Characteristics of neonatal Sepsis at a tertiary care hospital in Saudi Arabia

Al-Matary, Abdulrahman; Heena, Humariya; AlSarheed, Ayah Sulaiman; Ouda, Wafa; Alshahrani, Dayel; Wani, Tariq Ahmad; Qaraqei, Mostafa; Abu-Shaheen, Amani

doi:10.1016/j.jiph.2019.03.007

Cited by 31 publications

(39 citation statements)

References 20 publications

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“…Similar to the current publication this same report indicated that all Gram-negative organisms isolated were sensitive to amikacin. 33 It has previously been reported that the carriage of the bla SHV -related genes may be universal in K. pneumoniae isolates, 34 while three K. pneumoniae isolates from our collection were repeatedly SHV negative using PCR. Various technical issues (DNA extraction, PCR thermocycling, etc.)…”

Section: Discussionmentioning

confidence: 58%

CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha’il, Saudi Arabia

Al-Mogbel

Altheban

Alenezi³

et al. 2021

IDR

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Objective The aim of this study was to retrospectively characterize E. coli and K. pneumoniae isolates obtained from neonates during a suspected NICU outbreak of infection in Ha’il, Saudi Arabia during a period of one month (April 2014). Methods Antibiotic susceptibility patterns, molecular characterization for antibiotic-resistant genes ( bla TEM, bla SHV, and bla CTX-M), and genotyping by PFGE and MLST were performed. Results A total of 24 E. coli and 48 K. pneumoniae isolates were cultured from neonates that had been admitted to the NICU. Among E. coli , the majority of isolates (19/24) were ESBL-positive and all of these nineteen (100%) harbored the CTX-M-15 gene. A total of 15% (3/19) were co-producers of CTX-M-15 and SHV-12, and 68.4% (13/19) were co-producers of CTX-M-15 and TEM-1. Among K. pneumoniae isolates, 87.5% (42/48) were ESBL positive with 92.85% (39/42) of these isolates containing the CTX-M-15 gene. A total of 97% (38/39) of K. pneumoniae were co-producers of CTX-M-15 and SHV-12, and 88% (37/42) were positive for TEM-1. Furthermore, 85.7% (36/42) K. pneumoniae were co-producers of CTX-M-15 and TEM-1. The majority of E. coli isolates (18/19 isolates) were grouped into two genetic clusters by pulsed field gel electrophoresis (PFGE) and all the isolates were found to be ST-131 type. In contrast, K. pneumoniae (31/42) isolates belonged to a single genotypic lineage, and all (100%) isolates belonged to the ST-14 type. Conclusion This is the first report of CTX-M-15-positive, ESBL E. coli , and K. pneumoniae isolates recovered from an outbreak in an NICU in Ha’il, Saudi Arabia. It is alarming to note the high rate of outbreak isolates with simultaneous production of CTX-M-15 and SHV-12 conferring high-level resistance to oxyimino-cephalosporins.

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Section: Discussionmentioning

confidence: 58%

CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha’il, Saudi Arabia

Al-Mogbel

Altheban

Alenezi³

et al. 2021

IDR

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“…In the research results of Gutbir et al it is stated that an Apgar score with a low score is at risk of experiencing neonatal sepsis with a relative risk of 1.28, in line with the results of research from 9 literatures discussing Apgar scores with a low score can be 3 times greater risk to suffer from neonatal sepsis (p value<0.05, 95% CI: 1.3-7-7, OR: 3.2). 1,[9][10][11][12][13][14][15][16] Assessment of the Apgar score can be done at the same time as the examination of sex, gender is one of the risk factors for neonatal sepsis. The gender at risk for infection is higher in the male sex, this is in accordance with the results of the study of Murthy, et al that male infants are 1.3 times higher risk of infection (p value=0.03, 95% CI: 1.02-1.68, OR: 1.3) compared to female infants, this is in line with the results of 5 literature studies which state that male sex is at risk 1.31 (p value=0.003, 95% CI: 1.22-1.41, OR: 1.31) had a higher risk of infection and even death than women.…”

Section: Resultsmentioning

confidence: 99%

The relationship between Apgar score and gender with the incidence of neonatal sepsis: systematic review

Lidya

Fetriyah

Rahmayani

et al. 2021

Int J Community Med Public Health

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Neonatal sepsis is a cause of mordibity and mortality in newborns that causes long-term complications that can lead to death. One of risk factors for neonatal sepsis in infants is the Apgar score and gender. The aim of the study was to analyze the relationship between Apgar score and gender with the incidence of neonatal sepsis. This study was systematic review, in searching sourced from six databases (EBSCO, Clinicalkey Nursing, PubMed, ProQuest, Science Direct and Springer Link). In searching for studies using the PICOS framework, the selection study used The Joanna Brigss Guideline Critical Appraisal. The literature used was 14 studies. The results of this study were from 14 literatures used, the average total incidence of neonatal sepsis was 0.356 (35.6%).10 of the 14 literatures stated that the 5th minute Apgar score of less than seven (<7) could be an independent predictor of the risk of neonatal sepsis with a mean risk of 16.9% (p value<0.01) and there were 8 from 14 literatures which states that there is a significant relationship between gender and the incidence of male gender morbidity with a risk of 1.02 (p value=0.00). The results showed that there was a relationship between Apgar scores and gender with the incidence of neonatal sepsis. Therefore, nurses or birth attendants need to be vigilant and take preventive measures if they find babies have Apgar scores and male sex as signs of a possible higher risk of neonatal sepsis in newborns.

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“…detected an association between low birth weight and preterm delivery and the risk of infection including EOS, which is similar to our findings. 13 Finally, a study by Abutaleb et al., which reviewed the medical records of neonates diagnosed with neonatal sepsis in 2016 in King Khalid University Hospital in Riyadh, reported that 92 neonates were diagnosed with neonatal sepsis. Of these, 68 neonates (73%) were classified as EOS.…”

Section: Discussionmentioning

confidence: 99%

“…12 Finally, a recent publication reporting neonatal sepsis in King Fahad Medical City in Riyadh via the retrospective assessment of medical records between 2011 and 2015 revealed that among the EOS cases, most causative organisms were Group B streptococcus and Escherichia coli . 13 …”

Section: Introductionmentioning

confidence: 99%

Epidemiology and risk factors associated with early onset neonatal sepsis in the south of KSA

Almudeer

Alibrahim

Gosadi

2020

Journal of Taibah University Medical Sciences

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Objectives This study aims to describe the epidemiology of early onset sepsis (EOS) and its associated risk factors in a tertiary healthcare centre in the south of KSA. Methods We conducted a retrospective review of the medical records of neonates diagnosed with EOS at King Fahad Central Hospital (KFCH), Jazan, KSA. Data on the incidence, causative organisms, and related risk factors for EOS were collected. Results The incidence of EOS in our sample was 4.44 per 1,000 live births during the study period. The most frequently isolated organisms from neonates were E. coli (29%), Group B streptococcus (GBS) (17%), and coagulase-negative Staphylococcus (11%). The gestational age and weight at birth of neonates who died within a week compared to those who survived were statistically different ( p values < 0.05). Finally, the percentage of neonates found to be infected with E. coli was higher among neonates with either an extremely low birth weight or very low birth weight ( p = 0.016). Conclusions Our study shows a higher incidence of EOS in KFCH in the Jazan region compared to similar clinical settings in KSA. Identifying pre-term birth weight and low birth weight as possible risk factors of early mortality of infants with EOS may necessitate the need for reassessment of antenatal care services in the region.

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Characteristics of neonatal Sepsis at a tertiary care hospital in Saudi Arabia

Cited by 31 publications

References 20 publications

CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha’il, Saudi Arabia

CTX-M-15 Positive Escherichia coli and Klebsiella pneumoniae Outbreak in the Neonatal Intensive Care Unit of a Maternity Hospital in Ha’il, Saudi Arabia

The relationship between Apgar score and gender with the incidence of neonatal sepsis: systematic review

Epidemiology and risk factors associated with early onset neonatal sepsis in the south of KSA

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