of CTS.

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“…The object location and object recognition tests were performed as reported with slight modifications [7,8]. Both tests consisted of three phases: habituation, acquisition, and retention (30 min after the acquisition phase) conducted within a polycarbonate cage (35 × 35 × 35 cm) under illumination of 25 lux.…”

Section: Behavioral Testmentioning

confidence: 99%

“…The object location test is based on the spontaneous tendency of rodents to explore an object placed in a novel location for a longer period of time than that of a non-displaced identical object or more frequently than that of a familiar one [7,8]. Both tests have been used to evaluate memory without the need for conventional reinforcers.…”

Section: Introductionmentioning

confidence: 99%

Effects of a Cav2.2 inhibitor on spatial and non-spatial short-term memory

Zhao¹,

Niimi²,

Li³

et al. 2015

Integr Mol Med

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Neuronal voltage-gated calcium channels (VGCCs), including Cav2.1 and Cav2.2, mediate the presynaptic machinery responsible for vesicular release of neurotransmitters. However, the role of different VGCCs in neural circuits underlying spatial and non-spatial short-term memory remains poorly understood. Previous report has shown that Cav2.1-mediated signaling is required on spatial memory in a hippocampus-related object location test but has little effect on nonspatial memory in a perirhinal cortex-related object recognition test. Thus, Cav2.2-mediated functions need to be clarified. This study examined whether Cav2.2-mediated signaling plays a role in spatial and non-spatial short-term memory. Intracerebroventricular injection of the Cav2.2 inhibitor ω-conotoxin GVIA (5 pg/ side) in mice resulted in deficits in object location and recognition tests indicative of short-term memory. These results indicate that different VGCCs have different effects on memory performance.

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Characteristics of object location memory in mice: Behavioral and pharmacological studies

Cited by 178 publications

References 42 publications

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice

Effects of a Cav2.2 inhibitor on spatial and non-spatial short-term memory

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