Characteristics of minute T1 colorectal cancer in relevance to pathology and treatment

Park, Sin Hye; Oh, Seon Ok; Roh, Seung Jae; Han, Kyung Su; Kim, Bun; Hong, Chang Won; Kim, Jae Hak; Sohn, Dae Kyung; Chang, Hee Jin; Park, Sung Chan; Oh, Jae Hwan

doi:10.4174/astr.2020.98.4.199

Cited by 4 publications

(6 citation statements)

References 21 publications

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“…In Park et al [38] research in CRC, they suggest TOMM20 as a potential therapeutic target of CRC. Yang et al [39] found overexperssion of TOMM20 which impacted liver cancer prognosis.…”

Section: Resultsmentioning

confidence: 99%

To Explore Genes Related to the Prognosis of Colorectal Cancer

Chen¹,

Tan²,

Yin³

et al. 2023

IJPS

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To explore the genes correlated with the prognosis in colorectal cancer is the main objective of the study. Identification of differential genes through series of GSE20970, GSE37182, GSE44861 and GSE64392 from gene expression Omnibus database and then the differential genes were analyzed by gene ontology and Kyoto encyclopedia of genes and genomes enrichment. Through protein-protein interaction networks, screening of key genes was done and then we analyzed the prognosis of colorectal cancer from the cancer genome Atlas database. We obtained the differential genes through limma screening in series data GSE20970, GSE37182, GSE44861 and GSE64392 from gene expression Omnibus database. Venn diagram was used to screen 206 intersecting differentially expressed genes. Gene ontology enrichment analysis terms used were cytosol, transcription, deoxyribonucleic acid-templated, nucleic acid-templated transcription, ribonucleic acid biosynthetic process, nucleobase-containing compound biosynthetic process, heterocycle biosynthetic process, aromatic compound biosynthetic process, regulation of nucleobase-containing compound metabolic process, regulation of ribonucleic acid metabolic process, organic cyclic compound biosynthetic process. Kyoto encyclopedia of genes and genomes pathway terms were interleukin-17 signaling pathway, bladder cancer, phospholipase D signaling pathway, human cytomegalovirus infection, aldosterone-regulated sodium reabsorption, Kaposi's sarcoma-associated herpesvirus infection, forkhead box O signaling pathway, nuclear factor kappa B signaling pathway, hepatitis B. Protein-protein interaction network has shown 206 key genes. According to the top 50 of betweenness value, we analyzed the prognosis of colorectal cancer from the cancer genome Atlas database. We found Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, C-X-C motif chemokine ligand 8, partner and localizer of breast cancer gene 2, peroxiredoxin 4 and translocase of outer mitochondrial membrane 20 are the key genes which impact prognosis in colorectal cancer. We predict that these genes can promote the survival time of colorectal cancer in future.

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“…In Park et al [38] research in CRC, they suggest TOMM20 as a potential therapeutic target of CRC. Yang et al [39] found overexperssion of TOMM20 which impacted liver cancer prognosis.…”

Section: Resultsmentioning

confidence: 99%

To Explore Genes Related to the Prognosis of Colorectal Cancer

Chen¹,

Tan²,

Yin³

et al. 2023

IJPS

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“…The adaptation limit of lesion size in CSP is because of its en-block resection ability [ 3 , 4 ] and the low frequency of carcinomas. Although the proportion of colorectal cancer in colorectal neoplastic lesions measuring less than 10 mm is thought to be very low, there are lesions with an advanced histology regardless of their small size [ 5 ]. Dye-assisted magnifying colonoscopy and image enhancement have high diagnostic accuracy for not only differentiating neoplastic and non-neoplastic lesions but also for the prediction of invasion depth in submucosal cancers [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cold snare polypectomy (CSP) is a well-established method for the resection of colorectal polyps measuring less than 10 mm, as it is associated with a low frequency of post-procedural bleeding and perforation [ 3 , 4 ]. Although the proportion of malignancy in colorectal neoplastic lesions measuring less than 10 mm is considered very low, small lesions with advanced histology have been reported [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Case of Colorectal Cancer After Cold Snare Polypectomy Successfully Salvaged on Endoscopic Submucosal Dissection

Katagiri

Inoki

Konda

et al. 2020

Cureus

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Cold snare polypectomy is a well-established method for the resection of colorectal polyps measuring less than 10 mm in size. It may be performed in patients with early colorectal cancers because of the difficulty of endoscopic diagnosis. However, the therapeutic effect of cold snare polypectomy on cancers is unknown, and the need for appropriate surveillance and additional treatment for these patients remains to be fulfilled. Endoscopic submucosal dissection has been reported as a safe and effective method for treating recurrent or residual colorectal neoplasia following hot endoscopic mucosal resection. This report is of a case of a colorectal tumor measuring 8 mm that was treated using cold snare polypectomy and resulted in residual cancer. Endoscopic submucosal dissection was selected as salvage treatment for the residual lesion, and histopathological examination revealed free horizontal and vertical margins. We believe that performing endoscopic submucosal dissection at the site of the cancer resected with cold snare polypectomy ensured that there was no residual cancer left. It may be hypothesized that endoscopic submucosal dissection could evolve as the treatment of choice for patients with colorectal cancer after cold snare polypectomy.

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“…However, the positive predictive value of some of these risk factors, such as depth of invasion, is suboptimal and can lead to a high proportion of unnecessary surgeries. The result is that LNM are found in only 10-20% of cases that undergo additional surgical resection after an initial local T1 CRC resection [5][6][7][8]. This means that 80-90% of these patients are exposed to the risks and sequelae of major surgery without any benefit other than confirming the otherwise unlikely absence of regional nodal tumor spread.…”

Section: Introductionmentioning

confidence: 99%

Refining Risk Criteria May Substantially Reduce Unnecessary Additional Surgeries after Local Resection of T1 Colorectal Cancer

Martínez de Juan,

Navarro,

Machado

2024

Cancers

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Background: The low positive predictive value for lymph node metastases (LNM) of common practice risk criteria (CPRC) in T1 colorectal carcinoma (CRC) leads to manyunnecessary additional surgeries following local resection. This study aimed to identify criteria that may improve on the CPRC. Methods: Logistic regression analysis was performed to determine the association of diverse variables with LNM or ‘poor outcome’ (LNM and/or distant metastases and/or recurrence) in a single center T1 CRC cohort. The diagnostic capacity of the set of variables obtained was compared with that of the CPRC. Results: The study comprised 161 cases. Poorly differentiated clusters (PDC) and tumor budding grade > 1 (TB > 1) were the only independent variables associated with LNM. The area under the curve (AUC) for these criteria was 0.808 (CI 95% 0.717–0.880) compared to 0.582 (CI 95% 0.479–0.680) for CPRC. TB > 1 and lymphovascular invasion (LVI) were independently associated with ‘poor outcome’, with an AUC of 0.801 (CI 95% 0.731–0.859), while the AUC for CPRC was 0.691 (CI 95% 0.603–0.752). TB > 1, combined either with PDC or LVI, would reduce false positives between 41.5% and 45% without significantly increasing false negatives. Conclusions: Indicating additional surgery in T1 CRC only when either TB > 1, PDC, or LVI are present could reduce unnecessary surgeries significantly

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Characteristics of minute T1 colorectal cancer in relevance to pathology and treatment

Cited by 4 publications

References 21 publications

To Explore Genes Related to the Prognosis of Colorectal Cancer

To Explore Genes Related to the Prognosis of Colorectal Cancer

Case of Colorectal Cancer After Cold Snare Polypectomy Successfully Salvaged on Endoscopic Submucosal Dissection

Refining Risk Criteria May Substantially Reduce Unnecessary Additional Surgeries after Local Resection of T1 Colorectal Cancer

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