Characteristics of Neuromuscular Blockade Produced by Gallamine, Pancuronium and Vecuronium (Org Nc-45), and Antagonism With Neostigmine in Anaesthetized Horses

Reversal of neuromuscular block in companion animals

“…Further publications appeared on the use of neostigmine in the dog (Jones ) and in the horse (Klein et al. ) and also on the use of edrophonium in the dog (Clutton ) and the horse (Hildebrand & Howitt ).…”

“…It was some 24 years later that the first review on the reversal of NMB in animals was published (Jones 1988). Further publications appeared on the use of neostigmine in the dog (Jones 1990) and in the horse (Klein et al 1982) and also on the use of edrophonium in the dog (Clutton 1994) and the horse (Hildebrand & Howitt 1984).…”

Prolonged neuromuscular blockade in a horse following concomitant use of vecuronium and atracurium

“…In a vecuronium dose finding study in horses a 20% depression of initial twitch height was seen using 0.06 mg kg −1 (Klein et al. 1981).…”

“…In a vecuronium dose finding study in horses a 20% depression of initial twitch height was seen using 0.06 mg kg )1 (Klein et al 1981). However, vecuronium (0.1 mg kg )1 ) failed to produce a 50% block in two and no response in one of eight ponies (Bardell et al 2010).…”

Observations of the potency and duration of vecuronium in isoflurane-anesthetized horses

“…When the supply of atracurium to our institution was interrupted, we investigated vecuronium as an alternative neuromuscular blocking agent (NMBA) for horses. Although this drug has been used in horses (Klein et al. 1982; Fantoni et al.…”