Characteristics of motor speech phenotypes in multiple sclerosis

Rusz, Ján; Beňová, Barbora; Růžičková, Hana; Novotný, Michal; Tykalová, Tereza; Hlavnička, Jan; Uher, Tomáš; Vaněčková, Manuela; Andělová, Michaela; Novotná, Klára; Kadrnozkova, Lucie; Horáková, Dana

doi:10.1016/j.msard.2017.11.007

Cited by 63 publications

(52 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This correlation was found in MS but not in healthy controls (24) and was corroborated by similar findings between NPT and speech intelligibility (19), speech rate (total output per time) (24,43) and articulatory rate (i.e. length of phonemes) (24,31). Time and frequency of pauses may have a stronger correlation than articulatory rate (24,63).…”

Section: Dysarthria and Cognitionsupporting

confidence: 58%

“…and confirmed in objective measurementsmeans of 11% and 24% less syllables per second(32,43) and around 14% less words per minute(20,31) were produced by PwMS in comparison to…”

supporting

confidence: 61%

“…Longer duration of syllables was observed in different tasks including spontaneous speech, reading and syllable repetition(7, 8, 24, 29- 31). Additionally, results from acoustic analysis showed an inverse moderate correlation between articulation rate and overall disability (EDSS, r=0.5, p<0.001), hand dexterity (9 peg hole test, r=0.54, p<0.001), and walking speed (timed 25-foot walk, r=0.41, p<0.001)(31).Tongue movements are particularly affected in PwMS and can be detected even before overt dysarthria manifests. Studies that utilized acoustic analysis showed, through investigation of the maximum slope of the second formant (F2), that phoneme transitions requiring fast tongue or fast pharyngeal movements were slower in dysarthric PwMS…”

mentioning

confidence: 95%

See 2 more Smart Citations

What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

Noffs

Perera

Kolbe

et al. 2018

Autoimmunity Reviews

View full text Add to dashboard Cite

IMPORTANCE: Multiple sclerosis produces neurological impairments that are variable in duration, severity and quality. Speech is frequently impaired, resulting in decreased communication skills and quality of life. Advancements in technology now makes it possible to use quantitative acoustic assessment of speech as biomarkers of disease progression. OBSERVATIONS: Four domains of speech have been identified: articulation (slow articulation and imprecise consonants), voice (pitch and loudness instability), respiration (decreased phonatory time and expiratory pressure) and prosody (longer and frequent pauses, deficient loudness control). Studies also explored predictive models for diagnosis of MS and ataxia through speech assessment, the relationship of dysarthria with cognition and very few studies correlated neuroimaging with dysarthria. We could not identify longitudinal studies of speech or dysarthria in Multiple Sclerosis. CONCLUSION AND RELEVANCE: Refinement of objective measures of speech has enhanced our understanding of Multiple Sclerosis-related deficits in cross-sectional analysis while both integrative and longitudinal studies are identified as major gaps. This review highlights the potential for using quantitative acoustic assessments as clinical endpoints for diagnosing, monitoring progression and treatment in disease modifying trials.

show abstract

Section: Dysarthria and Cognitionsupporting

confidence: 58%

“…and confirmed in objective measurementsmeans of 11% and 24% less syllables per second(32,43) and around 14% less words per minute(20,31) were produced by PwMS in comparison to…”

supporting

confidence: 61%

mentioning

confidence: 95%

See 1 more Smart Citation

What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

Noffs

Perera

Kolbe

et al. 2018

Autoimmunity Reviews

View full text Add to dashboard Cite

show abstract

“…Speech disorders in patient with MS may be investigated with perceptual, acoustic, aerodynamic, and physiological assessments though computer or laboratory-based practices 114 . Specifically, voice characteristic can be evaluated with the Multi-Dimensional Voice Program (MDVP) 115 , electroglottography 116 and videostroboscopy 117 .…”

Section: Speech Disordersmentioning

confidence: 99%

Otolaryngologic Symptoms in Multiple Sclerosis: A Review

Ralli¹,

Stadio²,

Visconti³

et al. 2018

The International Tinnitus Journal

View full text Add to dashboard Cite

Many symptoms of multiple sclerosis may affect the ear, nose and throat. The most common otolaryngologic symptoms of multiple sclerosis are speech disorders, followed by sleep disorders, vertigo and disequilibrium, dysphagia, smell alterations, and hearing loss. Less common symptoms include sialorrhea, facial palsy, taste alterations, trigeminal neuralgia and tinnitus. The origin of otolaryngologic symptoms in multiple sclerosis is mainly central, although increasing evidence also suggests a peripheral involvement.

show abstract

“…However, individuals with MS can develop virtually any type of dysarthria depending on disease-related lesion locations 3 . The most common speech characteristics of persons with dysarthria due to MS (PwDMS) are imprecise articulation and deviant prosodic stress patterns, which are often the result of a slowed speech rate, phoneme prolongations, and impaired loudness control 1,2,5 . A harsh or strained/strangled voice and abnormal pitch levels can also be observed 1,2,5 .…”

Section: Introductionmentioning

confidence: 99%

A first investigation of tongue, lip, and jaw movements in persons with dysarthria due to multiple sclerosis

Mefferd¹,

Lai²,

Bagnato

2019

Multiple Sclerosis and Related Disorders

View full text Add to dashboard Cite

Background: Multiple sclerosis can affect the speech motor system and result in dysarthria. Objectives: This pilot study sought to identify tongue, lip, and jaw motor deficits in persons with dysarthria due to multiple sclerosis (PwDMS) to better understand the speech motor mechanisms that underlie their aberrant speech. Methods: Tongue and jaw movements during /ai/ and lower lip and jaw movements during /bob/ were examined in eleven PwDMS and fourteen age- and sex-matched controls using threedimensional electromagnetic articulography. Movement duration, maximum displacement, peak speed, stiffness (i.e., peak speed/displacement ratio), and jaw contribution to lower lip and tongue displacements were of particular interest. Results: Whereas most kinematic measures yielded significant between-group differences for tongue and jaw motor performance during /ai/, lower lip and jaw motor performance during /bob/ were mostly comparable between groups. Conclusion: Findings suggest that speech movements of the tongue are differentially more impaired than those of the lower lip in PwDMS. Particularly the ability to move the tongue with adequate speed during speech was significantly impaired in PwDMS, which may explain, in part, their slowed speech rate. Aberrant jaw kinematics during /ai/ may be a compensatory strategy to maximize speech clarity in the presence of the impaired tongue motor performance.

show abstract

Characteristics of motor speech phenotypes in multiple sclerosis

Cited by 63 publications

References 29 publications

What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

Otolaryngologic Symptoms in Multiple Sclerosis: A Review

A first investigation of tongue, lip, and jaw movements in persons with dysarthria due to multiple sclerosis

Contact Info

Product

Resources

About