Characteristics of multiple basal cell carcinomas: The first study on Japanese patients

Abstract

Basal cell carcinoma (BCC), the most frequent skin cancer, has been increasing in incidence. However, the characteristics of multiple BCC have not been clarified in Japan. Therefore, we conducted a retrospective study to elucidate the features of multiple BCC compared with solitary BCC. The study population consisted of 327 patients with histopathologically proven BCC who were referred to the Department of Dermatology in Tottori University Hospital between November 2006 and April 2016. Of the 327 patients, 304 (93.0%) had solitary BCC and 23 (7.0%) had multiple BCC. The mean age of the patients with solitary BCC was 74.7 years (range, 31-102) and that of patients with multiple BCC was 79.3 years (range, 63-91). There was a significant difference in mean age between the two groups (P = 0.01). Approximately four-fifths of the BCC were located on the head or neck in the total study population. In the group of patients with multiple BCC, the incidence of lesions on the head and neck was lower and that on the trunk was higher than those in patients with solitary BCC. There was a significant difference in the tumor site between the two groups (P < 0.0001). With respect to tumor histopathology, the ratio of superficial BCC was significantly higher in the group of patients with multiple BCC than in the group of patients with solitary BCC (P < 0.0001). In conclusion, we demonstrated that older age, truncal location and superficial histopathological type of tumor are features of multiple BCC in Japanese subjects.

Novel Insights for Patients with Multiple Basal Cell Carcinomas and Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology, and Dermatoscopy

“…In our study, we observed that older patients at a slightly higher male/female ratio comprised the group of mBCC as compared with the sBCC group (Table 2). This finding was in accordance with the previously published literature [8,9,22]. The distribution of histological subtypes of the tumor in both groups was similar and corresponded to the average of the incidence of various forms of the neoplasm [1] (Table S2).…”

“…Multiple BCC patient risk factors (e.g., sex, age, etc.) have been investigated in the literature [7][8][9][10]. Further studies on the clinical features of multiple tumors and patients' profiling could provide physicians with important knowledge towards prevention of this neoplasm.…”

A Five-Year Retrospective Analysis of Basal Cell Carcinoma: A Monocentric Study

“…Van Lersel et al 12 and Ramachandran et al 13 reported that males older than 60 years old were at an increased risk of multiple BCCs. Adachi et al 2 compared clinicopathological data in a study of 327 cases with solitary and multiple tumors. No gender variation was found between the two groups, but there was a statistically significant difference in the incidence rate of multiple BCCs in our study, occurring more frequently in males and older patients.…”

“…Basal cell carcinoma (BCC) is the most common type of cancer worldwide, and its occurrence is inversely related to a country’s geographical latitude 1 . BCC is most frequently seen in light-skinned people, generally as a solitary lesion, although it can also develop as multiple lesions 2 . The risk of different tumor formations is high in patients with two or more BCCs 1 .…”

Multiple Development of Basal Cell Carcinoma of the Skin – a Comprehensive Review

“…According to the literature data, the percentage of patients with more than 1 primary BCC lesion has varied from 7% to 46% [3,[6][7][8][9][10][11][12][13] and the mean number of tumors per individual has ranged from 1.5 to 1.9. [11,14] This variability may be explained by several factors, such as the total number of participants, distinct ethnicity, different follow-up periods, and misclassification bias.…”